Results 41 to 50 of about 27,751 (253)

Lymphangiogenesis-inducing vaccines elicit potent and long-lasting T cell immunity against melanomas

Science Advances, 2021
New approach for immune cell recruitment in therapeutic anticancer vaccines drives antigenically broad and long-lasting immunity. In melanoma, the induction of lymphatic growth (lymphangiogenesis) has long been correlated with metastasis and poor ...
M. Sasso, Nikolaos Mitrousis, Yue Wang, P. Briquez, S. Hauert, J. Ishihara, J. Hubbell, M. Swartz   +7 more
semanticscholar   +1 more source

Evolutionary Differences in the Vegf/Vegfr Code Reveal Organotypic Roles for the Endothelial Cell Receptor Kdr in Developmental Lymphangiogenesis

Cell Reports, 2019
Summary: Lymphatic vascular development establishes embryonic and adult tissue fluid balance and is integral in disease. In diverse vertebrate organs, lymphatic vessels display organotypic function and develop in an organ-specific manner. In all settings,
Adam J. Vogrin, Neil I. Bower, Menachem J. Gunzburg, Sally Roufail, Kazuhide S. Okuda, Scott Paterson, Stephen J. Headey, Steven A. Stacker, Benjamin M. Hogan, Marc G. Achen   +9 more
doaj   +1 more source

Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis

Nature Communications, 2021
Autophagy has vasculoprotective roles, but whether and how it regulates lymphatic endothelial cells (LEC) homeostasis and lymphangiogenesis is unknown.
O. Meçe, Diede Houbaert, M. Sassano, Tania Durré, H. Maes, Marco B. E. Schaaf, S. More, Maarten Ganne, Melissa García-Caballero, M. Borri, J. Verhoeven, M. Agrawal, Kathryn A Jacobs, G. Bergers, S. Blacher, B. Ghesquière, M. Dewerchin, Johan V. Swinnen, S. Vinckier, M. Soengas, P. Carmeliet, A. Noël, P. Agostinis   +22 more
semanticscholar   +1 more source

ADSCs enhance VEGFR3-mediated lymphangiogenesis via METTL3-mediated VEGF-C m6A modification to improve wound healing of diabetic foot ulcers

Molecular Medicine, 2021
Adipose-derived mesenchymal stem cells (ADSCs) are an important focus in regenerative medicine. However, the biological function of ADSCs in the wound repair of diabetic foot ulcers (DFUs) remains unclear.
Jie Zhou, Tianhong Wei, Zhiyou He
semanticscholar   +1 more source

Kuoxin Decoction promotes lymphangiogenesis in zebrafish and in vitro based on network analysis

Frontiers in Pharmacology, 2022
Background: Inadequate lymphangiogenesis is closely related to the occurrence of many kinds of diseases, and one of the important treatments is to promote lymphangiogenesis.
Longping Peng, Mengjiao Ma, Yidan Dong, Qiong Wu, Shiying An, Min Cao, Yi Wang, Chang Zhou, Maolin Zhou, Xu Wang, Qianqian Liang, Qianqian Liang, Qianqian Liang, Youhua Wang   +13 more
doaj   +1 more source

Regulation and impact of cardiac lymphangiogenesis in pressure-overload-induced heart failure

bioRxiv, 2021
Rationale Lymphatics are essential for cardiac health, and insufficient lymphatic expansion (lymphangiogenesis) contributes to development of heart failure (HF) after myocardial infarction. However, the regulation and impact of lymphatics in non-ischemic
C. Heron, A. Dumesnil, Mahmoud Houssari, S. Renet, T. Lemarcis, A. Lebon, D. Godefroy, D. Schapman, O. Henri, G. Riou, L. Nicol, J. Henry, M. Valet, Marie Pieronne-Deperrois, Antoine Ouvrard-Pascaud, Réné Hagerling, Hélène Chiavelli, Jean-Baptiste Michel, P. Mulder, S. Fraineau, V. Richard, V. Tardif, E. Brakenhielm   +22 more
semanticscholar   +1 more source

Lymphedema and Therapeutic Lymphangiogenesis

BioMed Research International, 2013
Lymphedema is a disorder of the lymphatic vascular system characterized by impaired lymphatic return and swelling of the extremities. Lymphedema is divided into primary and secondary forms based on the underlying etiology. Despite substantial advances in both surgical and conservative techniques, therapeutic options for the management of lymphedema are
Yukihiro Saito, Hironori Nakagami, Yasufumi Kaneda, Ryuichi Morishita   +3 more
openaire   +3 more sources

Lymphangiogenesis induced by vascular endothelial growth factor receptor 1 signaling contributes to the progression of endometriosis in mice

Journal of Pharmacological Sciences, 2020
Lymphangiogenesis is related to the growth of endometriosis. Here, we examined whether vascular endothelial growth factor (VEGF) receptor 1 (VEGFR1) signaling plays a role in lymphangiogenesis during endometriosis.
Kyoko Hattori, Yoshiya Ito, Masako Honda, Kazuki Sekiguchi, Kanako Hosono, Masabumi Shibuya, Nobuya Unno, Masataka Majima   +7 more
doaj   +1 more source

Lymphangiogenesis Guidance Mechanisms and Therapeutic Implications in Pathological States of the Cornea

Cells, 2023
Corneal lymphangiogenesis is one component of the neovascularization observed in several inflammatory pathologies of the cornea including dry eye disease and corneal graft rejection.
Mehul Patnam, Sunil R. Dommaraju, Faisal Masood, Paula Herbst, Jin-Hong Chang, Wen-Yang Hu, Mark I. Rosenblatt, Dimitri T. Azar   +7 more
doaj   +1 more source

Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis

International Journal of Cell Biology, 2012
In the 1970s, the late Judah Folkman postulated that tumors grow proportionately to their blood supply and that tumor angiogenesis removed this limitation promoting growth and metastasis. Work over the past 40 years, varying from molecular examination to
Jie Chen, J. Steven Alexander, A. Wayne Orr   +2 more
doaj   +1 more source