Results 101 to 110 of about 27,751 (253)

A Rare Cause of Massive Scrotal Elephantiasis: Case Report and Literature Review

Trends in Urology &Men's Health, Volume 16, Issue 6, December 2025.
ABSTRACT Scrotal lymphedema is a rare late complication of testicular cancer treatment, with most reported cases occurring in the early postoperative period. Massive scrotal elephantiasis manifesting more than a decade after postchemotherapy retroperitoneal lymph node dissection (pc‐RPLND) has not previously been described.
David Toro Tole, Jonathon Bowden, Bilal Mir, Joe Hedger, Sheshang Kamath   +4 more
wiley   +1 more source

Adrenomedullin Induces Cardiac Lymphangiogenesis After Myocardial Infarction and Regulates Cardiac Edema Via Connexin 43

Circulation Research, 2019
Rationale: Cardiac lymphangiogenesis contributes to the reparative process post-myocardial infarction, but the factors and mechanisms regulating it are not well understood.
Claire E. Trincot, Wenjing Xu, Hua Zhang, Molly R. Kulikauskas, T. Caranasos, B. Jensen, A. Sabine, T. Petrova, K. Caron   +8 more
semanticscholar   +1 more source

Elucidating the Anticancer Mechanisms of Tetrahydroxycurcumin: A Comprehensive Review of Preclinical Studies

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
Tetrahydroxycurcumin is an attractive multifunctional compound in cancer‐driven therapeutics. Its anticancer potential in modulating a wide range of oncogenic signaling networks, combined with its dual properties as an antioxidant and anti‐inflammatory agent, highlights its potential to become a transformative anticancer drug.
Muhammad Shahbaz, Ushna Momal, Hagar M. Mohamed, Asfa Perween, Hammad Naeem, Muhammad Imran, Muzzamal Hussain, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Tadesse Fenta Yehuala, Suliman A. Alsagaby, Waleed Al Abdulmonem, Mohamed A. Abdelgawad, Ehab M. Mostafa, Samy Selim   +14 more
wiley   +1 more source

The immune regulatory role of lymphangiogenesis in kidney disease

Journal of Translational Medicine
The renal lymphatic system is critical for maintaining kidney homeostasis and regulating the immune response inside the kidney. In various kidney pathological situations, the renal lymphatic network experiences lymphangiogenesis, which is defined as the ...
Xiangheng Lu, Kuai Ma, Junyi Ren, Haoyu Peng, Jia Wang, Xiaoxiao Wang, Moussa Ide Nasser, Chi Liu   +7 more
doaj   +1 more source

Podoplanin Expression and the Risk of Malignant Transformation of Oral Pre‐Malignant Disease: A Systematic Review and Meta‐Analysis

Head &Neck, Volume 47, Issue 11, Page 3185-3192, November 2025.
ABSTRACT Background Podoplanin is a mucin‐like transmembrane glycoprotein expressed in oral epithelium with a documented role in cell motility, tumorigenesis, tumor invasion, and metastasis. Podoplanin is a potentially valuable biomarker for determining malignant transformation of oral premalignant disease (OPMD).
Erin E. Briggs, Nathaniel Schlosser, Shaun A. Nguyen, Evan Graboyes, Jason G. Newman, Alexandra E. Kejner, Greer Albergotti, Michael Bobian, Angela Yoon, Yuri Peterson, Dauren Adilbay   +10 more
wiley   +1 more source

Human Lymphatic Endothelial Cells Expressing NRASQ61R Model Characteristics of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, Volume 72, Issue 11, November 2025.
ABSTRACT Kaposiform lymphangiomatosis (KLA) is a complex lymphatic anomaly characterized by lymphatic overgrowth and dysfunction. The goal of this study was to determine how the NRASQ61R variant found in the tissue of KLA patients impacts key characteristics of lymphatic endothelial cells (LEC).
Dermot A. Fox, C. Griffin McDaniel, Patricia Pastura, Timothy D. Le Cras   +3 more
wiley   +1 more source

The Role of Stromal Tumor Environment in Advancing Skin Cancer Diagnosis and Treatment

International Journal of Dermatology, Volume 64, Issue 11, Page 2019-2028, November 2025.
ABSTRACT The stromal tumor environment (STE) plays a vital yet often underrecognized role in cancer progression, shaping tumor development. It influences complex interactions among stromal cells, immune cells, extracellular matrix (ECM) components, and signaling molecules.
Frank Jing, Ani Pazhava, Catherine Shachaf, Alexander Meves   +3 more
wiley   +1 more source

CCBE1 promotes tumor lymphangiogenesis and is negatively regulated by TGFβ signaling in colorectal cancer

Theranostics, 2020
Collagen and calcium-binding EGF domain-1 (CCBE1) is essential for lymphatic vascular development as it promotes vascular endothelial growth factor C (VEGFC) proteolysis.
Jinglue Song, Wei Chen, Xuewei Cui, Zhenyu Huang, Dongpeng Wen, Yili Yang, Wei Yu, L. Cui, Chen-Ying Liu   +8 more
semanticscholar   +1 more source

Reprogramming lymphatic endothelial glucose metabolism for the treatment of lymphangiogenesis-related disease

Pharmacological Research
Lymphangiogenesis plays important roles in the pathogenesis of several human diseases, including keratitis, transplant rejection, and cancers. Dysregulated glucose metabolism has emerged as a critical driver of pathological lymphangiogenesis.
Ziran Zhang, Fan Ye, Huiying Zhang, Xiumiao Li, Wan Mu, Keran Li, Biao Yan   +6 more
doaj   +1 more source

Foxp3 is correlated with VEGF-C expression and lymphangiogenesis in cervical cancer

World Journal of Surgical Oncology, 2017
Background Recent observations revealed Foxp3 participated in the development of cervical cancer. Furthermore, Foxp3 has a vital function in the lymphatic metastasis of cervical cancer.
Jiabu Tang, Zheng Yang, Zhuo Wang, Zhen Li, Hongmei Li, Jinbao Yin, Min Deng, Wei Zhu, Chao Zeng   +8 more
doaj   +1 more source