Results 11 to 20 of about 338,332 (265)

Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction

Nature Communications, 2021
Chimeric antigen receptor engineering in T cells has been shown to be of great potential therapeutic benefit in a range of immune pathologies, although the functionality of such cell therapies can be limited due to tonic signalling and the induction of ...
Baptiste Lamarthée, Armance Marchal, Soëli Charbonnier, Tifanie Blein, Juliette Leon, Emmanuel Martin, Lucas Rabaux, Katrin Vogt, Matthias Titeux, Marianne Delville, Hélène Vinçon, Emmanuelle Six, Nicolas Pallet, David Michonneau, Dany Anglicheau, Christophe Legendre, Jean-Luc Taupin, Ivan Nemazanyy, Birgit Sawitzki, Sylvain Latour, Marina Cavazzana, Isabelle André, Julien Zuber   +22 more
doaj   +1 more source

Loss of RASGRP1 in humans impairs T‐cell expansion leading to Epstein‐Barr virus susceptibility

EMBO Molecular Medicine, 2018
Inherited CTPS1, CD27, and CD70 deficiencies in humans have revealed key factors of T‐lymphocyte expansion, a critical prerequisite for an efficient immunity to Epstein–Barr virus (EBV) infection.
Sarah Winter, Emmanuel Martin, David Boutboul, Christelle Lenoir, Sabah Boudjemaa, Arnaud Petit, Capucine Picard, Alain Fischer, Guy Leverger, Sylvain Latour   +9 more
doaj   +1 more source

Polysaccharide of Atractylodes macrocephala Koidz (PAMK) Alleviates Cyclophosphamide-induced Immunosuppression in Mice by Upregulating CD28/IP3R/PLCγ-1/AP-1/NFAT Signal Pathway

Frontiers in Pharmacology, 2020
The polysaccharide of Atractylodes macrocephala Koidz (PAMK) is recognized as an immune enhancer, with anti-cancer, anti-tumour, lymphocyte-activating and lymphocytes proliferation-inducing effects.
Xuelian Xiang, Nan Cao, Feiyue Chen, Long Qian, Yifei Wang, Yunmao Huang, Yunbo Tian, Danning Xu, Wanyan Li   +8 more
doaj   +1 more source

Prognostic impact of a lymphocyte activation-associated gene signature in GBM based on transcriptome analysis [PDF]

PeerJ, 2021
Background Glioblastoma multiforme (GBM) is a highly, malignant tumor of the primary central nervous system. Patients diagnosed with this type of tumor have a poor prognosis.
Yujia Lan, Erjie Zhao, Xinxin Zhang, Xiaojing Zhu, Linyun Wan, Suru A, Yanyan Ping, Yihan Wang   +7 more
doaj   +2 more sources

Inherited Immunodeficiencies With High Predisposition to Epstein–Barr Virus-Driven Lymphoproliferative Diseases

Frontiers in Immunology, 2018
Epstein–Barr Virus (EBV) is a gamma-herpes virus that infects 90% of humans without any symptoms in most cases, but has an oncogenic potential, especially in immunocompromised individuals.
Sylvain Latour, Sylvain Latour, Sylvain Latour, Sarah Winter, Sarah Winter, Sarah Winter   +5 more
doaj   +1 more source

Hematopoietic stem cell transplantation as a curative treatment for Nck-associated protein 1-like (HEM1) deficiency: A first case reportFirst HSCT for HEM1 (NCKAP1L) deficiency [PDF]

Journal of Human Immunity
Thalhammer et al. report two siblings with hematopoietic protein 1 (HEM1), also named Nck-associated protein 1-like (NCKAP1L), deficiency and varying clinical phenotype and the first case of successful hematopoietic stem cell transplantation for ...
Julian Thalhammer, Bénédicte Bruno, Sylvain Latour, Benjamin Fournier, Wadih Abou Chahla   +4 more
doaj   +1 more source

Signaling in Lymphocyte Activation [PDF]

Cold Spring Harbor Perspectives in Biology, 2015
The fate of T and B lymphocytes, the key cells that direct the adaptive immune response, is regulated by a diverse network of signal transduction pathways. The T- and B-cell antigen receptors are coupled to intracellular tyrosine kinases and adaptor molecules to control the metabolism of inositol phospholipids and calcium release.
openaire   +3 more sources

CD122-targeted interleukin-2 and αPD-L1 treat bladder cancer and melanoma via distinct mechanisms, including CD122-driven natural killer cell maturation

OncoImmunology, 2021
Bladder cancer (BC) and melanoma are amenable to immune checkpoint blockade (ICB) therapy, yet most patients with advanced/metastatic disease do not respond. CD122-targeted interleukin (IL)-2 can improve ICB efficacy, but mechanisms are unclear.
Ryan M Reyes, Chenghao Zhang, Yilun Deng, Niannian Ji, Neelam Mukherjee, Alvaro S Padron, Curtis A Clark, Robert S Svatek, Tyler J Curiel   +8 more
doaj   +1 more source

Elevated monocyte HLA-DR in pediatric secondary hemophagocytic lymphohistiocytosis: a retrospective study

Frontiers in Immunology, 2023
IntroductionHemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition, and its diagnosis may be challenging. In particular, some cases show close similarities to sepsis (fever, organ failure, and high ferritin), but their treatment, while ...
Sylvain Raimbault, Guillaume Monneret, Morgane Gossez, Fabienne Venet, Alexandre Belot, Franck Zekre, Solene Remy, Etienne Javouhey   +7 more
doaj   +1 more source

Intimate Partner Violence is Associated with Increased CD4+ T-Cell Activation Among HIV-Negative High-Risk Women

Pathogens and Immunity, 2016
Background: Biological pathways mediating the link between intimate partner violence (IPV) and increased HIV risk remain unexplored. We hypothesized that IPV-induced stress negatively affects HIV systemic immune defenses and aimed to evaluate whether IPV
Ameeta Shivdas Kalokhe, Chris C. Ibegbu, Surinder P. Kaur, Rama R. Amara, Mary E. Kelley, Carlos del Rio, Rob Stephenson   +6 more
doaj   +1 more source