Results 41 to 50 of about 338,332 (265)

Non-canonical antigens are the largest fraction of peptides presented by MHC class I in mismatch repair deficient murine colorectal cancer

Genome Medicine
Background Immunotherapy based on checkpoint inhibitors is highly effective in mismatch repair deficient (MMRd) colorectal cancer (CRC). These tumors carry a high number of mutations, which are predicted to translate into a wide array of neoepitopes ...
Giuseppe Rospo, Rosaria Chilà, Vittoria Matafora, Veronica Basso, Simona Lamba, Alice Bartolini, Angela Bachi, Federica Di Nicolantonio, Anna Mondino, Giovanni Germano, Alberto Bardelli   +10 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

FLUORESCENT PROTEINS USING FOR LYMPHOCYTE ACTIVATION ASSAYING [PDF]

Biotechnologia Acta, 2013
Activation of immune cells is a key process in development of the specific immunity. The techniques for monitoring of the movement and the activity of signalling messengers and receptor proteins of lymphocytes in living cells and tissues are the ...
G. A. Lubchenko, R. G. Morev, L. S. Holodnaya, L. I. Ostapchenko   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Novel disulfide bond-mediated dimerization of the CARD domain was revealed by the crystal structure of CARMA1 CARD. [PDF]

PLoS ONE, 2013
CARMA1, BCL10 and MALT1 form a large molecular complex known as the CARMA1 signalosome during lymphocyte activation. Lymphocyte activation via the CARMA1 signalosome is critical to immune response and linked to many immune diseases. Despite the important
Tae-ho Jang, Jin Hee Park, Hyun Ho Park
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Neoadjuvant ultrahypofractionated radiotherapy with simultaneous integrated boost for glioblastoma: study protocol for a phase I multicenter clinical trial

BMC Cancer
Background The Stupp protocol standardized adjuvant radiotherapy (RT) with temozolomide as the best treatment after glioblastoma (GBM) resection. Later phase III trials found that moderate hypofractionation and ultrahypofractionation were not inferior in
Nadia Di Muzio, Miriam Torrisi, Raffaella Barzaghi, Arianna Pocaterra, Martina Mori, Filippo Folchini, Laura Giannini, Micol Valle, Michele Bailo, Chiara Lucrezia Deantoni, Silvia Snider, Filippo Gagliardi, Eliana Ruggiero, Sara Broggi, Luca Ruffino, Rossella Di Franco, Simona Mercogliano, Claudio Fiorino, Antonella Del Vecchio, Matteo Muto, Paolo Muto, Pietro Mortini, Anna Mondino, Andrei Fodor   +23 more
doaj   +1 more source

Early Diagnosis of Pathogen Infection by Cell-Based Activation Immunoassay

Cells, 2019
Diagnostic identification of pathogens is usually accomplished by isolation of the pathogen or its substances, and should correlate with the time and site of infection.
Erez Bar-Haim, Shahar Rotem, Uri Elia, Adi Bercovich-Kinori, Ma’ayan Israeli, Inbar Cohen-Gihon, Ofir Israeli, Noam Erez, Hagit Achdout, Ayelet Zauberman, Moshe Aftalion, Emanuelle Mamroud, Theodor Chitlaru, Ofer Cohen   +13 more
doaj   +1 more source

Lymphocyte Redox Imbalance and Reduced Proliferation after a Single Session of High Intensity Interval Exercise. [PDF]

PLoS ONE, 2016
This study investigated whether an acute session of high-intensity interval training (HIIT) is sufficient to alter lymphocyte function and redox status. Sixteen young healthy men underwent a HIIT session on a cycloergometer, consisting of eight bouts of ...
Rosalina Tossige-Gomes, Karine Beatriz Costa, Vinícius de Oliveira Ottone, Flávio de Castro Magalhães, Fabiano Trigueiro Amorim, Etel Rocha-Vieira   +5 more
doaj   +1 more source