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Advanced Science, Volume 13, Issue 13, 3 March 2026.This study investigates the role of M2 macrophage‐derived extracellular vesicles (M2 EVs) in prostate cancer (PCa) metastasis. Mechanistically, M2 EVs horizontally transfer TXNDC5 mRNA to PCa cells, where the molecule induces the mesenchymal‐like state (MLS), enhancing PCa migration and invasion.
Cong Hu +14 more
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Luciferins, Bioluminescent Substances
Angewandte Chemie International Edition in English, 1968AbstractThe bioluminescence of the American firefly Photinus is due to the reaction of 2‐(6‐hydroxybenzothiazol‐2‐yl)‐Δ2‐1,3‐thiazoline‐4‐carboxylic acid (“firefly luciferin”) with the enzyme luciferase in the presence of ATP and magnesium ion. In the crustacean Cypridina, on the other hand, the bioluminescence is due to the reaction of a luciferase ...
T, Goto, Y, Kishi
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An Interphylum Luciferin-Luciferase Reaction
Science, 1960The light-emitting enzyme-substance systems, heretofore separated from different types of luminescent organisms, exhibit a marked biological specificity and comprise chemically different components. Extracts from a luminescent fish are now found to cross react with a crustacean system; some properties of the new system and implications of the ...
F H, Johnson, Y, Haneda, E H, Sie
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Isolation studies with Cypridina luciferin
Archives of Biochemistry and Biophysics, 1961Abstract An attempt to isolate Cypridina luciferin in pure form has been made. The most promising approaches have involved the use of countercurrent distribution and membrane diffusion. Although the final objective was not realized because of instability and lack of material, the experiments strongly indicated the active chromophore to be a low ...
P, MARFEY, L C, CRAIG, E N, HARVEY
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Bacterial and Other "Luciferins"
BioScience, 1975Although luminous bacteria were among the very first of bioluminescent organisms to be made the subject of scientific research (Boyle 1667a,b), only recently has a satisfactory answer to one of the most puzzling aspects of bacterial luminescence become firmly established (McCapra and Hysert 1973, Dunn et al. 1973, Shimomura et al. 1972, 1974, Vigny and
Frank H. Johnson, Osamu Shimomura
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Novel Heterocyclic Analogues of Firefly Luciferin
Biochemistry, 2012Five novel firefly luciferin analogues in which the benzothiazole ring system of the natural substrate was replaced with benzimidazole, benzofuran, benzothiophene, benzoxazole, and indole were synthesized. The fluorescence, bioluminescence, and kinetic properties of the compounds were evaluated with recombinant Photinus pyralis wild type luciferase ...
Carolyn C, Woodroofe +7 more
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Chemiluminescence of Firefly Luciferin without Enzyme
Science, 1962We have been able to produce chemiluminescence in firefly luciferin without utilizing the enzyme luciferase. Following the analogous mechanism of the chemiluminescence of luminol in the organic solvent dimethyl sulfoxide, we have prepared synthetically the methyl ester of luciferin, the phosphate ester of luciferin and luciferyl adenylate ...
H H, SELIGER, W D, McELROY
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Multicolor Bioluminescence Obtained Using Firefly Luciferin
Current Topics in Medicinal Chemistry, 2016Firefly bioluminescence is widely used in life science research as a useful analysis tool. For example, the adenosine-5`-triphosphate (ATP)-dependent enzymatic firefly bioluminescence reaction has long been utilized as a microbial monitoring tool. Rapid and sensitive firefly luciferin-luciferase combinations are used not only to measure cell viability ...
Masahiro, Kiyama +5 more
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