Results 91 to 100 of about 33,222 (220)

Novel Identification of LYVE-1 Positive Macrophages in Rheumatoid Synovial Tissue [PDF]

, 2016
Objective: LYVE-1+ macrophages are observed in a range of cancers, where they play a role in tumour lymphangiogenesis. In rheumatoid arthritis (RA), lymphangiogenesis increases in the early stage of the disease and decreases as it progresses, potentially
Kehoe, O, Mattey, DL, Middleton, J, Rump, LJ   +3 more
core   +1 more source

Exploring Long Noncoding RNAs as Regulators of Tumor Ferroptosis: Advances and Challenges

Cancer Science, EarlyView.
Long noncoding RNAs (lncRNAs) play pivotal roles in regulating gene expression and are closely associated with cancer progression, prognosis, and therapeutic resistance. This review highlights recent advancements in understanding how lncRNAs modulate ferroptosis, a regulated form of cell death characterized by iron‐dependent lipid peroxidation ...
Gang Li, Bing Wang, Lisha Ye, Guohua Wang   +3 more
wiley   +1 more source

Biological Basis of Therapeutic Lymphangiogenesis [PDF]

Circulation, 2011
The lymphatic vascular system is crucial for the regulation of tissue fluid homeostasis, immune function, and fat metabolism. Lymphatic dysfunction, either due to gene mutations or secondary to damage to the lymph vessels, may lead to lymphedema, a debilitating condition characterized by chronic tissue edema, impaired immunity, and accumulation of ...
Tuomas Tammela, Camilla Norrmén, Tatiana V. Petrova, Kari Alitalo   +3 more
openaire   +3 more sources

Lymphangiogenesis: from the pig embryos to cancer [PDF]

, 2008
The discovery and the comprehension of lymphatic vessels suffered several historical delays and setbacks. The inherent anatomical problems slowed down the precise identification of the lymphatic system during the development of medical science.
Duarte, Maria, Longatto Filho, Adhemar, Schmitt, Fernando C.   +2 more
core   +3 more sources

Dental pulp lymphatic vessel dynamics during tooth development and pulp stimulation in rodents

International Endodontic Journal, EarlyView.
Abstract Aim The anatomy and functions of lymphatic vessels (LV) in mammals remain poorly understood compared to the blood vascular system. In particular, whether or not LV exist in the dental pulp is still controversial. This study aims to identify the existence of LV in the mouse dental pulp using a Prox1 (Prospero homeobox 1)‐eGFP transgenic mouse ...
Kento Tazawa, Di Chen, Akira Fujimura, Philip D. King, Hajime Sasaki   +4 more
wiley   +1 more source

The Role of Stromal Tumor Environment in Advancing Skin Cancer Diagnosis and Treatment

International Journal of Dermatology, EarlyView.
ABSTRACT The stromal tumor environment (STE) plays a vital yet often underrecognized role in cancer progression, shaping tumor development. It influences complex interactions among stromal cells, immune cells, extracellular matrix (ECM) components, and signaling molecules.
Frank Jing, Ani Pazhava, Catherine Shachaf, Alexander Meves   +3 more
wiley   +1 more source

A zebrafish model of inflammatory lymphangiogenesis [PDF]

Biology Open, 2015
ABSTRACT Inflammatory bowel disease (IBD) is a disabling chronic inflammatory disease of the gastrointestinal tract. IBD patients have increased intestinal lymphatic vessel density and recent studies have shown that this may contribute to the resolution of IBD.
Okuda, KS, Misa, JP, Oehlers, SH, Hall, CJ, Ellett, F, Alasmari, S, Lieschke, GJ, Crosier, KE, Crosier, PS, Astin, JW   +9 more
openaire   +5 more sources

Defective lymphatic vasculature in obesity

Obesity Reviews, EarlyView.
Summary Lymphedema is an important, and often underdiagnosed complication of obesity and is likely due to acquired defects in the lymphatic vasculature. Study of diet‐induced obesity animal models have indicated defective lymphatic vasculatures might extend to other anatomical sites, especially visceral depots.
Jingjing Zhu, John P. H. Wilding, Ji Hu
wiley   +1 more source

Lipedema: Progress, Challenges, and the Road Ahead

Obesity Reviews, EarlyView.
ABSTRACT Introduction Lipedema is a chronic and progressive disease that predominantly affects women, characterized by a disproportionate increase in subcutaneous adipose tissue (AT), particularly in the lower limbs. It is associated with significant physical disability, chronic pain, thromboembolism, and psychosocial distress.
Vincenza Cifarelli
wiley   +1 more source

Apelin promotes lymphangiogenesis and lymph node metastasis [PDF]

, 2014
International ...
Berger, Walter, Berta, Judit, Döme, Balázs, Garay, Tamás, Groger, Marion, Grusch, Michael, Hegedűs, Balázs, Hoda, Mir Alireza, Klepetko, Walter, Laszlo, Viktória, Masri, Bernard, Paku, Sándor, Rozsas, Anita, Rényi-Vámos, Ferenc, Torok, Szilvia, Tóvári, József   +15 more
core   +3 more sources