Results 21 to 30 of about 4,108,240 (367)

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

Journal of Experimental Medicine, 2000
PD-1 is an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid cells. Mice deficient in PD-1 exhibit a breakdown of peripheral tolerance and demonstrate multiple autoimmune features.
G. Freeman, A. Long, Yoshiko Iwai, K. Bourque, T. Chernova, H. Nishimura, L. Fitz, Nelly Malenkovich, Taku Okazaki, M. Byrne, H. Horton, L. Fouser, L. Carter, V. Ling, M. Bowman, B. Carreno, M. Collins, C. Wood, T. Honjo   +18 more
semanticscholar   +1 more source

Inherited Immunodeficiencies With High Predisposition to Epstein–Barr Virus-Driven Lymphoproliferative Diseases

Frontiers in Immunology, 2018
Epstein–Barr Virus (EBV) is a gamma-herpes virus that infects 90% of humans without any symptoms in most cases, but has an oncogenic potential, especially in immunocompromised individuals.
Sylvain Latour, Sylvain Latour, Sylvain Latour, Sarah Winter, Sarah Winter, Sarah Winter   +5 more
doaj   +1 more source

Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3

Science, 2016
INTRODUCTION Parkinson’s disease (PD) is the second most common neurodegenerative disorder and leads to slowness of movement, tremor, rigidity, and, in the later stages of PD, cognitive impairment.
Xiaobo Mao, Michael T. Ou, Senthilkumar S. Karuppagounder, T. Kam, Xiling Yin, Yulan Xiong, Preston Ge, G. E. Umanah, Saurav Brahmachari, Joo-Ho Shin, H. Kang, Jianmin Zhang, Jin-chong Xu, Rong Chen, Hyejin Park, S. Andrabi, Sung-Ung Kang, R. A. Gonçalves, Yu Liang, Shu Zhang, C. Qi, S. Lam, J. A. Keiler, J. Tyson, Donghoon Kim, Nikhil Panicker, S. Yun, C. Workman, D. Vignali, V. Dawson, H. Ko, T. Dawson   +31 more
semanticscholar   +1 more source

Loss of RASGRP1 in humans impairs T‐cell expansion leading to Epstein‐Barr virus susceptibility

EMBO Molecular Medicine, 2018
Inherited CTPS1, CD27, and CD70 deficiencies in humans have revealed key factors of T‐lymphocyte expansion, a critical prerequisite for an efficient immunity to Epstein–Barr virus (EBV) infection.
Sarah Winter, Emmanuel Martin, David Boutboul, Christelle Lenoir, Sabah Boudjemaa, Arnaud Petit, Capucine Picard, Alain Fischer, Guy Leverger, Sylvain Latour   +9 more
doaj   +1 more source

Increased lymphocyte activation and atherosclerosis in CD47-deficient mice

Scientific Reports, 2019
CD47, also known as integrin-associated protein (IAP), is a transmembrane protein with multiple biological functions including regulation of efferocytosis and leukocyte trafficking.
D. Engelbertsen, Anu Autio, R. Verwilligen, M. Depuydt, G. Newton, S. Rattik, E. Levinsohn, G. Saggu, P. Jarolím, Huan Wang, Francisco E. Velázquez, A. Lichtman, F. Luscinskas   +12 more
semanticscholar   +1 more source

Inherited immunodeficiencies associated with proximal and distal defects in T cell receptor signaling and co-signaling

Biomedical Journal, 2022
T lymphocytes are central cells of adaptive immunity. Activation of T lymphocytes by the antigen receptor of T cells (TCR) and co-stimulatory molecules involve specific signaling components and cascades.
Sylvain Latour
doaj  

CD122-targeted interleukin-2 and αPD-L1 treat bladder cancer and melanoma via distinct mechanisms, including CD122-driven natural killer cell maturation

OncoImmunology, 2021
Bladder cancer (BC) and melanoma are amenable to immune checkpoint blockade (ICB) therapy, yet most patients with advanced/metastatic disease do not respond. CD122-targeted interleukin (IL)-2 can improve ICB efficacy, but mechanisms are unclear.
Ryan M Reyes, Chenghao Zhang, Yilun Deng, Niannian Ji, Neelam Mukherjee, Alvaro S Padron, Curtis A Clark, Robert S Svatek, Tyler J Curiel   +8 more
doaj   +1 more source

Elevated monocyte HLA-DR in pediatric secondary hemophagocytic lymphohistiocytosis: a retrospective study

Frontiers in Immunology, 2023
IntroductionHemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition, and its diagnosis may be challenging. In particular, some cases show close similarities to sepsis (fever, organ failure, and high ferritin), but their treatment, while ...
Sylvain Raimbault, Guillaume Monneret, Morgane Gossez, Fabienne Venet, Alexandre Belot, Franck Zekre, Solene Remy, Etienne Javouhey   +7 more
doaj   +1 more source

Lymphocyte‐activation gene‐3, an important immune checkpoint in cancer

Cancer Science, 2016
Immunotherapy has recently become widely used in lung cancer. Many oncologists are focused on cytotoxic T lymphocyte antigen‐4 (CTLA‐4), programmed cell death ligand‐1 (PD‐L1) and programmed cell death‐1 (PD‐1).
Yayi He, C. Rivard, L. Rozeboom, Hui Yu, K. Ellison, Ashley A. Kowalewski, Caicun Zhou, F. Hirsch   +7 more
semanticscholar   +1 more source

Human CD6 Down-Modulation following T-Cell Activation Compromises Lymphocyte Survival and Proliferative Responses

Frontiers in Immunology, 2017
Available evidence indicates that the CD6 lymphocyte surface receptor is involved in T-cell developmental and activation processes, by facilitating cell-to-cell adhesive contacts with antigen-presenting cells and likely modulating T-cell receptor (TCR ...
Esther Carrasco, Cristina Escoda-Ferran, Núria Climent, Cristina Miró-Julià, Inês T. Simões, Mario Martínez-Florensa, Adelaida Sarukhan, Esther Carreras, Francisco Lozano, Francisco Lozano, Francisco Lozano   +10 more
doaj   +1 more source