Results 191 to 200 of about 504,468 (237)

A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain Via Notochordal Cell Loss and Pain‐Inducing Nucleus Pulposus Cell Emergence

JOR SPINE, Volume 9, Issue 3, September 2026.
A porcine model of disc injury recapitulates key clinical, histological, and molecular features of human discogenic low back pain. Multi‐omics analyses identify a shift from notochordal cells to pain‐associated nucleus pulposus cells as a potential driver of disease progression. ABSTRACT Background Lower back pain (LBP) is one of the most common causes
Giselle Kaneda, Jacob T. Wechsler, Melissa Chavez, Julia Sheyn, Karandeep Cheema, Chushu Shen, Dante Rigo De Righi, Lixia Wang, Yin‐Chen Hsu, Pablo Avalos, Yibin Xie, Wafa Tawackoli, Candace Floyd, Debiao Li, Dmitriy Sheyn   +14 more
wiley   +1 more source

Quercetin relieves compression-induced cell death and lumbar disc degeneration by stabilizing HIF1A protein. [PDF]

Heliyon
Ren J, Xin R, Cui X, Xu Y, Li C.
europepmc   +1 more source

Semi‐Automated μCT‐Based Modeling of Vertebral Bony Endplate Microporosity and Mechanical Properties: Linking Microstructure to Inferred Mechanical Performance

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT Background The vertebral bony endplate (BEP) plays a role in regulating both mechanical load transfer and nutrient transport to the intervertebral disc, functions strongly influenced by its microstructural porosity. Variations in porosity impact bone strength, elasticity, and solute diffusion, affecting its overall mechanical competence ...
Ahmad Alminnawi, Gabriele Nasello, Katherine B. Crump, Benjamin Gantenbein, Jerome Noailly, Liesbet Geris   +5 more
wiley   +1 more source

The association of limited or painful spinal range of motion with lumbar disc degeneration: the back complaints in older adults (BACE) study. [PDF]

BMC Musculoskelet Disord
Feller D, van den Berg R, Enthoven WTM, Oei EHG, Bierma-Zeinstra SM, Koes BW, Chiarotto A.   +6 more
europepmc   +1 more source

Transgenic Conversion of Omega‐6 to Omega‐3 Fatty Acids via fat‐1 Reduces Obesity‐Related Intervertebral Disc Degeneration

JOR SPINE, Volume 9, Issue 3, September 2026.
We investigated whether transgenic conversion of omega‐6 to omega‐3 fatty acids mitigates obesity‐associated intervertebral disc (IVD) degeneration. Using fat‐1 mice on a high‐fat diet, we observed that endogenous omega‐3 production prevented diet‐induced disc pathology, metabolic dysfunction, and reduced systemic inflammation, indicating a protective ...
Shirley N. Tang, Kristin L. Lenz, Emma Shen, Collin Murray, Nikitha Ada, Sarada Prasad, Mohammed Kuziez, Farshid Guilak, Arin K. Oestreich   +8 more
wiley   +1 more source

Association between severe lumbar disc degeneration and end-stage hip or knee osteoarthritis requiring joint replacement surgery: a population-based cohort study with a 26-year follow-up. [PDF]

Arch Orthop Trauma Surg
Salo S, Sund R, Rikkonen T, Huopio J, Hurri H, Kröger H, Sirola J.   +6 more
europepmc   +1 more source

Surviving the Nucleus Pulposus Desert: Next‐Generation Strategies for Intervertebral Disc Cell Therapy

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACTBackgroundLow back pain remains the leading cause of disability worldwide, with intervertebral disc degeneration representing a major biological contributor. Although cell‐based therapies have shown promise in preclinical models, clinical translation has yielded modest and inconsistent outcomes.
Tynhinane Hamidouche, Namdev More, Tiffany Lee, Mia Orr, Anne Camus, Devina Purmessur, Sarah E. Gulbrand, Nadeen O. Chahine, Lara Silverman, Dmitriy Sheyn   +9 more
wiley   +1 more source

Evaluating lumbar disc degeneration by MRI quantitative metabolic indicators: the perspective of factor analysis. [PDF]

J Orthop Surg Res
Zheng B, Ouyang L, Shi J, Shen X, Lei H.
europepmc   +1 more source

Spatial Investigation of Facet Joint Cartilage Properties Reveals Specific Structure–Function Relationships

JOR SPINE, Volume 9, Issue 3, September 2026.
The inferior facet of the L2 vertebra and the superior facet of the L3 vertebra were harvested from ovine lumbar spines. The spatial biomechanical properties of the facet cartilage surfaces were determined by indentation mapping. Cartilage structure was spatially analyzed on a macroscopic and microscopic level.
Luisa de Roy, Ann‐Kathrin Greiner‐Perth, Graciosa Quelhas Teixeira, Benjamin Mayer, Hans‐Joachim Wilke, Andreas Martin Seitz, Christian Liebsch   +6 more
wiley   +1 more source

Human In Vivo Disc Mechanics in Flexion, Extension, and Diurnal Loading With Aging and Degeneration

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT Background The intervertebral disc serves a critical role in spine function, but with aging and degeneration the disc undergoes changes that alter disc mechanics, and degeneration is often implicated in low back pain. The objective of this study was to quantify and evaluate the impact of aging and degeneration on in vivo lumbar disc mechanics ...
Harrah R. Newman, John M. Peloquin, Edward J. Vresilovic, Dawn M. Elliott   +3 more
wiley   +1 more source