Results 101 to 110 of about 3,574 (243)
Advanced Science, EarlyView.RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li +5 more
wiley +1 more source
A SUCLA2 mutációk szerepe a mitokondrium foszforilációs rendszerének betegségeiben = The Role of SUCLA2 Mutations in the Disorders of the Mitochondrial Phosphorylation System [PDF]
, 2011 Ami a SUCLA2 knock-out egerek használatát illeti, az állatok létrehozása még mindig folyamatban van, annak ellenére, hogy a kifizetés teljes egészében megtörtént. Amint megérkeznek az állatok, munkacsoportunk elsődleges feladata a tervben szereplő, eddig
Chinopoulos, Christos +3 more
core
RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis
Advanced Science, EarlyView.Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao +28 more
wiley +1 more source
Anais da Academia Brasileira de CiênciasBioluminescence - visible and cold light emission by living organisms - is a worldwide phenomenon, reported in terrestrial and marine environments since ancient times.
ETELVINO J.H. BECHARA +1 more
doaj +1 more source
Genetically Modified Coelenterazine-Dependent Luciferases as Reporters for In Vitro Assay [PDF]
Журнал Сибирского федерального университета: Серия Биология, 2017 Among the most important tasks of modern biotechnology is the development of new analytical techniques suitable for highly sensitive and specific detection of diagnostically important targets rapidly expanding their range with the progress in biomedical ...
Ludmila A. Frank +3 more
doaj
Human Bocavirus NS1 and NS1-70 Proteins Inhibit TNF-α-Mediated Activation of NF-κB by targeting p65. [PDF]
, 2016 Human bocavirus (HBoV), a parvovirus, is a single-stranded DNA etiologic agent causing lower respiratory tract infections in young children worldwide.
A Christensen +40 more
core +1 more source
LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1
Advanced Science, EarlyView.LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li +12 more
wiley +1 more source
PLoS ONE, 2009 Networks of protein-protein interactions play key roles in numerous important biological processes in living subjects. An effective methodology to assess protein-protein interactions in living cells of interest is protein-fragment complement assay (PCA).
Naoki Hida +9 more
doaj +1 more source
Construction of a self-luminescent cyanobacterial bioreporter that detects a broad range of bioavailable heavy metals in aquatic environments [PDF]
, 2015 Frontiers in Microbiology 6 (2015): 186 This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permissionA self-luminescent bioreporter strain of the unicellular cyanobacterium ...
Francisca Fernández-Piñas +4 more
core +4 more sources
Advanced Science, EarlyView.Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen +16 more
wiley +1 more source