Results 141 to 150 of about 504,468 (237)

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, Volume 13, Issue 9, Page 1842-1850, September 2026.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

The clinical role of lncRNA PRKG1-AS1 in lumbar disc degeneration and its mechanism in regulating inflammation and ferroptosis via miR-218-5p. [PDF]

J Orthop Surg Res
Xu J, Ma Z, Wang L, Lu Z, Wang T, Liu J, Zhao Y, Zhu X, Xi B.   +8 more
europepmc   +1 more source

Analysis of trunk rotation during baseball batting with lumbar disc degeneration. [PDF]

Fukushima J Med Sci, 2023
Taguchi N, Izumi S, Miyakawa S.
europepmc   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, Volume 13, Issue 9, Page 1903-1918, September 2026.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Emerging Biologics in Lumbar Disc Degeneration: PRP, Stem Cell Therapy, and Pharmacotherapy in Mobility Restoration and Rehabilitation. [PDF]

J Spine Res Surg
Aabedi A, Agrawal DK.
europepmc   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, Volume 13, Issue 54, 28 September 2026.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Elemental imbalance and oxidative biomarker shifts in lumbar disc degeneration. [PDF]

Front Neurol
Strojny D, Wojdyła R, Skóra K, Hoczela M, Wyczarska-Dziki K, Rajchel M, Miller M, Sobański D, Staszkiewicz R, Wieczorek J, Chwalba A, Rogoziński P, Grabarek BO.   +12 more
europepmc   +1 more source

Telomere Shortening and Increased Oxidative Stress in Lumbar Disc Degeneration. [PDF]

Int J Mol Sci, 2022
Jitjumnong M, Chalermkitpanit P, Suantawee T, Dechsupa S, Vajarintarangoon L, Honsawek S.   +5 more
europepmc   +1 more source

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, Volume 13, Issue 53, 24 September 2026.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source

MRI-Based Grading Systems for Assessing Lumbar Disc Degeneration: A Scoping Review. [PDF]

JOR Spine
Esposito D, Brown B, Hancock MJ, King SSG, Searant IGT, Jenkins H.   +5 more
europepmc   +1 more source