Results 11 to 20 of about 1,928,223 (200)
Signaling in Lymphocyte Activation [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 The fate of T and B lymphocytes, the key cells that direct the adaptive immune response, is regulated by a diverse network of signal transduction pathways. The T- and B-cell antigen receptors are coupled to intracellular tyrosine kinases and adaptor molecules to control the metabolism of inositol phospholipids and calcium release.
Cantrell, Doreen
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LY-H as a potential screening biomarker for lymphocyte activation in peripheral blood [PDF]
Frontiers in ImmunologyObjectivesViral infections often cause morphological changes in peripheral blood lymphocytes. While the presence of reactive lymphocytes in blood smears reflects lymphocyte activation, their identification is often affected by morphological heterogeneity
Kang-chun-feng Qin +5 more
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Super-resolution imaging of T lymphocyte activation reveals chromatin decondensation and disrupted nuclear envelope [PDF]
Communications BiologyT lymphocyte activation plays a pivotal role in adaptive immune response and alters the spatial organization of nuclear architecture that subsequently impacts transcription activities.
Jianquan Xu +4 more
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Biomedical Journal, 2022 T lymphocytes are central cells of adaptive immunity. Activation of T lymphocytes by the antigen receptor of T cells (TCR) and co-stimulatory molecules involve specific signaling components and cascades.
Sylvain Latour
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Activation of lymphocytes [PDF]
Journal of Clinical Pathology, 1967 The technique involved in studying the activation of lymphocytes in the resting form, and their recognition as dividing and functional cells was studied, using phase contrast and agar as well as fluid culture. Standardization of technical methods was found to be essential, and the effect of variables was studied.
R J, Pulvertaft, I, Pulvertaft
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Differential roles of CTP synthetases CTPS1 and CTPS2 in cell proliferation
Life Science Alliance, 2023 The CTP nucleotide is essential for cell proliferation. This study explores the respective contributions of CTP synthetases 1 and 2 in cell proliferation.
Norbert Minet +10 more
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The Activation of Lymphocytes Is in Their CARMA [PDF]
Immunity, 2003 Lymphocyte activation via antigen receptors initiates adaptive immune responses. Two papers in this issue of Immunity demonstrate that CARMA-1, a CARD carrying member of the MAGUK family proteins, is essential for lymphocyte activation. CARMA-1 functions by coupling antigen receptor signals to NF-kappaB induction and JNK activation.
Abbas, Abul K, Sen, Ranjan
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FcγRI FG-loop functions as a pH sensitive switch for IgG binding and release
Frontiers in Immunology, 2023 Understanding the molecular mechanism underlying the hierarchic binding between FcγRs and IgG antibodies is critical for therapeutic antibody engineering and FcγR functions.
Jinghua Lu +5 more
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CTP Synthase 1 Is a Novel Therapeutic Target in Lymphoma
HemaSphere, 2023 Lymphoma is the most common hematological malignancy and is among the 10 most prevalent cancers worldwide. Although survival has been improved by modern immunochemotherapeutic regimens, there remains a significant need for novel targeted agents to treat ...
Hélène Asnagli +13 more
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Reversal of splicing infidelity is a pre-activation step in B cell differentiation
Frontiers in Immunology, 2022 IntroductionB cell activation and differentiation is central to the adaptive immune response. Changes in exon usage can have major impacts on cellular signaling and differentiation but have not been systematically explored in differentiating B cells ...
Tina M. O’Grady +5 more
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