Results 61 to 70 of about 1,928,223 (200)

Regulatory T-lymphocyte subsets in patients with HIV-infection receiving highly active antiretroviral therapy

Бюллетень сибирской медицины, 2019
Background. The reason why HIV-infected patients receiving highly active antiretroviral therapy (HAART) suffer from the increased immune activation remains elusive.
V. A. Chereshnev, E. V. Saidakova, L. B. Korolevskaya, N. G. Shmagel, K. V. Shmagel   +4 more
doaj   +1 more source

Lactate dehydrogenase-elevating virus induces systemic lymphocyte activation via TLR7-dependent IFNalpha responses by plasmacytoid dendritic cells. [PDF]

PLoS ONE, 2009
BACKGROUND:Lactate dehydrogenase-elevating virus (LDV) is a natural infectious agent of mice. Like several other viruses, LDV causes widespread and very rapid but transient activation of both B cells and T cells in lymphoid tissues and the blood.
Christoph G Ammann, Ronald J Messer, Karin E Peterson, Kim J Hasenkrug   +3 more
doaj   +1 more source

Non-canonical antigens are the largest fraction of peptides presented by MHC class I in mismatch repair deficient murine colorectal cancer

Genome Medicine
Background Immunotherapy based on checkpoint inhibitors is highly effective in mismatch repair deficient (MMRd) colorectal cancer (CRC). These tumors carry a high number of mutations, which are predicted to translate into a wide array of neoepitopes ...
Giuseppe Rospo, Rosaria Chilà, Vittoria Matafora, Veronica Basso, Simona Lamba, Alice Bartolini, Angela Bachi, Federica Di Nicolantonio, Anna Mondino, Giovanni Germano, Alberto Bardelli   +10 more
doaj   +1 more source

The cytolytic T lymphocyte response to the murine cytomegalovirus [PDF]

, 1984
Limiting dilution (LD) analysis with two modifications, the expansion and the restimulation LD assay, led to the detection and quantification of two distinct in vivo maturation stages within the lineage of virus- specific self-restricted CTL after ...
Reddehase, Matthias J., Koszinowski, Ulrich H., Keil, Günther M.   +2 more
core   +1 more source

Tissue typing by unidirectional mixed lymphocyte culture. 3. The relationship of in vitro lymphocyte compatibility to renal allograft rejection [PDF]

, 1971
We applied unidirectional MLC test to renal allograft in dogs, and investigated the correlation between the growth rates of MLC reaction and the intensity of rejection of the kidney transplants or the postoperative renal function.
Tsunemitsu, Kensuke
core   +1 more source

FLUORESCENT PROTEINS USING FOR LYMPHOCYTE ACTIVATION ASSAYING [PDF]

Biotechnologia Acta, 2013
Activation of immune cells is a key process in development of the specific immunity. The techniques for monitoring of the movement and the activity of signalling messengers and receptor proteins of lymphocytes in living cells and tissues are the ...
G. A. Lubchenko, R. G. Morev, L. S. Holodnaya, L. I. Ostapchenko   +3 more
doaj   +1 more source

Rapid and long-term disappearance of CD4+ T lymphocyte responses specific for Anaplasma marginale major surface protein-2 (MSP2) in MSP2 vaccinates following challenge with live A. marginale [PDF]

, 2005
In humans and ruminants infected with Anaplasma, the major surface protein 2 (MSP2) is immunodominant. Numerous CD4(+) T cell epitopes in the hypervariable and conserved regions of MSP2 contribute to this immunodominance.
Abbott, Jeffrey R, Howard, Chris J, Palmer, Guy H, Kegerreis, Kimberly A, Brown, Wendy C, Hope, Jayne; id_orcid, Hope, Jayne C, Hetrick, Peter F   +7 more
core   +1 more source

A nongenomic mechanism for progesterone-mediated immunosuppression: Inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes [PDF]

, 1998
The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive. Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and ...
Christopher M. Fanger, Khoury, Rosana M, Negulescu, Paul A, Cahalan, Michael D, Neben, Amber L, Hubert H. Kerschbaum, Fanger, Christopher M, Rosana M. Khoury, Kerschbaum, Hubert H, Claudia Eder, Amber L. Neben, George R. Ehring, Eder, Claudia, Michael D. Cahalan, Paul A. Negulescu, Ehring, George R, Negulescu, PA, Fanger, CM, Kerschbaum, HH, Khoury, RM, Ehring, GR, Eder, C, Cahalan, MD, Neben, AL   +23 more
core   +1 more source

Neoadjuvant ultrahypofractionated radiotherapy with simultaneous integrated boost for glioblastoma: study protocol for a phase I multicenter clinical trial

BMC Cancer
Background The Stupp protocol standardized adjuvant radiotherapy (RT) with temozolomide as the best treatment after glioblastoma (GBM) resection. Later phase III trials found that moderate hypofractionation and ultrahypofractionation were not inferior in
Nadia Di Muzio, Miriam Torrisi, Raffaella Barzaghi, Arianna Pocaterra, Martina Mori, Filippo Folchini, Laura Giannini, Micol Valle, Michele Bailo, Chiara Lucrezia Deantoni, Silvia Snider, Filippo Gagliardi, Eliana Ruggiero, Sara Broggi, Luca Ruffino, Rossella Di Franco, Simona Mercogliano, Claudio Fiorino, Antonella Del Vecchio, Matteo Muto, Paolo Muto, Pietro Mortini, Anna Mondino, Andrei Fodor   +23 more
doaj   +1 more source

Novel disulfide bond-mediated dimerization of the CARD domain was revealed by the crystal structure of CARMA1 CARD. [PDF]

PLoS ONE, 2013
CARMA1, BCL10 and MALT1 form a large molecular complex known as the CARMA1 signalosome during lymphocyte activation. Lymphocyte activation via the CARMA1 signalosome is critical to immune response and linked to many immune diseases. Despite the important
Tae-ho Jang, Jin Hee Park, Hyun Ho Park
doaj   +1 more source