Results 61 to 70 of about 16,311 (176)

A Silk Fibroin Nanoparticle Hydrogel Loaded With NK1R Antagonist Has Synergistic Anti‐Inflammatory and Reparative Effects on Dry Eye Disease

Advanced Science, Volume 12, Issue 15, April 17, 2025.
This study develops a silk fibroin (SF) nanoparticles hydrogel targeting neurokinin 1 receptor with CP‐99994 (CP). Combining CP and SF to form stable nanoparticles while incorporating a flexible hydrogel material results in a sustained‐release ophthalmic drop formulation (SF@CP@Gel), which provides a long‐lasting ophthalmic formulation with anti ...
Bo Gong, Yi Liu, Huan Li, Xueming Ju, Dongfeng Li, Yuhao Zou, Xiaoxin Guo, Kai Dong, Jialing Xiao, Weijia Wu, Renjie Chai, Ruifan Zhang, Man Yu   +12 more
wiley   +1 more source

Lymphangiogenesis induced by vascular endothelial growth factor receptor 1 signaling contributes to the progression of endometriosis in mice

Journal of Pharmacological Sciences, 2020
Lymphangiogenesis is related to the growth of endometriosis. Here, we examined whether vascular endothelial growth factor (VEGF) receptor 1 (VEGFR1) signaling plays a role in lymphangiogenesis during endometriosis.
Kyoko Hattori, Yoshiya Ito, Masako Honda, Kazuki Sekiguchi, Kanako Hosono, Masabumi Shibuya, Nobuya Unno, Masataka Majima   +7 more
doaj  

NAT10 Promotes Gastric Cancer Liver Metastasis by Modulation of M2 Macrophage Polarization and Metastatic Tumor Cell Hepatic Adhesion

Advanced Science, Volume 12, Issue 15, April 17, 2025.
The N‐acetyltransferase‐10 (NAT10)‐mediated mRNA N4‐acetylcytidine modification enhances the stability of CXCL2 and KLF5 mRNA. Then, secreted CXCL2 promotes M2 macrophage polarization and oncostatin M secretion, activating NAT10 expression via STAT3 signaling.
Chen Chen, Zhangding Wang, Qingfeng Lin, Mengmeng Li, Lei Xu, Yao Fu, Xiaoya Zhao, Zhuang Ma, Jiawen Xu, Shimeng Zhou, Mingyue Zhang, Yun Qian, Linsen Bao, Bo Wang, Meng Wang, Qingqing Ding, Qiang Wang, Shouyu Wang   +17 more
wiley   +1 more source

A Serum Resistant Polymer with Exceptional Endosomal Escape and mRNA Delivery Efficacy for CRISPR Gene Therapy

Advanced Science, Volume 12, Issue 13, April 3, 2025.
A fluoropolymer, FD17, identified in a polymer library, exhibits exceptional serum stability and endosomal escape, enabling efficient mRNA delivery. FD17 facilitates the intracellular delivery of mRNAs encoding CRE, Cas9, and hyCBE for genome editing.
Jia Lv, Qianqian Fan, Yirou Zhang, Xujiao Zhou, Panting Yu, Xin Yu, Changchang Xin, Jiaxu Hong, Yiyun Cheng   +8 more
wiley   +1 more source

Engineered Nanocatalyst‐Enabled Cheolesterol Depletion for Enhanced Tumor Piezocatalytic Therapy

Advanced Science, Volume 12, Issue 14, April 10, 2025.
Under ultrasound (US) irradiation, cholesterol oxidase (CHO)‐loaded Pt‐ZnO nanoparticles (Pt‐ZnO/CHO) initiates a piezo‐catalytic cascade reaction that produces oxygen (O2) and reactive oxygen species (ROS), leading to the consumption of cholesterol, disruption of lipid raft integrity, and interference with lamellipodia formation. This process inhibits
Mengdan Li, Yajun Zhou, Xiaoyang Chen, Weiwei Chen, Yifei Yang, Cheng Qian, Lei Yang, Yaohan Zhang, Zheng Zhang, Wencheng Wu, Yifei Yin   +10 more
wiley   +1 more source

Immunological Effects of Proton Radiotherapy: New Opportunities and Challenges in Cancer Therapy

Cancer Innovation, Volume 4, Issue 2, April 2025.
An overview of recent advances in the combined immunological effects of proton RT from cellular, animal and clinical aspects, and a presentation of the reported findings on the nature of proton RT and its radiobiological mechanisms, with a view to providing new ideas for proton RT combined with immunotherapy.
Anhang Zhang, Liyuan Fan, Qi Liu, Xiaoxin Zuo, Jian Zhu   +4 more
wiley   +1 more source

Expression and Prognostic Value of VEGF-C and Lymphangeogenesis 
in Lung Adenocarcinoma and Squamous Cell Carcinoma

Chinese Journal of Lung Cancer, 2011
Background and objective Vascular endothelial growth factor-C (VEGF-C), a member of the VEGF family, has been proven to be a relatively special VEGF. When binding to its receptor VEGFR-3, it activates lymphangiogenesis, which likely induces lymph node ...
Xueli DAI, Wenli WANG, Yang SHEN-TU, Jie ZHANG   +3 more
doaj   +1 more source

Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis

Frontiers in Oncology, 2019
Non-coding RNAs (ncRNAs), which do not encode proteins, have pivotal roles in manipulating gene expression in development, physiology, and pathology. Emerging data have shown that ncRNAs can regulate lymphangiogenesis, which refers to lymphatics deriving
Ming-xin Cao, Ya-ling Tang, Wei-long Zhang, Ya-Jie Tang, Ya-Jie Tang, Xin-hua Liang   +5 more
doaj   +1 more source

The role of cancer‐associated fibroblasts in the tumour microenvironment of urinary system

Clinical and Translational Medicine, Volume 15, Issue 4, April 2025.
We summarised the role of cancer‐associated fibroblasts (CAFs) in urological tumours, including their origin, exosomes and extracellular matrix (ECM). CAFs are derived from various precursor cells and can communicate with other cells to form a hypoxic and immunosuppressive microenvironment.
Ri Hong, Puguang Yu, Xiaoli Zhang, Peng Su, Hongyuan Liang, Dan Dong, Xuesong Wang, Kefeng Wang   +7 more
wiley   +1 more source

Role of lymphangiogenesis in lung cancer.

Folia Histochemica et Cytobiologica, 2010
Lung cancer represents one of the most frequent causes of death due to neoplastic disease in Poland and around the world. The high mortality which accompany neoplastic diseases used to be ascribed mainly to dissemination of cancerous cells.
Renata Jankowska, Piotr Dziegiel, Bozena Weryńska   +2 more
doaj   +1 more source