Results 181 to 190 of about 504,468 (237)

Correlation analysis of lumbar disc degeneration characteristics and bone mineral density in patients with osteoporosis based on the Roussouly classification. [PDF]

Quant Imaging Med Surg
Zhao S, Chen M, Chen S, Huang Y, Ma W, Yan Z, He J.   +6 more
europepmc   +1 more source

Proteomic Atlas of Notochordal Cell‐Derived Extracellular Vesicles Highlights EV‐Specific NF‐κB Modulation and Functional Implications of the Protein Corona

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT The notochord is a central signalling hub during embryonic development. After regression of the notochord, notochordal cells (NCs) reside within the developing intervertebral disc. The NC‐secretome, including matrix, proteins and extracellular vesicles (NC‐EVs), promotes regeneration of degenerate intervertebral discs and cartilage. This study
Josette C. van Maanen, Chantal Voskamp, Frank M. Riemers, Harmjan R. Vos, Anouk Eversdijk, Marije Kleinjan, Menno Bergmeijer, Martijn J. C. van Herwijnen, Stuart C. Howes, Frances C. Bach, Tim J. M. Welting, Christine L. Le Maitre, Guus G. H. van den Akker, Marca H. M. Wauben, Mariana A. Tryfonidou   +14 more
wiley   +1 more source

Miliary Tuberculosis Diagnosed After Repeated Sputum Smear Examinations Despite Negative Results at a Referral Tuberculosis Center: The Importance of Maintaining Clinical Suspicion

Journal of General and Family Medicine, Volume 27, Issue 5, September 2026.
ABSTRACT An 88‐year‐old woman with back pain was found to have destructive changes at T9/T10 and diffuse micronodular pulmonary opacities suggestive of miliary tuberculosis. At two referring hospitals, six sputum smears and two interferon‐gamma release assays were negative.
Kento Kabeya, Kousuke Mouri, Hidehiro Someko   +2 more
wiley   +1 more source

Lumbar Disc Degeneration and Vertebral Fracture at the Thoracolumbar Junction Are Risk Factors for Chronic Low Back Pain With Disability: Seven Years' Follow-Up of the Wakayama Spine Study. [PDF]

Cureus
Iwane N, Hashizume H, Murata S, Mure K, Oka H, Iidaka T, Teraguchi M, Nagata K, Ishimoto Y, Takami M, Tsutsui S, Iwasaki H, Tanaka S, Yamada H, Yoshimura N.   +14 more
europepmc   +1 more source

Lysosomal Dysfunction Is Associated With Intervertebral Disc Degeneration: Multiomics and Machine Learning Identify Molecular Subtypes and Hub Genes

The Journal of Gene Medicine, Volume 28, Issue 9, September 2026.
Intervertebral disc degeneration (IVDD) is linked to lysosomal dysfunction, impaired autophagic degradation, and cellular senescence. Integrating bulk and single‐cell transcriptomics with machine learning, this study identified two lysosome‐related molecular subtypes and four hub genes: HYAL1, MMD, PLD3, and ANK3.
Yang Yang, Hong Li, Yixuan Ou, Yaping Yu, Kaiqiang Sun, Shixing Chen, Chenglong Ji   +6 more
wiley   +1 more source

Lost in Translation: Why Biologic Therapies for Intervertebral Disc Degeneration and Low Back Pain Have Not Reached the Clinic (Yet)

JOR SPINE, Volume 9, Issue 3, September 2026.
From preclinical promise to clinical translation in intervertebral disc degeneration (IDD). Robust preclinical evidence supports a range of biologic therapies, with consistent improvements in imaging, extracellular matrix composition, inflammation, and behavior.
Luca Ambrosio, Jordy Schol, Clara Ruiz‐Fernandez, Vincenzo Denaro, Gianluca Vadalà, Daisuke Sakai   +5 more
wiley   +1 more source

Bone morphogenetic proteins, DNA methylation, and gut microbiota interaction in lumbar disc degeneration: A multi-omics Mendelian randomization study. [PDF]

JOR Spine
Li XY, Wang PY, Wang QJ, Wang DF, Wang SK, Wang Y, Zhu WG, Wang W, Kong C, Lu SB, Chen XL.   +10 more
europepmc   +1 more source

Galectin‐4: A Novel Mediator of Human Intervertebral Disc Degeneration

JOR SPINE, Volume 9, Issue 3, September 2026.
Galectin‐4 correlates with intervertebral disc degeneration, independent of age, sex, or underlying pathology. Functionally, it activates NF‐κB signaling and induces pro‐inflammatory and matrix‐degrading responses, with stronger effects in nucleus pulposus cells, identifying it as a novel molecular player in disc degeneration.
Christine Strauss, Daniel Djojic, Johannes Stadlmann, Josef Georg Grohs, Jürgen Alphonsus, Sebastian Schmidt, Sabine André, Katharina Margareta Pichler, Sara Savic‐Ivanovic, Melanie Cezanne, Mario Rothbauer, Reinhard Windhager, Stefan Toegel   +12 more
wiley   +1 more source

Effective disc age: a statistical model for age-dependent and level-specific lumbar disc degeneration using magnetic resonance imaging (MRI). [PDF]

Eur Spine J
Newman HR, Peloquin JM, Meadows KD, Bodt BA, Vresilovic EJ, Elliott DM.   +5 more
europepmc   +1 more source

Abstracts from the 2026 Congress of the Scandinavian Society of Anesthesiology and Intensive Care Medicine, Reykjavik, Iceland, June 10–12, 2026

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 9, October 2026.
wiley   +1 more source