Results 41 to 50 of about 16,311 (176)
Molecular Carcinogenesis, EarlyView.ABSTRACT Oral squamous cell carcinoma (OSCC) is a prevalent type of cancer in the head and neck region, significantly impacting patient survival rates and quality of life. Lymph node (LN) metastasis is a lead contributor to the poor prognosis associated with OSCC.
Chengzhi Zhao +6 more
wiley +1 more source
Nectin4‐targeted molecular imaging in solid tumors: Current status and future perspectives
VIEW, EarlyView.In this review, we provide a concise overview of the mechanisms by which Nectin4 contributes to the pathogenesis of various malignancies and detail the classes of Nectin4‐targeted molecular probes. We then delve into the significant advancements in Nectin4‐targeted molecular imaging techniques, encompassing both nuclear medicine and optical imaging ...
Yongshun Liu +6 more
wiley +1 more source
Exercise‐Induced Cardiac Lymphatic Remodeling Mitigates Inflammation in the Aging Heart
Aging Cell, EarlyView.Exercise improves cardiac lymphatic architecture and function in the aged mouse. Aged hearts show reduced lymphatic vascular density, more dilated vessels, and increased peri‐lymphatic inflammation and fibrosis. Exercise training of the aged mouse increases lymph vessel density and sprouting, reverses their dilation, reduces inflammation and fibrosis ...
Kangsan Roh +19 more
wiley +1 more source
Cell Transplantation, 2022 Extracellular vesicles from adipose-derived mesenchymal stem cells (ADSCs) play an important role in lymphangiogenesis; however, the underlying mechanisms are not fully understood.
Yi Yang +8 more
doaj +1 more source
Biomedicines, 2021 Chondrosarcoma is a malignant bone tumor with high metastatic potential. Lymphangiogenesis is a critical biological step in cancer metastasis. WNT1-inducible signaling pathway protein 3 (WISP-3) regulates angiogenesis and facilitates chondrosarcoma ...
Chih-Yang Lin +9 more
doaj +1 more source
Targeted Therapies for Slow‐Flow Vascular Malformations
Australasian Journal of Dermatology, EarlyView.ABSTRACT Advances in genetic sequencing technologies have enabled the identification of key activating somatic variants in cellular signalling pathways involved in the pathogenesis of vascular malformations. Given that these genetic variants are also implicated in the pathogenesis of several cancers, the repurposing of targeted therapies developed in ...
Grace X. Li +2 more
wiley +1 more source
Scientific Reports, 2017 Lymphangiogenesis is essential for fluid homeostasis in vascularized tissues. In the normally avascular cornea, however, pathological lymphangiogenesis mediates diseases like corneal transplant rejection, dry eye disease, and allergy.
Deniz Hos +10 more
doaj +1 more source
CCN2-induced lymphangiogenesis is mediated by the integrin αvβ5–ERK pathway and regulated by DUSP6
Scientific Reports, 2022 Lymphangiogenesis is essential for the development of the lymphatic system and is important for physiological processes such as homeostasis, metabolism and immunity.
Shiho Hashiguchi +4 more
doaj +1 more source
Exploring Long Noncoding RNAs as Regulators of Tumor Ferroptosis: Advances and Challenges
Cancer Science, EarlyView.Long noncoding RNAs (lncRNAs) play pivotal roles in regulating gene expression and are closely associated with cancer progression, prognosis, and therapeutic resistance. This review highlights recent advancements in understanding how lncRNAs modulate ferroptosis, a regulated form of cell death characterized by iron‐dependent lipid peroxidation ...
Gang Li +3 more
wiley +1 more source
Spatio-temporal Models of Lymphangiogenesis in Wound Healing [PDF]
arXiv, 2016 Several studies suggest that one possible cause of impaired wound healing is failed or insufficient lymphangiogenesis, that is the formation of new lymphatic capillaries. Although many mathematical models have been developed to describe the formation of blood capillaries (angiogenesis), very few have been proposed for the regeneration of the lymphatic ...
arxiv