Results 101 to 110 of about 43,762 (300)

A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. [PDF]

, 2016
mTOR inhibition has emerged as a promising strategy for head and neck squamous cell carcinomas (HNSCC) treatment. However, most targeted therapies ultimately develop resistance due to the activation of adaptive survival signaling mechanisms limiting the ...
Amornphimoltham, Panomwat, Califano, Joseph A, Callejas-Valera, Juan Luis, Cohen, Ezra E, Gutkind, J Silvio, Iglesias-Bartolomé, Ramiro, Lippman, Scott M, Luo, Ji, Molinolo, Alfredo A, Wang, Zhiyong, Yamaguchi, Kosuke   +10 more
core   +1 more source

Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression

Advanced Science, EarlyView.
This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang, Shucheng Jin, Penghui Guo, Yuying Yin, Yichun Hua, Xiaosheng Ding, Zhe Zhang, Shuo Chen, Xu Han, Baowang Li, Yan Liu, Xiaoyan Li, Deling Li, Jing Jing, Wei Shi, Wang Jia   +15 more
wiley   +1 more source

Targeting glycolytic reprogramming by tsRNA-0032 for treating pathological lymphangiogenesis

Cell Death and Disease
Lymphangiogenesis is vital for tissue fluid homeostasis, immune function, and lipid absorption. Abnormal lymphangiogenesis has been implicated in several diseases such as cancers, inflammatory, and autoimmune diseases.
Fan Ye, Ziran Zhang, Lianjun Shi, Shuting Lu, Xiumiao Li, Wan Mu, Qin Jiang, Biao Yan   +7 more
doaj   +1 more source

Extracellular vesicle-associated VEGF-C promotes lymphangiogenesis and immune cells infiltration in endometriosis

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Endometriosis is a highly prevalent proinflammatory disease without reliable diagnostic biomarkers and cannot be cured by nowadays’ medical treatments.
Wan-Ning Li, Kuei-Yang Hsiao, Chu-An Wang, Ning Chang, Pei-Ling Hsu, Chung-hsien Sun, Shang-Rung Wu, Meng-Hsing Wu, S. Tsai   +8 more
semanticscholar   +1 more source

Tumor Extracellular Vesicles lncOSLMT Drives Lung Inflammatory Premetastatic Niche Formation in Osteosarcoma via m6A‐Dependent hnRNPA2B1/COX‐2 Axis

Advanced Science, EarlyView.
Tumor‐derived extracellular vesicles program inflammatory lung premetastatic niches through selective delivery of long noncoding RNAs. This work reveals EVs‐associated lncOSLMT as a key driver of lung fibroblast activation via m6A‐dependent PTGS2 stabilization.
Hongbo Li, Zehao Guo, Yutong Zou, Jiongfeng Zhang, Jixiang Shi, Xihong Fu, Jian Tu, Hao Yao, Xuanxuan Lu, Lili Wen, Xianbiao Xie   +10 more
wiley   +1 more source

EphrinB2-mediated CDK5/ISL1 pathway enhances cardiac lymphangiogenesis and alleviates ischemic injury by resolving post-MI inflammation

Signal Transduction and Targeted Therapy
EphrinB2 (erythropoietin-producing hepatoma interactor B2) is a key Eph/ephrin family member, promoting angiogenesis, vasculogenesis, and lymphangiogenesis during embryonic development. However, the role of EphrinB2 in cardiac lymphangiogenesis following
Yingnan Bai, Liming Chen, Fanghao Guo, Jinghong Zhang, Jinlin Hu, Xuefei Tao, Qing Lu, Wenyi Li, Xueying Chen, Ting Gong, Nan Qiu, Yawei Jin, Lifan Yang, Yu Lei, Chengchao Ruan, Qing Jing, John P. Cooke, Shijun Wang, Yunzeng Zou, Junbo Ge   +19 more
doaj   +1 more source

Atypical E2fs control lymphangiogenesis through transcriptional regulation of Ccbe1 and Flt4. [PDF]

PLoS ONE, 2013
Lymphatic vessels are derived from venous endothelial cells and their formation is governed by the Vascular endothelial growth factor C (VegfC)/Vegf receptor 3 (Vegfr3; Flt4) signaling pathway.
Bart G M W Weijts, Andreas van Impel, Stefan Schulte-Merker, Alain de Bruin   +3 more
doaj   +1 more source

Novel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signalling pathway [PDF]

, 2016
BACKGROUND AND PURPOSE Lymphangiogenesis is an important biological process associated with the pathogenesis of several diseases, including metastatic dissemination, graft rejection, lymphoedema and other inflammatory disorders.
Blacher, S., García-Caballero, Melissa, Medina, Miguel Ángel, Nöel, Agnes, Pauper, J., Quesada, Ana R.   +5 more
core  

Transcriptomic Profiles of Monocyte-Derived Macrophages in Response to Escherichia coli is Associated with the Host Genetics. [PDF]

, 2020
Reactive Nitrogen Species (RNS) are a group of bactericidal molecules produced by macrophages in response to pathogens in a process called oxidative burst.
Cánovas, Angela, Emam, Mehdi, Fonseca, Pablo AS, Islas-Trejo, Alma D, Mallard, Bonnie, Medrano, Juan F   +5 more
core  

Apelin promotes lymphangiogenesis and lymph node metastasis [PDF]

, 2014
International ...
Berger, Walter, Berta, Judit, Döme, Balázs, Garay, Tamás, Groger, Marion, Grusch, Michael, Hegedűs, Balázs, Hoda, Mir Alireza, Klepetko, Walter, Laszlo, Viktória, Masri, Bernard, Paku, Sándor, Rozsas, Anita, Rényi-Vámos, Ferenc, Torok, Szilvia, Tóvári, József   +15 more
core   +4 more sources