Results 21 to 30 of about 359,313 (265)

Elevated monocyte HLA-DR in pediatric secondary hemophagocytic lymphohistiocytosis: a retrospective study

Frontiers in Immunology, 2023
IntroductionHemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition, and its diagnosis may be challenging. In particular, some cases show close similarities to sepsis (fever, organ failure, and high ferritin), but their treatment, while ...
Sylvain Raimbault, Guillaume Monneret, Morgane Gossez, Fabienne Venet, Alexandre Belot, Franck Zekre, Solene Remy, Etienne Javouhey   +7 more
doaj   +1 more source

Efecto de las infecciones oportunistas sobre las subpoblaciones de leucocitos en individuos infectados con el virus de inmunodeficiencia humana tipo 1

Biomédica: revista del Instituto Nacional de Salud, 2008
Introducción. La presencia de infecciones por patógenos oportunistas en pacientes con síndrome de inmunodeficiencia adquirida representa un coestímulo para acelerar la progresión de la infección por el VIH-1.
Carlos Julio Montoya, Zoraída Ramirez, Juan Carlos Cataño, Alejandro Román, María Teresa Rugeles   +4 more
doaj   +1 more source

CTPS2 regulates CTP synthetase activity by interacting with CTPS1

Life Science Alliance
The human CTP synthetases 1 and 2 associate together and co-localize in large filament–cytoophidium structures. CTPS1 and CTPS2 association results in enzymatic modulation independently of cytoophidia revealing a new regulation mechanism of CTP ...
Norbert Minet, Benoît Heid-Picard, Vanessa Masson, Damarys Loew, Emmanuel Martin, Sylvain Latour   +5 more
doaj   +1 more source

Antibody Repertoires Identify β-Tubulin as a Host Protective Parasite Antigen in Mice Infected With Trypanosoma cruzi

Frontiers in Immunology, 2018
Few studies investigate the major protein antigens targeted by the antibody diversity of infected mice with Trypanosoma cruzi. To detect global IgG antibody specificities, sera from infected mice were immunoblotted against whole T. cruzi extracts.
Fabricio Montalvão, Fabricio Montalvão, Danielle Oliveira Nascimento, Marise P. Nunes, Carolina M. Koeller, Alexandre Morrot, Alexandre Morrot, Leticia Miranda S. Lery, Paulo M. Bisch, Santuza M. R. Teixeira, Rita Vasconcellos, Leonardo Freire-de-Lima, Marcela F. Lopes, Norton Heise, George A. DosReis, Célio Geraldo Freire-de-Lima   +15 more
doaj   +1 more source

Impact of acute exercise on peripheral blood mononuclear cells nutrient sensing and mitochondrial oxidative capacity in healthy young adults

Physiological Reports, 2021
Regular exercise is associated with changes in peripheral blood mononuclear cell (PBMC) proportions that have enhanced effector functions in young and old adults; however, the effects of acute exercise on PBMC nutrient sensors and metabolic function in ...
Bailey Theall, James Stampley, Eunhan Cho, Joshua Granger, Neil M. Johannsen, Brian A. Irving, Guillaume Spielmann   +6 more
doaj   +1 more source

Multidrug transporter activity in lymphocytes [PDF]

British Journal of Pharmacology, 2004
Multidrug transporters play a dual role in haematopoietic cells, mediating the efflux of xenobiotics and regulating cell migration. For several reasons including the lack of specific antibodies, reports of multidrug transporter distribution on lymphocytes conflict. Murine B cells have been reported to completely lack transporter activity.
James I, Elliott, Selina, Raguz, Christopher F, Higgins   +2 more
openaire   +2 more sources

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice

Nature Communications
De novo synthesis of the pyrimidine, cytidine triphosphate (CTP), is crucial for DNA/RNA metabolism and depends on the CTP synthetases, CTPS1 and −2. Partial CTPS1 deficiency in humans has previously been shown to lead to immunodeficiency, with impaired ...
Claire Soudais, Romane Schaus, Camille Bachelet, Norbert Minet, Sara Mouasni, Cécile Garcin, Caique Lopes Souza, Pierre David, Clara Cousu, Hélène Asnagli, Andrew Parker, Paul Palmquist-Gomes, Fernando E. Sepulveda, Sébastien Storck, Sigolène M. Meilhac, Alain Fischer, Emmanuel Martin, Sylvain Latour   +17 more
doaj   +1 more source

n-3 PUFA improves fatty acid composition, prevents palmitate-induced apoptosis, and differentially modifies B cell cytokine secretion in vitro and ex vivo

Journal of Lipid Research, 2010
n-3 polyunsaturated fatty acids (PUFAs) modify T-cell activation, in part by remodeling lipid composition; however, the relationship between n-3 PUFA and B-cell activation is unknown.
Benjamin Drew Rockett, Muhammad Salameh, Kristen Carraway, Kaitlin Morrison, Saame Raza Shaikh   +4 more
doaj   +1 more source