Results 31 to 40 of about 1,928,223 (200)

Inherited Immunodeficiencies With High Predisposition to Epstein–Barr Virus-Driven Lymphoproliferative Diseases

Frontiers in Immunology, 2018
Epstein–Barr Virus (EBV) is a gamma-herpes virus that infects 90% of humans without any symptoms in most cases, but has an oncogenic potential, especially in immunocompromised individuals.
Sylvain Latour, Sylvain Latour, Sylvain Latour, Sarah Winter, Sarah Winter, Sarah Winter   +5 more
doaj   +1 more source

Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms [PDF]

, 2005
Integrins are adhesion receptors that are crucial to the functions of multicellular organisms. Integrin-mediated adhesion is a complex process that involves both affinity regulation and cytoskeletal coupling, but the molecular mechanisms behind this ...
Susanna C. Fagerholm, Fagerholm, Susanna C., Nurmi, SM, Hilden, Tiina J., Gahmberg, CG, Gahmberg, Carl G., Carl G. Gahmberg, Susanna M. Nurmi, Nurmi, Susanna M., Fagerholm, SC, Tiina J. Hilden, Hilden, TJ   +11 more
core   +1 more source

Lymphocyte subsets and the role of Th1/Th2 balance in stressed chronic pain patients [PDF]

, 2007
Background: The complex regional pain syndrome (CRPS) and fibromyalgia (FM) are chronic pain syndromes occurring in highly stressed individuals. Despite the known connection between the nervous system and immune cells, information on distribution of ...
Beyer, Antje, Thiel, Manfred, Richter, Peter, Huge, Volker, Schelling, Gustav, Chouker, Alexander, Kaufmann, Ines, Eisner, Christoph   +7 more
core   +1 more source

Hematopoietic stem cell transplantation as a curative treatment for Nck-associated protein 1-like (HEM1) deficiency: A first case reportFirst HSCT for HEM1 (NCKAP1L) deficiency [PDF]

Journal of Human Immunity
Thalhammer et al. report two siblings with hematopoietic protein 1 (HEM1), also named Nck-associated protein 1-like (NCKAP1L), deficiency and varying clinical phenotype and the first case of successful hematopoietic stem cell transplantation for ...
Julian Thalhammer, Bénédicte Bruno, Sylvain Latour, Benjamin Fournier, Wadih Abou Chahla   +4 more
doaj   +1 more source

T-Cell activation: a queuing theory analysis at low agonist density [PDF]

, 2006
We analyze a simple linear triggering model of the T-cell receptor (TCR) within the framework of queuing theory, in which TCRs enter the queue upon full activation and exit by downregulation.
Wedagedera, J.R., Burroughs, N.J., Burroughs, Nigel John, Wedagedera, J. R.   +3 more
core   +1 more source

T lymphocyte activation studies. [PDF]

, 2023
One of the most widely used tools for T lymphocyte activation is magnetic beads with immobilized IgG antibodies against CD3 and CD28 receptors. These antibodies provide two essential signals for T lymphocyte activation and stimulate their proliferation ...
Kaščicaitė-Radzivilova, Laura,
core  

HIV Patients Treated with Low-dose Prednisolone Exhibit Lower Immune Activation than Untreated Patients. [PDF]

, 2012
HIV-associated general immune activation is a strong predictor for HIV disease progression, suggesting that chronic immune activation may drive HIV pathogenesis. Consequently, immunomodulating agents may decelerate HIV disease progression.
Schmidt, Barabara, Albrecht Ulmer, Norbert Donhauser, Hartwig Klinker, Scheller Carsten, Scheller, Carsten, Kasang Christa, Barbara Schmidt, Stich, August, Schmidt, Barbara, Koutsilieri, Eleni, Ulmer Albrecht, Kalluvya, Samuel, Donhauser Norbert, Koutsilieri Eleni, Kalluvya Samuel, Klinker, Hartwig, Rethwilm, Axel, Axel Rethwilm, August Stich, Schmidt Barbara, Christa Kasang, Stich August, Ulmer, Albrecht, Klinker Hartwig, Samuel Kalluvya, Carsten Scheller, Donhauser, Norbert, Rethwilm Axel, Eleni Koutsilieri, Kasang, Christa   +30 more
core   +2 more sources

ORMDL3 modulates store-operated calcium entry and lymphocyte activation. [PDF]

, 2013
T lymphocytes rely on a Ca(2+) signal known as store-operated calcium entry (SOCE) for their activation. This Ca(2+) signal is generated by activation of a T-cell receptor, depletion of endoplasmic reticulum (ER) Ca(2+) stores and activation of Ca(2 ...
Carreras-Sureda, Amado, Rubio-Moscardo, Fanny, Kiefer, Kerstin, Valverde, Miguel A, Cantero-Recasens, Gerard, Peinelt, Christine, Niemeyer, Barbara A, Vicente, Rubén   +7 more
core   +2 more sources

CD122-targeted interleukin-2 and αPD-L1 treat bladder cancer and melanoma via distinct mechanisms, including CD122-driven natural killer cell maturation

OncoImmunology, 2021
Bladder cancer (BC) and melanoma are amenable to immune checkpoint blockade (ICB) therapy, yet most patients with advanced/metastatic disease do not respond. CD122-targeted interleukin (IL)-2 can improve ICB efficacy, but mechanisms are unclear.
Ryan M Reyes, Chenghao Zhang, Yilun Deng, Niannian Ji, Neelam Mukherjee, Alvaro S Padron, Curtis A Clark, Robert S Svatek, Tyler J Curiel   +8 more
doaj   +1 more source

Elevated monocyte HLA-DR in pediatric secondary hemophagocytic lymphohistiocytosis: a retrospective study

Frontiers in Immunology, 2023
IntroductionHemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition, and its diagnosis may be challenging. In particular, some cases show close similarities to sepsis (fever, organ failure, and high ferritin), but their treatment, while ...
Sylvain Raimbault, Guillaume Monneret, Morgane Gossez, Fabienne Venet, Alexandre Belot, Franck Zekre, Solene Remy, Etienne Javouhey   +7 more
doaj   +1 more source