Results 11 to 20 of about 4,108,240 (367)

Continuous Modeling of T CD4 Lymphocyte Activation and Function [PDF]

Frontiers in Immunology, 2021
T CD4+ cells are central to the adaptive immune response against pathogens. Their activation is induced by the engagement of the T-cell receptor by antigens, and of co-stimulatory receptors by molecules also expressed on antigen presenting cells. Then, a
David Martínez-Méndez, Luis Mendoza, Luis Mendoza, Carlos Villarreal, Carlos Villarreal, Leonor Huerta   +5 more
doaj   +2 more sources

Biophysical aspects of T lymphocyte activation at the immune synapse

Frontiers in Immunology, 2016
T lymphocyte activation is a pivotal step of the adaptive immune response. It requires the recognition by T-cell receptors (TCR) of peptides presented in the context of major histocompatibility complex molecules (pMHC) present at the surface of antigen ...
Claire eHivroz
doaj   +2 more sources

Prognostic impact of a lymphocyte activation-associated gene signature in GBM based on transcriptome analysis [PDF]

PeerJ, 2021
Background Glioblastoma multiforme (GBM) is a highly, malignant tumor of the primary central nervous system. Patients diagnosed with this type of tumor have a poor prognosis.
Yujia Lan, Erjie Zhao, Xinxin Zhang, Xiaojing Zhu, Linyun Wan, Suru A, Yanyan Ping, Yihan Wang   +7 more
doaj   +3 more sources

Lactate dehydrogenase-elevating virus induces systemic lymphocyte activation via TLR7-dependent IFNalpha responses by plasmacytoid dendritic cells. [PDF]

PLoS ONE, 2009
BACKGROUND:Lactate dehydrogenase-elevating virus (LDV) is a natural infectious agent of mice. Like several other viruses, LDV causes widespread and very rapid but transient activation of both B cells and T cells in lymphoid tissues and the blood.
Christoph G Ammann, Ronald J Messer, Karin E Peterson, Kim J Hasenkrug   +3 more
doaj   +2 more sources

Mucosal Genomics Implicate Lymphocyte Activation and Lipid Metabolism in Refractory Environmental Enteric Dysfunction

Gastroenterology, 2021
Background & Aims Environmental enteric dysfunction (EED) limits the Sustainable Development Goals of improved childhood growth and survival. We applied mucosal genomics to advance our understanding of EED.
Y. Haberman, N. Iqbal, S. Ghandikota, I. Mallawaarachchi, T. Braun, P. Dexheimer, N. Rahman, R. Hadar, K. Sadiq, Z. Ahmad, Romana Idress, J. Iqbal, Sheraz Ahmed, A. Hotwani, F. Umrani, L. Ehsan, Gregory L. Medlock, S. Syed, C. Moskaluk, Jennie Z. Ma, A. Jegga, S. Moore, S. Ali, L. Denson   +23 more
semanticscholar   +1 more source

CTP Synthase 1 Is a Novel Therapeutic Target in Lymphoma

HemaSphere, 2023
Lymphoma is the most common hematological malignancy and is among the 10 most prevalent cancers worldwide. Although survival has been improved by modern immunochemotherapeutic regimens, there remains a significant need for novel targeted agents to treat ...
Hélène Asnagli, Norbert Minet, Christina Pfeiffer, Eef Hoeben, Rebecca Lane, David Laughton, Louise Birch, Geraint Jones, Andrew Novak, Andrew E. Parker, Heinz Ludwig, Alain Fischer, Sylvain Latour, Philip A. Beer   +13 more
doaj   +1 more source

FcγRI FG-loop functions as a pH sensitive switch for IgG binding and release

Frontiers in Immunology, 2023
Understanding the molecular mechanism underlying the hierarchic binding between FcγRs and IgG antibodies is critical for therapeutic antibody engineering and FcγR functions.
Jinghua Lu, Matthew Spencer, Zhongcheng Zou, Maria Traver, Joseph Brzostowski, Peter D. Sun   +5 more
doaj   +1 more source

Alterations in immunophenotype and metabolic profile of mononuclear cells during follow up in children with multisystem inflammatory syndrome (MIS-C)

Frontiers in Immunology, 2023
IntroductionAlthough children seem to be less susceptible to COVID-19, some of them develop a rare but serious hyperinflammatory condition called multisystem inflammatory syndrome in children (MIS-C).
Andreja Nataša Kopitar, Jernej Repas, Larisa Janžič, Maša Bizjak, Tina Tajnšek Vesel, Nina Emeršič, Mojca Zajc Avramovič, Alojz Ihan, Tadej Avčin, Tadej Avčin, Mojca Pavlin, Mojca Pavlin   +11 more
doaj   +1 more source

Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction

Nature Communications, 2021
Chimeric antigen receptor engineering in T cells has been shown to be of great potential therapeutic benefit in a range of immune pathologies, although the functionality of such cell therapies can be limited due to tonic signalling and the induction of ...
Baptiste Lamarthée, Armance Marchal, Soëli Charbonnier, Tifanie Blein, Juliette Leon, Emmanuel Martin, Lucas Rabaux, Katrin Vogt, Matthias Titeux, Marianne Delville, Hélène Vinçon, Emmanuelle Six, Nicolas Pallet, David Michonneau, Dany Anglicheau, Christophe Legendre, Jean-Luc Taupin, Ivan Nemazanyy, Birgit Sawitzki, Sylvain Latour, Marina Cavazzana, Isabelle André, Julien Zuber   +22 more
doaj   +1 more source

Reversal of splicing infidelity is a pre-activation step in B cell differentiation

Frontiers in Immunology, 2022
IntroductionB cell activation and differentiation is central to the adaptive immune response. Changes in exon usage can have major impacts on cellular signaling and differentiation but have not been systematically explored in differentiating B cells ...
Tina M. O’Grady, Melody Baddoo, Samuel A. Flemington, Eman Y. Ishaq, Nathan A. Ungerleider, Erik K. Flemington   +5 more
doaj   +1 more source