Results 51 to 60 of about 506,913 (207)

Signaling in Lymphocyte Activation [PDF]

Cold Spring Harbor Perspectives in Biology, 2015
The fate of T and B lymphocytes, the key cells that direct the adaptive immune response, is regulated by a diverse network of signal transduction pathways. The T- and B-cell antigen receptors are coupled to intracellular tyrosine kinases and adaptor molecules to control the metabolism of inositol phospholipids and calcium release.
openaire   +3 more sources

Lactate dehydrogenase-elevating virus induces systemic lymphocyte activation via TLR7-dependent IFNalpha responses by plasmacytoid dendritic cells. [PDF]

PLoS ONE, 2009
BACKGROUND:Lactate dehydrogenase-elevating virus (LDV) is a natural infectious agent of mice. Like several other viruses, LDV causes widespread and very rapid but transient activation of both B cells and T cells in lymphoid tissues and the blood.
Christoph G Ammann, Ronald J Messer, Karin E Peterson, Kim J Hasenkrug   +3 more
doaj   +1 more source

Origin of lymph node-derived lymphocytes in human hepatic allografts [PDF]

, 1989
Hepatic allograft-derived lymph nodes were examined in the post-transplant period on order to determine the origin of lymphocytes and structural elements of the lymph node.
Chen, K, Demetris, AJ, Duquesnoy, RJ, Fung, JJ, Markus, B, Marrarri, M, Starzl, TE, Zeevi, A   +7 more
core   +1 more source

n-3 PUFA improves fatty acid composition, prevents palmitate-induced apoptosis, and differentially modifies B cell cytokine secretion in vitro and ex vivo

Journal of Lipid Research, 2010
n-3 polyunsaturated fatty acids (PUFAs) modify T-cell activation, in part by remodeling lipid composition; however, the relationship between n-3 PUFA and B-cell activation is unknown.
Benjamin Drew Rockett, Muhammad Salameh, Kristen Carraway, Kaitlin Morrison, Saame Raza Shaikh   +4 more
doaj   +1 more source

Non-canonical antigens are the largest fraction of peptides presented by MHC class I in mismatch repair deficient murine colorectal cancer

Genome Medicine
Background Immunotherapy based on checkpoint inhibitors is highly effective in mismatch repair deficient (MMRd) colorectal cancer (CRC). These tumors carry a high number of mutations, which are predicted to translate into a wide array of neoepitopes ...
Giuseppe Rospo, Rosaria Chilà, Vittoria Matafora, Veronica Basso, Simona Lamba, Alice Bartolini, Angela Bachi, Federica Di Nicolantonio, Anna Mondino, Giovanni Germano, Alberto Bardelli   +10 more
doaj   +1 more source

FLUORESCENT PROTEINS USING FOR LYMPHOCYTE ACTIVATION ASSAYING [PDF]

Biotechnologia Acta, 2013
Activation of immune cells is a key process in development of the specific immunity. The techniques for monitoring of the movement and the activity of signalling messengers and receptor proteins of lymphocytes in living cells and tissues are the ...
G. A. Lubchenko, R. G. Morev, L. S. Holodnaya, L. I. Ostapchenko   +3 more
doaj   +1 more source

Antigen-specific electrophoretic cell separation for immunological investigations [PDF]

, 1989
Preincubation of human blood lymphocytes with cell surface antigen specific antibodies under non-capping conditions reduces the electrophoretic mobility of the corresponding lymphocyte subpopulation.
Hannig, K., Hansen, Ernil, Wustrow, T. P.   +2 more
core   +1 more source

Lymphocyte subsets and the role of Th1/Th2 balance in stressed chronic pain patients [PDF]

, 2007
Background: The complex regional pain syndrome (CRPS) and fibromyalgia (FM) are chronic pain syndromes occurring in highly stressed individuals. Despite the known connection between the nervous system and immune cells, information on distribution of ...
Alexander Chouker, Antje Beyer, Avgustin B, Brogden KA, Bruehl S, Buske-Kirschbaum A, Bussone G, Caggiula AR, Christoph Eisner, Elenkov IJ, Gage JR, Geertzen JH, Gilman-Sachs A, Grande LA, Gustav Schelling, Hamaty D, Harden RN, Hennig J, Herbert TB, Hudson JI, Ines Kaufmann, Karlsson H, Kaufmann I, Leone M, Li M, Liblau RS, Maggio M, Manfred Thiel, Marchand F, Marx C, McEwen BS, Milosevic DB, Okada M, Pamuk ON, Peter Richter, Powell JM, Radstake TRDJ, Sacerdote P, Sanders VM, Sarzi-Puttini P, Schinkel C, Schwartzman RJ, Sgoutas-Emch SA, Smart JM, Smyth LJ, Stanton-Hicks M, Stefanski V, Stoll C, Tarcic N, Tournoy KG, Tournoy KG, Tsatsoulis A, Van de Vusse AC, Van Houdenhove B, Van Houdenhove B, Vidovic A, Volker Huge, Walker EA, Weisaeth L, Woiciechowsky C, Yunus MB   +60 more
core   +1 more source

Novel disulfide bond-mediated dimerization of the CARD domain was revealed by the crystal structure of CARMA1 CARD. [PDF]

PLoS ONE, 2013
CARMA1, BCL10 and MALT1 form a large molecular complex known as the CARMA1 signalosome during lymphocyte activation. Lymphocyte activation via the CARMA1 signalosome is critical to immune response and linked to many immune diseases. Despite the important
Tae-ho Jang, Jin Hee Park, Hyun Ho Park
doaj   +1 more source

STAT3 mutation impacts biological and clinical features of T-LGL leukemia [PDF]

, 2017
STAT3 mutations have been described in 30-40% of T-large granular lymphocyte (T-LGL) leukemia patients, leading to STAT3 pathway activation. Considering the heterogeneity of the disease and the several immunophenotypes that LGL clone may express, the aim
BARILA', GREGORIO, BERNO, TAMARA, BOSCARO, ELISA, CABRELLE, ANNA, CALABRETTO, GIULIA, DE MARCH, ELENA, ERCOLIN, CHIARA, FACCO, MONICA, GATTAZZO, CRISTINA, Lamy, Thierry, LEONCIN, MATTEO, Moignet, Aline, PAGNIN, ELISA, Pastoret, C\ue9dric, PIAZZA, FRANCESCO, Roussel, Mikael, SEMENZATO, GIANPIETRO CARLO, Teolato, Sara, TERAMO, ANTONELLA, TRENTIN, LIVIO, ZAMBELLO, RENATO   +20 more
core   +1 more source