Results 161 to 170 of about 504,468 (237)

Maternal‐Fetal Administration of Risdiplam Partially Rescues the SMNΔ7 Mouse Model of Spinal Muscular Atrophy

Annals of Neurology, Volume 100, Issue 3, Page 584-599, September 2026.
Objective Spinal muscular atrophy (SMA) is caused by deletions or mutations in the survival motor neuron 1 (SMN1) gene and subsequent reduction in the expression of survival motor neuron (SMN) protein. The disease is characterized by degeneration of α motor neurons and subsequent muscle atrophy.
Emma R. Sutton, Ariane Beauvais, Rebecca Yaworski, Hugh J. McMillan, Rashmi Kothary   +4 more
wiley   +1 more source

Age and Spinal Level as Predictors of Lumbar Disc Degeneration in Humans and Mice: A Comparative Analysis. [PDF]

JOR Spine
Mehta R, Mohanty S, Hallmark AP, Shah V, Ross T, Bogner EA, Pannu TS, Bannwarth M, Virk S, Iyer S, Farmer JC, Huang RC, Lebl DR, Rawlins BA, Sandhu HS, Kim HJ, Cunningham ME, Qureshi S, Albert TJ, Dahia CL.   +19 more
europepmc   +1 more source

Comorbidity Mechanism and Management of Chronic Low Back Pain and Major Depressive Disorder: From Neural Circuit Remodeling to Precision Medicine

Brain and Behavior, Volume 16, Issue 9, September 2026.
ABSTRACT Objective This review systematically elaborates multi‐system interactive mechanisms underlying comorbid chronic low back pain (CLBP) and major depressive disorder (MDD), synthesizes recent advances in diagnosis, treatment, and management, and proposes precision medicine directions to address clinical challenges, including missed diagnosis ...
Lin Faqu, Lin Chenjuan, Xiang Xiangyin, Li Xin   +3 more
wiley   +1 more source

Downregulation and Hypermethylation of Vitamin D Receptor in Lumbar Disc Degeneration. [PDF]

Int J Mol Sci
Vajarintarangoon L, Limthongkul W, Singhatanadgige W, Kotheeranurak V, Yingsakmongkol W, Thongtan T, Dechsupa S, Honsawek S.   +7 more
europepmc   +1 more source

CSF Tau and Amyloid Biomarkers in Cognitive Impairment Across the ALS–FTD Spectrum: A Systematic Narrative Review and Evidence Map

Brain and Behavior, Volume 16, Issue 9, September 2026.
ABSTRACT Introduction Cognitive impairment is an important non‐motor manifestation of amyotrophic lateral sclerosis (ALS), particularly across the ALS–frontotemporal dementia (ALS–FTD) spectrum. Cerebrospinal fluid (CSF) tau and amyloid biomarkers may reflect nonspecific neurodegenerative injury, concomitant Alzheimer disease (AD) pathology, or ...
Aasim Ali, Muhammad Arif, Usama Ashraf, Saad Elahi, Aswad Mustafa, Mahad Bin Yasir, Waqar Sarfraz, Asad Ullah Ansari, Hafiz Muhammad Yousaf Masood, Muhammad Asad Shabbir, Armaghana Abdullah, Mukesh Kumar Sharma   +11 more
wiley   +1 more source

Establishment of rabbit models of lumbar disc degeneration using three methods monitored via X-ray: a comparative study. [PDF]

J Orthop Surg Res
Shi X, Li Y, Lou J, An H, Wu T, Zheng Y, Wang W, Zhang T, Liu H.   +8 more
europepmc   +1 more source

Dermatome‐Specific Herpes Zoster Following Corticosteroid Therapy for Lumbar Disc Herniation: A Case Report Illustrating the Immunocompromised District Theory

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Systemic corticosteroids frequently utilized to manage lumbosacral radiculopathy introduce an immunological paradox by potentially triggering varicella‐zoster virus reactivation. While well‐documented in severely immunocompromised populations, the specific neuro‐immunological mechanisms in otherwise immunocompetent patients with lumbar disc ...
Jun Liu, Lili Luo, Ming Zhou, Weifeng Chen, Na Cao, Zhanglin Pu, Yunwei Niu, Jiachen Guo, Huayuan Liao, Yi Li, Jun Gao, Kang Wei   +11 more
wiley   +1 more source

Integration of single-cell sequencing and machine learning identifies key macrophage-associated genetic signatures in lumbar disc degeneration. [PDF]

Front Immunol
Zhang H, Dai B, Peng J, Gao M, Li D, Xiang X, Zhu J.   +6 more
europepmc   +1 more source

Unusual Spinal Epidural and Paraspinal Venous Engorgement Secondary to Hepatosplenic Schistosomiasis: A Rare Cause of Severe Low Back Pain

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Severe low back pain from spinal epidural and paraspinal venous engorgement secondary to hepatosplenic schistosomiasis is rare. MRI revealed dilated epidural veins and neural foraminal narrowing. The patient was managed conservatively with analgesia and carvedilol for portal hypertension and subsequently experienced complete resolution of back
Endalew Dessie Birara, Yonas Damtew Bejiga, Rediet Girmaye, Elias Getahun Bayu, Hosea Manyazewal Anberber, Alefe Aklewok Tadesse, Habtamu Ferede Kidanu, Ragasa Getachew Bayisa, Tamirat Godebo Woyimo   +8 more
wiley   +1 more source

Correction to "The Research of Transgenic Human Nucleus Pulposus Cell Transplantation in the Treatment of Lumbar Disc Degeneration". [PDF]

Kaohsiung J Med Sci
europepmc   +1 more source