Results 11 to 20 of about 506,913 (207)

LY-H as a potential screening biomarker for lymphocyte activation in peripheral blood [PDF]

Frontiers in Immunology
ObjectivesViral infections often cause morphological changes in peripheral blood lymphocytes. While the presence of reactive lymphocytes in blood smears reflects lymphocyte activation, their identification is often affected by morphological heterogeneity
Kang-chun-feng Qin, Chi-hui Yang, Yi-hui Zhang, Xin-yi Wang, Pei-pei Jin, Ning Ding   +5 more
doaj   +2 more sources

Continuous Modeling of T CD4 Lymphocyte Activation and Function [PDF]

Frontiers in Immunology, 2021
T CD4+ cells are central to the adaptive immune response against pathogens. Their activation is induced by the engagement of the T-cell receptor by antigens, and of co-stimulatory receptors by molecules also expressed on antigen presenting cells. Then, a
David Martínez-Méndez, Luis Mendoza, Luis Mendoza, Carlos Villarreal, Carlos Villarreal, Leonor Huerta   +5 more
doaj   +2 more sources

CD20 and CD19 targeted vectors induce minimal activation of resting B lymphocytes [PDF]

, 2013
B lymphocytes are an important cell population of the immune system. However, until recently it was not possible to transduce resting B lymphocytes with retro- or lentiviral vectors, making them unsusceptible for genetic manipulations by these vectors ...
A Pezzutto, A Yoder, AD Bucheit, B Anliker, C Demaison, C Frecha, C Frecha, C Frecha, CA Walshe, Christian J. Buchholz, CJ Buchholz, D Unutmaz, DA Tuveson, DD Sloan, Els Verhoeyen, Evren Alici, François-Loic Cosset, H Li, H Niiro, J Bruenke, J Uchida, JT Golay, K Akashi, K Itoh, L Ginaldi, M Fujimoto, M Kügler, M Peipp, M Serafini, M Zanetti, MD Mühlebach, Michael Schwenkert, MJ Polyak, MS Cragg, NE Harwood, Q Zhou, Q Zhou, Q Zhou, Qi Zhou, R Zufferey, RC Münch, RN Damle, RS Noyce, S Funke, S Kheirallah, S Kneissl, Sabrina Kneissl, T Nakamura, TF Tedder, X Li, Y Reiter, YD Korin   +51 more
core   +11 more sources

Inherited immunodeficiencies associated with proximal and distal defects in T cell receptor signaling and co-signaling

Biomedical Journal, 2022
T lymphocytes are central cells of adaptive immunity. Activation of T lymphocytes by the antigen receptor of T cells (TCR) and co-stimulatory molecules involve specific signaling components and cascades.
Sylvain Latour
doaj   +1 more source

Activation of lymphocytes [PDF]

Journal of Clinical Pathology, 1967
The technique involved in studying the activation of lymphocytes in the resting form, and their recognition as dividing and functional cells was studied, using phase contrast and agar as well as fluid culture. Standardization of technical methods was found to be essential, and the effect of variables was studied.
R J, Pulvertaft, I, Pulvertaft
openaire   +2 more sources

Differential roles of CTP synthetases CTPS1 and CTPS2 in cell proliferation

Life Science Alliance, 2023
The CTP nucleotide is essential for cell proliferation. This study explores the respective contributions of CTP synthetases 1 and 2 in cell proliferation.
Norbert Minet, Anne-Claire Boschat, Rebecca Lane, David Laughton, Philip Beer, Hélène Asnagli, Claire Soudais, Tim Bourne, Alain Fischer, Emmanuel Martin, Sylvain Latour   +10 more
doaj   +1 more source

FcγRI FG-loop functions as a pH sensitive switch for IgG binding and release

Frontiers in Immunology, 2023
Understanding the molecular mechanism underlying the hierarchic binding between FcγRs and IgG antibodies is critical for therapeutic antibody engineering and FcγR functions.
Jinghua Lu, Matthew Spencer, Zhongcheng Zou, Maria Traver, Joseph Brzostowski, Peter D. Sun   +5 more
doaj   +1 more source

CTP Synthase 1 Is a Novel Therapeutic Target in Lymphoma

HemaSphere, 2023
Lymphoma is the most common hematological malignancy and is among the 10 most prevalent cancers worldwide. Although survival has been improved by modern immunochemotherapeutic regimens, there remains a significant need for novel targeted agents to treat ...
Hélène Asnagli, Norbert Minet, Christina Pfeiffer, Eef Hoeben, Rebecca Lane, David Laughton, Louise Birch, Geraint Jones, Andrew Novak, Andrew E. Parker, Heinz Ludwig, Alain Fischer, Sylvain Latour, Philip A. Beer   +13 more
doaj   +1 more source

Alterations in immunophenotype and metabolic profile of mononuclear cells during follow up in children with multisystem inflammatory syndrome (MIS-C)

Frontiers in Immunology, 2023
IntroductionAlthough children seem to be less susceptible to COVID-19, some of them develop a rare but serious hyperinflammatory condition called multisystem inflammatory syndrome in children (MIS-C).
Andreja Nataša Kopitar, Jernej Repas, Larisa Janžič, Maša Bizjak, Tina Tajnšek Vesel, Nina Emeršič, Mojca Zajc Avramovič, Alojz Ihan, Tadej Avčin, Tadej Avčin, Mojca Pavlin, Mojca Pavlin   +11 more
doaj   +1 more source

Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction

Nature Communications, 2021
Chimeric antigen receptor engineering in T cells has been shown to be of great potential therapeutic benefit in a range of immune pathologies, although the functionality of such cell therapies can be limited due to tonic signalling and the induction of ...
Baptiste Lamarthée, Armance Marchal, Soëli Charbonnier, Tifanie Blein, Juliette Leon, Emmanuel Martin, Lucas Rabaux, Katrin Vogt, Matthias Titeux, Marianne Delville, Hélène Vinçon, Emmanuelle Six, Nicolas Pallet, David Michonneau, Dany Anglicheau, Christophe Legendre, Jean-Luc Taupin, Ivan Nemazanyy, Birgit Sawitzki, Sylvain Latour, Marina Cavazzana, Isabelle André, Julien Zuber   +22 more
doaj   +1 more source