Results 91 to 100 of about 23,756 (251)

CTHRC1 Derived From Cancer‐Associated Fibroblasts Promotes Pancreatic Cancer Progression and Metastasis via the LIF‐STAT3 Pathway

Cancer Medicine, Volume 14, Issue 15, August 2025.
ABSTRACT Background Collagen triple helix repeat containing 1 (CTHRC1) is a secreted protein involved in tissue remodeling and fibrotic processes, which also suggests emerging roles in cancer. Studies have shown that it is mainly expressed in the outer membrane fibroblasts of injured arteries and in the neointimal smooth muscle cells, where it promotes
Hang Yin, Yue Pan, Zhuang Li, Yong Liu, Jiatong Chen, Xin Chen, Chengfei Zhang, Feng Zhu, Chunzhao Yu   +8 more
wiley   +1 more source

δ-Catenin activates Rho GTPase, promotes lymphangiogenesis and growth of tumor metastases. [PDF]

PLoS ONE, 2015
δ-Catenin, an adherens junctions protein, is not only involved in early development, cell-cell adhesion and cell motility in neuronal cells, but it also plays an important role in vascular endothelial cell motility and pathological angiogenesis.
Sampa Ghose, Yongfen Min, P Charles Lin
doaj   +1 more source

Fucoidan From Brown Algae as a Functional Food Ingredient: A Promising Anticancer Agent

eFood, Volume 6, Issue 4, August 2025.
Fucoidan, a bioactive polysaccharide from brown algae, inhibits receptor tyrosine kinase (RTK) activation and vascular endothelial growth factor (VEGF) signaling, suppressing the phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) and RAS/RAF/mitogen‐activated protein kinase/extracellular signal‐regulated kinase ...
Muhammad Umer Khan, Iqra Khurram, Maha Munir, Muhammad Ikram Ullah, Heba Bassiony Ghanem, Javad Sharifi‐Rad, William N. Setzer, Daniela Calina   +7 more
wiley   +1 more source

Atypical E2fs control lymphangiogenesis through transcriptional regulation of Ccbe1 and Flt4. [PDF]

PLoS ONE, 2013
Lymphatic vessels are derived from venous endothelial cells and their formation is governed by the Vascular endothelial growth factor C (VegfC)/Vegf receptor 3 (Vegfr3; Flt4) signaling pathway.
Bart G M W Weijts, Andreas van Impel, Stefan Schulte-Merker, Alain de Bruin   +3 more
doaj   +1 more source

High‐throughput screen identifies MAS9 as a novel inhibitor of the C‐type lectin receptor‐2 (CLEC‐2)–podoplanin interaction

British Journal of Pharmacology, Volume 182, Issue 16, Page 3838-3851, August 2025.
Abstract Background and Purpose The C‐type lectin‐like receptor‐2 (CLEC‐2) is a platelet receptor for the endogenous ligand podoplanin. This interaction contributes to several (patho)physiological processes, such as lymphangiogenesis, preservation of blood and lymphatic vessel integrity organ development, and tumour metastasis.
Marcin A. Sowa, Yan Wu, Jan van Groningen, Ying Di, Helma van den Hurk, Johannes A. Eble, Jonathan M. Gibbins, Ángel García, Alice Y. Pollitt   +8 more
wiley   +1 more source

Adenosine A2a receptor promotes lymphangiogenesis and lymph node metastasis

OncoImmunology, 2019
The formation of new lymphatic vessels, or lymphangiogenesis, is a critical step of the tissue repair program. In pathological conditions involving chronic inflammation or tumorigenesis, this process is often dysregulated and can contribute to disease ...
Bertrand Allard, Isabelle Cousineau, David Allard, Laurence Buisseret, Sandra Pommey, Pavel Chrobak, John Stagg   +6 more
doaj   +1 more source

CCBE1 promotes tumor lymphangiogenesis and is negatively regulated by TGFβ signaling in colorectal cancer

Theranostics, 2020
Collagen and calcium-binding EGF domain-1 (CCBE1) is essential for lymphatic vascular development as it promotes vascular endothelial growth factor C (VEGFC) proteolysis.
Jinglue Song, Wei Chen, Xuewei Cui, Zhenyu Huang, Dongpeng Wen, Yili Yang, Wei Yu, L. Cui, Chen-Ying Liu   +8 more
semanticscholar   +1 more source

Dental pulp lymphatic vessel dynamics during tooth development and pulp stimulation in rodents

International Endodontic Journal, Volume 58, Issue 8, Page 1197-1210, August 2025.
Abstract Aim The anatomy and functions of lymphatic vessels (LV) in mammals remain poorly understood compared to the blood vascular system. In particular, whether or not LV exist in the dental pulp is still controversial. This study aims to identify the existence of LV in the mouse dental pulp using a Prox1 (Prospero homeobox 1)‐eGFP transgenic mouse ...
Kento Tazawa, Di Chen, Akira Fujimura, Philip D. King, Hajime Sasaki   +4 more
wiley   +1 more source

Foxp3 is correlated with VEGF-C expression and lymphangiogenesis in cervical cancer

World Journal of Surgical Oncology, 2017
Background Recent observations revealed Foxp3 participated in the development of cervical cancer. Furthermore, Foxp3 has a vital function in the lymphatic metastasis of cervical cancer.
Jiabu Tang, Zheng Yang, Zhuo Wang, Zhen Li, Hongmei Li, Jinbao Yin, Min Deng, Wei Zhu, Chao Zeng   +8 more
doaj   +1 more source

Sunitinib as Second‐Line Treatment in Advanced Intrahepatic Cholangiocarcinoma: Results From the SUN‐CK GERCOR Phase II Trial

Liver International, Volume 45, Issue 8, August 2025.
ABSTRACT Background & Aims Angiogenesis is critical in intrahepatic cholangiocarcinoma (ICC), a highly lethal cancer with limited treatment options. Sunitinib, a multi‐receptor tyrosine kinase inhibitor, has strong antiangiogenic and antitumor effects.
Louis Gros, Mohamed Bouattour, Clément Dumont, Laëtitia Dahan, David Malka, Annemilaï Tijeras‐Raballand, Armand De Gramont, Maxime Ronot, Chantal Dreyer, Cindy Neuzillet, Philippe Bourget, Alexandra Hadengue, Nelly Roldan, Marie‐Line Garcia‐Larnicol, Benoist Chibaudel, Eric Raymond, Sandrine Faivre   +16 more
wiley   +1 more source