Results 81 to 90 of about 3,574 (243)

Mapping the structural dynamics of red- and blue-emitting beetle luciferases revealed by HDX-MS

Life Science Alliance
Using HDX-MS, this study demonstrates that conformational flexibility in beetle luciferases governs bioluminescence color, revealing how active site dynamics and domain-specific mutations fine-tune red- and blue-shifted light emission. Beetle luciferases
Abdul-Rahman Kharbatli, Juliana C Ferreira, Nathan M Lui, Rawdah Karwt, Shaolong Zhu, Liaqat Ali, Wael M Rabeh   +6 more
doaj   +1 more source

An Engineered Living Material With Pro‐Angiogenic Activity Inducible by Near‐Infrared Light

Advanced Functional Materials, EarlyView.
NIR‐responsive engineered living materials (ELMs) for controlled angiogenesis: Near‐infrared (800 nm) light activates engineered probiotic bacteria within alginate‐based living materials to secrete a blood vessel‐regenerating protein. The released protein promotes pro‐angiogenic effects in endothelial networks and chick chorioallantoic membranes.
Anwesha Chatterjee, Stefanie S. M. Meier, Sara Trujillo, Andreas Möglich, Shrikrishnan Sankaran   +4 more
wiley   +1 more source

Deciphering the Role of Cancer Stem Cells in Breast Cancer Brain Colonization Using a Novel Patient‐Derived Model

Advanced Healthcare Materials, EarlyView.
This study shows that stem‐like cells isolated from breast cancer brain metastases drive the spread and growth of tumors in the brain. Among them, a highly adhesive subgroup initiates metastasis and resists many drugs. By closely reflecting patient tumors, these models help identify new targets and improve the development of effective treatments ...
Stefania Faletti, Cristina Richichi, Daniela Osti, Elena Ceccacci, Giovanni Bertalot, Camilla Cerutti, Giuseppina Giardina, Adriana Marinaro, Brunella Costanza, Valentina Gambino, Elena Zaccheroni, Daniela Tosoni, Maria G. Filippone, Marcello Del Corvo, Yinxiu Zhan, Teresa Gravina, Davide Corà, Monica Patanè, Bianca Pollo, Maria Giovanna Jodice, Salvatore Pece, Babette B. Weksler, Ignacio A. Romero, Pierre‐Olivier Couraud, Elisabetta Munzone, Massimiliano Del Bene, Francesco DiMeco, Giuliana Pelicci   +27 more
wiley   +1 more source

CORE: Cholesterol Altered Lipid Nanoparticles for Splenic Expression of mRNA Payloads

Advanced Healthcare Materials, EarlyView.
In this paper researchers introduce CORE LNPs, a new class of lipid nanoparticles engineered to redirect mRNA expression away from the liver and into the spleen, a key immune organ. By combining chemical design with computational tools, they created cholesterol analogs that enable precise spleen‐targeted expression, providing greater applications for ...
Eshan A. Narasipura, Vincent Fung, Rachel VanKeulen‐Miller, Palas B. Tiwade, Owen S. Fenton   +4 more
wiley   +1 more source

Coelenterazine Analogs for Bioassays and Molecular Imaging

Sensors
Coelenterazine (CTZ) is a common substrate of marine luciferases upon emission of bioluminescence (BL) in living organisms. Because CTZ works as a “luminophore” in the process of BL emission, the chemical modification has been centered for improving the ...
Sung-Bae Kim, Genta Kamiya, Tadaomi Furuta, Shojiro A. Maki   +3 more
doaj   +1 more source

Cold Atmospheric Plasma‐Activated Decellularized Extracellular Matrix Gel as a Tumor‐Infiltrating Immunoactivation Platform for Post‐Surgical Cancer Immunotherapy

Advanced Materials, EarlyView.
An injectable cold atmospheric plasma‐activated decellularized tumor extracellular matrix hydrogel is introduced as a post‐surgical immunoactivation platform. The engineered gel attracts residual tumor cells and induces immunogenic cell death, reshaping the tumor microenvironment and eliciting systemic antitumor immunity. In combination with checkpoint
Tianxu Fang, Mo Chen, Yueyang Deng, Tianqin Ning, Tianwen Luo, Guojun Chen   +5 more
wiley   +1 more source

The candidate antimalarial drug MMV665909 causes oxygen-dependent mRNA mistranslation and synergises with quinoline-derived antimalarials [PDF]

, 2017
To cope with growing resistance to current antimalarials, new drugs with novel modes of action are urgently needed. Molecules targeting protein synthesis appear to be promising candidates.
Ahyong, Alhebshi, Alonso, Ausubel, Avery, Baragana, Barthelme, Becker, Becker, Beznoskova, Bilsland, Carter, Cervantes, Choi, Cindy Vallières, Cokol, Dever, Duina, Eurwilaichitr, Fan-Minogue, Farabaugh, Flannery, Foucquier, Ghorbal, Gietz, Goodman, Hain, Holland, Holland, Hsieh, Imlay, Islahudin, Islahudin, Jackson, Jenkins, Keeling, Kessl, Kessl, Khoshnevis, Khozoie, Kraft, Laleve, Lehane, Li, Loenarz, Moore, Moreno-Martinez, Nurenberg, Petersen, Pulcini, Py, Radfar, Salas-Marco, Simon V. Avery, Slavic, Song, Sorensen, Spangenberg, Tafazoli, Tarlov, Vaidya, Vallieres, Van Voorhis, WHO, Wu, Zhang   +65 more
core   +3 more sources

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source

Investigation of the in vitro inhibitory mechanisms of quercetin on varicella-zoster virus [PDF]

, 2015
摘要 【目的】 1、应用水痘-带状疱疹病毒（VZV）报告细胞系MV9G细胞从植物药成分中筛选具有抑制VZV作用的物质。 2、应用VZV报告细胞系MV9G研究槲皮素体外抑制VZV作用及其机制。 【方法】 1、植物药成分的细胞毒性试验：MV9G细胞分别在含有丁子香酚、桑色素、姜黄素、杨梅酮和槲皮素的培养基中培养72hrs后测定MV9G细胞的ATP含量，根据药物对MV9G细胞ATP含量的影响分析药物的细胞毒性，并计算植物药成分对MV9G细胞的半数致死浓度（CD50）。 2、植物药成分对VZV半数抑制浓度测定 ...
廉成翔
core  

Autonomous Cargo Transport with Biohybrid Microswimmers Enabled by Light‐Mediated Bacteria‐Cargo Communication

Advanced Materials, EarlyView.
ABSTRACT Biohybrid microswimmers, which integrate the unique mobility and taxis of living cells with the versatility of synthetic cargo, offer exciting opportunities for targeted delivery. However, current biohybrids lack autonomous decision‐making capabilities due to the absence of communication between living and synthetic components. Here, we report
Xiaoran Zheng, Yanjun Zheng, Ali Heidari, Seraphine V. Wegner   +3 more
wiley   +1 more source