Results 101 to 110 of about 23,756 (251)

Defective lymphatic vasculature in obesity

Obesity Reviews, Volume 26, Issue 8, August 2025.
Summary Lymphedema is an important, and often underdiagnosed complication of obesity and is likely due to acquired defects in the lymphatic vasculature. Study of diet‐induced obesity animal models have indicated defective lymphatic vasculatures might extend to other anatomical sites, especially visceral depots.
Jingjing Zhu, John P. H. Wilding, Ji Hu
wiley   +1 more source

Lymphangiogenesis induced by vascular endothelial growth factor receptor 1 signaling contributes to the progression of endometriosis in mice

Journal of Pharmacological Sciences, 2020
Lymphangiogenesis is related to the growth of endometriosis. Here, we examined whether vascular endothelial growth factor (VEGF) receptor 1 (VEGFR1) signaling plays a role in lymphangiogenesis during endometriosis.
Kyoko Hattori, Yoshiya Ito, Masako Honda, Kazuki Sekiguchi, Kanako Hosono, Masabumi Shibuya, Nobuya Unno, Masataka Majima   +7 more
doaj  

Nuclear Receptor ERRγ Protects Against Cardiac Ischemic Injury by Suppressing GBP5‐Mediated Myocardial Inflammation

The FASEB Journal, Volume 39, Issue 14, 31 July 2025.
Cardiomyocyte‐specific overexpression of ERRγ after myocardial infarction improves cardiac function by suppressing the expression of its pro‐inflammatory downstream target GBP5, thereby inhibiting inflammasome assembly, alleviating myocardial inflammation, and pyroptosis.
Junhao Qiu, Qianji Che, Yichao Zhang, Mu Chen, Zhixing Wei, Yangjinming Bai, Tingting Zhao, Ji Yan, Zhengyang Wu, Zhentao Fei, Yuepeng Wang, Qian Wang, Yi‐Gang Li   +12 more
wiley   +1 more source

Expression and Prognostic Value of VEGF-C and Lymphangeogenesis 
in Lung Adenocarcinoma and Squamous Cell Carcinoma

Chinese Journal of Lung Cancer, 2011
Background and objective Vascular endothelial growth factor-C (VEGF-C), a member of the VEGF family, has been proven to be a relatively special VEGF. When binding to its receptor VEGFR-3, it activates lymphangiogenesis, which likely induces lymph node ...
Xueli DAI, Wenli WANG, Yang SHEN-TU, Jie ZHANG   +3 more
doaj   +1 more source

Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis

Frontiers in Oncology, 2019
Non-coding RNAs (ncRNAs), which do not encode proteins, have pivotal roles in manipulating gene expression in development, physiology, and pathology. Emerging data have shown that ncRNAs can regulate lymphangiogenesis, which refers to lymphatics deriving
Ming-xin Cao, Ya-ling Tang, Wei-long Zhang, Ya-Jie Tang, Ya-Jie Tang, Xin-hua Liang   +5 more
doaj   +1 more source

Role of lymphangiogenesis in lung cancer.

Folia Histochemica et Cytobiologica, 2010
Lung cancer represents one of the most frequent causes of death due to neoplastic disease in Poland and around the world. The high mortality which accompany neoplastic diseases used to be ascribed mainly to dissemination of cancerous cells.
Renata Jankowska, Piotr Dziegiel, Bozena Weryńska   +2 more
doaj   +1 more source

Lysyl Oxidase-Like Protein 2 Promotes Tumor Lymphangiogenesis and Lymph Node Metastasis in Breast Cancer

Neoplasia: An International Journal for Oncology Research, 2019
Tumor lymphangiogenesis has been previously documented to predict regional lymph node metastasis and promote the spread to distant organs. However, the underlying mechanism initiating tumor lymphangiogenesis remains unclear.
Chunying Wang, Siran Xu, Yang Tian, Anji Ju, Qiaoyun Hou, Jie Liu, Yan Fu, Yongzhang Luo   +7 more
doaj  

Lymphatic‐specific methyltransferase‐like 3‐mediated m6A modification drives vascular patterning through prostaglandin metabolism reprogramming

MedComm
Lymphangiogenesis plays a pivotal role in the pathogenesis of various vascular disorders, including ocular vascular diseases and cancers. Deregulation of N6‐methyladenosine (m6A) modification has been identified as a key contributor to human diseases ...
Lianjun Shi, Shuting Lu, Xue Han, Fan Ye, Xiumiao Li, Ziran Zhang, Qin Jiang, Biao Yan   +7 more
doaj   +1 more source

Phomaketide A Inhibits Lymphangiogenesis in Human Lymphatic Endothelial Cells

Marine Drugs, 2019
Lymphangiogenesis is an important biological process associated with cancer metastasis. The development of new drugs that block lymphangiogenesis represents a promising therapeutic strategy. Marine fungus-derived compound phomaketide A, isolated from the
Huai-Ching Tai, Tzong-Huei Lee, Chih-Hsin Tang, Lei-Po Chen, Wei-Cheng Chen, Ming-Shian Lee, Pei-Chi Chen, Chih-Yang Lin, Chih-Wen Chi, Yu-Jen Chen, Cheng-Ta Lai, Shiou-Sheng Chen, Kuang-Wen Liao, Chien-Hsing Lee, Shih-Wei Wang   +14 more
doaj   +1 more source

CEACAM1 increased the lymphangiogenesis through miR-423-5p and NF- kB in Non-Small Cell Lung Cancer

Biochemistry and Biophysics Reports
Background: Lung cancer causes significant mortality, with invasion and metastasis being the main features that cause most cancer deaths. Lymph node metastasis is the primary metastatic route in non-small cell carcinoma (NSCLC) and influences the staging
Jie Yu, Wenke Cai, Tao Zhou, Bo Men, Shunqiong Chen, Dong Tu, Wei Guo, Jicui Wang, Feipeng Zhao, Yan Wang   +9 more
doaj