Results 101 to 110 of about 33,222 (220)

A Phase 1/2 Study of Lenvatinib in Combination With Everolimus in Recurrent and Refractory Pediatric and Young Adult Solid Tumors

Pediatric Blood &Cancer, Volume 72, Issue 7, July 2025.
ABSTRACT Introduction Developing targeted therapies with manageable toxicities remains a high priority for pediatric cancer. We sought to determine the recommended Phase 2 dose (RP2D) and evaluate the antitumor activity of lenvatinib+everolimus in children/young adults with select recurrent/refractory solid tumors.
Filemon S. Dela Cruz, Elizabeth Fox, Steven G. DuBois, Gregory K. Friedman, James M. Croop, AeRang Kim, Daniel A. Morgenstern, Frank M. Balis, Margaret E. Macy, Joseph G. Pressey, Tanya Watt, Julie I. Krystal, Kieuhoa T. Vo, Rajen Mody, Theodore W. Laetsch, Brenda J. Weigel, Karen O'Hara, Cixin S. He, Jagadeesh Aluri, Chinyere E. Okpara, Julia L. Glade Bender   +20 more
wiley   +1 more source

The Role of VEGF family in angiogenesis, tumor growth and metastasis [PDF]

, 2014
Tumor growth is dependent on angiogenesis, and cells in tumor tissues produce various angiogenic factors to induce neovascularization. Among tumor-derived angiogenic factors, members of the vascular endothelial growth factor (VEGF) family are most ...
Yang, Xiaojuan
core   +1 more source

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Advanced Science, Volume 12, Issue 21, June 5, 2025.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan   +16 more
wiley   +1 more source

MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis [PDF]

, 2016
Lymphangiogensis is involved in various pathological conditions, such as arthritis and cancer metastasis. Although many factors have been identified to stimulate lymphatic vessel growth, little is known about lymphangiogenesis inhibitors.
Cao, R, Cao, Y, Jin, G, Wong, HLX, Zhang, S, Zhou, Z   +5 more
core   +1 more source

Macrophages‐derived small extracellular vesicles regulate chondrocyte proliferation and affect osteoarthritis progression via upregulating Osteopontin expression

Journal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.
Abstract Small extracellular vesicles (sEVs) are considered promising gene‐delivery vehicles for the treatment of osteoarthritis (OA). This study aimed to explore the molecular mechanism by which M2 macrophage‐derived sEVs (M2‐sEVs) modulate chondrocyte proliferation and apoptosis, thereby affecting OA progression.
Min Tu, An‐Min Liu, Wei Huang, Dan Wang, Hou‐Qiong Chen, Xiao‐Yuan Hu   +5 more
wiley   +1 more source

Корекція гемореологічних порушень у хворих на цукровий діабет з використанням низькоінтенсивного лазерного опромінення крові [PDF]

, 2011
In mammals, the homeodomain transcription factor Prox1 acts as the central regulator of lymphatic cell fate. Its restricted expression in a subset of cardinal vein cells leads to a switch towards lymphatic specification and hence represents a ...
Duckers, Henricus, Fischer, Johanna C, Hermkens, Dorien M A, Ingham, Philip W, Ober, Elke A, Peterson-Maduro, Josi, Roukens, M Guy, Schulte-Merker, Stefan, van Impel, Andreas, Zhao, Zhonghua   +9 more
core   +3 more sources

Cell‐Type Deconvolution Reveals Dynamic Changes in MASLD

Liver International Communications, Volume 6, Issue 2, June 2025.
ABSTRACT Metabolic‐associated steatotic liver disease (MASLD) is among the most prevalent liver disorders worldwide, with many patients progressing to metabolic‐associated steatohepatitis (MASH) characterised by fibrosis and inflammation. The current lack of effective treatments for MASH highlights the urgent need to deepen our understanding of its ...
Jeff J. H. Kim, Yang Dai
wiley   +1 more source

Lymphangiogenèse et progression tumorale [PDF]

, 2007
National audienceNumerous data show a functional link between lymphangiogenesis, lymph node invasion by tumoral cells and metastasis. During the last decade, the identification of lymphatic endothelial cell-specific markers has allowed the investigation ...
Feige, Jean-Jacques, Vittet, Daniel
core   +1 more source

Transcriptomic Profiles of Monocyte-Derived Macrophages in Response to Escherichia coli is Associated with the Host Genetics. [PDF]

, 2020
Reactive Nitrogen Species (RNS) are a group of bactericidal molecules produced by macrophages in response to pathogens in a process called oxidative burst.
Cánovas, Angela, Emam, Mehdi, Fonseca, Pablo AS, Islas-Trejo, Alma D, Mallard, Bonnie, Medrano, Juan F   +5 more
core  

Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis. [PDF]

, 2017
Lymphatic growth (lymphangiogenesis) within lymph nodes functions to promote dendritic cell entry and effector lymphocyte egress in response to infection or inflammation.
Dubey, L.K., Harris, N.L., Karempudi, P., Ludewig, B., Luther, S.A.   +4 more
core   +2 more sources