Results 151 to 160 of about 504,468 (237)

THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome

Advanced Science, Volume 13, Issue 53, 24 September 2026.
The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong, Qize Xue, Xiaoan Wei, Jie Li, Bao Huang, Weishao Chen, Zimin Cai, Tao Yang, Chengjun Yao, Jiayan Jin, Bohan Cai, Xuyang Zhang, Junhui Liu, Haihao Wu, Jian Chen, Zhi Shan, Fengdong Zhao   +16 more
wiley   +1 more source

The impact of overall lumbar disc degeneration burden on disability outcomes following surgery for lumbar spinal stenosis due to osteoarthritis. [PDF]

Osteoarthr Cartil Open
Rampersaud YR, Power JD, Nahanni C, Fine N, Canizares M, Kapoor M, Perruccio AV.   +6 more
europepmc   +1 more source

Persistent expression of NLRP3 in spinal microglia promotes development of lumbar disc degeneration. [PDF]

Front Immunol, 2022
Wang P, Zhang J.
europepmc   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, Volume 13, Issue 54, 28 September 2026.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Clinical-transcriptomic classification of lumbar disc degeneration enhanced by machine learning. [PDF]

Mil Med Res
Jin HJ, Lin P, Ma XY, Huang S, Zhang L, Hu O, Li YY, Wang YB, Zhu J, Hu B, Pu JG, Qin Q, Yan PL, Liu B, Lan Y, Chen L, Xie YL, He J, Gan YB, Liu P.   +19 more
europepmc   +1 more source

Second‐to‐Fourth Digit (2D:4D) Ratio as A Risk Factor for Osteoporosis and Osteoarthritis: A Systematic Review

American Journal of Human Biology, Volume 38, Issue 9, September 2026.
ABSTRACT Background The second‐to‐fourth digit (2D:4D) ratio is an established marker of prenatal sex hormone exposure and has been associated with various health outcomes across the lifespan. Increasing evidence suggests that developmental factors reflected by the 2D:4D ratio may contribute to susceptibility to musculoskeletal disorders, including ...
Özlem Elvan, Birgül Vural Doğru, Emine Kaplan Serin   +2 more
wiley   +1 more source

Hospitalizations and surgical management of lumbar disc degeneration in Italy: a 22-Year nationwide retrospective study. [PDF]

BMC Musculoskelet Disord
Russo F, Rondinone BM, Papalia GF, Vadalà G, Papalia R, Denaro V, Iavicoli S.   +6 more
europepmc   +1 more source

Retracted: Quantitative Relationship between the Degree of Lumbar Disc Degeneration and Intervertebral Disc Height in Patients with Low Back Pain. [PDF]

Contrast Media Mol Imaging, 2023
Imaging CMM.
europepmc   +1 more source

Genetic and molecular evidence linking CTSH to Alzheimer's disease pathophysiology

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Lysosomal dysfunction contributes to Alzheimer's disease (AD) by impairing protein clearance and promoting neuroinflammation. Cathepsin H (CTSH), a lysosomal protease, recently emerged as a protective AD locus. We investigated how CTSH is regulated and how it influences early AD pathophysiology.
Cynthia Picard, Gabriel Aumont‐Rodrigue, Isabel Sarty, Julia Loncke, Mélissa Savard, Laurence Maligne‐Bruneau, Judes Poirier, for the PREVENT‐AD research group   +7 more
wiley   +1 more source

The role of co-occurring obesity in the association between lumbar disc degeneration and disability related to low back pain. [PDF]

BMC Musculoskelet Disord
Mertimo T, Oura P, Karppinen J, Niinimäki J, Sequeiros RB, Määttä J, Kankaanpää M, Heikkala E.   +7 more
europepmc   +1 more source