Results 21 to 30 of about 510,498 (357)

Polysaccharide of Atractylodes macrocephala Koidz (PAMK) Alleviates Cyclophosphamide-induced Immunosuppression in Mice by Upregulating CD28/IP3R/PLCγ-1/AP-1/NFAT Signal Pathway

Frontiers in Pharmacology, 2020
The polysaccharide of Atractylodes macrocephala Koidz (PAMK) is recognized as an immune enhancer, with anti-cancer, anti-tumour, lymphocyte-activating and lymphocytes proliferation-inducing effects.
Xuelian Xiang, Nan Cao, Feiyue Chen, Long Qian, Yifei Wang, Yunmao Huang, Yunbo Tian, Danning Xu, Wanyan Li   +8 more
doaj   +1 more source

Signaling in Lymphocyte Activation [PDF]

Cold Spring Harbor Perspectives in Biology, 2015
The fate of T and B lymphocytes, the key cells that direct the adaptive immune response, is regulated by a diverse network of signal transduction pathways. The T- and B-cell antigen receptors are coupled to intracellular tyrosine kinases and adaptor molecules to control the metabolism of inositol phospholipids and calcium release.
openaire   +4 more sources

Activated T lymphocytes in uveitis. [PDF]

British Journal of Ophthalmology, 1988
Two colour flow cytometry techniques were used to assess the activation stages of peripheral and intraocular T lymphocytes in uveitis. Increased numbers of T lymphocytes bearing the interleukin-2 (IL-2) receptors were found in intraocular fluids or peripheral blood or both of 35/51 patients with uveitis.
J. Deschênes, S. Kaleta, Devron H. Char
openaire   +3 more sources

Immunonutrition before esophagectomy: Impact on immune surveillance mechanisms [PDF]

, 2017
Preoperative oral immunonutrition was demonstrated to improve immune response and to decrease the infection rate in patients with cancer. This study aimed to assess how immunonutrition could influence the immune cell response in the mucosal ...
Agostini, Marco, Alfieri, Rita, Cagol, Matteo, Castagliuolo, Ignazio, Castoro, Carlo, Cavallin, Francesco, Fassan, Matteo, Kotsafti, Andromachi, Nardi, Teresa, Pinto, Eleonora, Rugge, Massimo, Scarpa, Marco, Scarpa, Melania   +12 more
core   +1 more source

Intimate Partner Violence is Associated with Increased CD4+ T-Cell Activation Among HIV-Negative High-Risk Women

Pathogens and Immunity, 2016
Background: Biological pathways mediating the link between intimate partner violence (IPV) and increased HIV risk remain unexplored. We hypothesized that IPV-induced stress negatively affects HIV systemic immune defenses and aimed to evaluate whether IPV
Ameeta Shivdas Kalokhe, Chris C. Ibegbu, Surinder P. Kaur, Rama R. Amara, Mary E. Kelley, Carlos del Rio, Rob Stephenson   +6 more
doaj   +1 more source

Polyunsaturated fatty acid-derived lipid mediators and T cell function [PDF]

, 2014
Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY) .
Marelli-Berg, F, Mauro, C, Nicolaou, A, Urquhart, P   +3 more
core   +2 more sources

Human CD6 Down-Modulation following T-Cell Activation Compromises Lymphocyte Survival and Proliferative Responses

Frontiers in Immunology, 2017
Available evidence indicates that the CD6 lymphocyte surface receptor is involved in T-cell developmental and activation processes, by facilitating cell-to-cell adhesive contacts with antigen-presenting cells and likely modulating T-cell receptor (TCR ...
Esther Carrasco, Cristina Escoda-Ferran, Núria Climent, Cristina Miró-Julià, Inês T. Simões, Mario Martínez-Florensa, Adelaida Sarukhan, Esther Carreras, Francisco Lozano, Francisco Lozano, Francisco Lozano   +10 more
doaj   +1 more source

JC virus-DNA detection is associated with CD8 fffector accumulation in peripheral blood of patients with multiple sclerosis under natalizumab treatment, independently from JC virus serostatus [PDF]

, 2018
Although natalizumab (anti-α4 integrin) represents an effective therapy for relapsing remitting multiple sclerosis (RRMS), it is associated with an increased risk of developing progressive multifocal leukoencephalopathy (PML), caused by the polyomavirus ...
Anzivino, Elena, Ciardi, Maria R., Cortese, Antonio, D’Abramo, Alessandra, Francia, Ada, Frontoni, Marco, Iannetta, Marco, Lichtner, Miriam, Mastroianni, Claudio M., Morreale, Manuela, Oliva, Alessandra, Pietropaolo, Valeria, Pontecorvo, Simona, Prezioso, Carla, Rodio, Donatella Maria, Vullo, Vincenzo, Zingaropoli, Maria A.   +16 more
core   +3 more sources

CD122-targeted interleukin-2 and αPD-L1 treat bladder cancer and melanoma via distinct mechanisms, including CD122-driven natural killer cell maturation

OncoImmunology, 2021
Bladder cancer (BC) and melanoma are amenable to immune checkpoint blockade (ICB) therapy, yet most patients with advanced/metastatic disease do not respond. CD122-targeted interleukin (IL)-2 can improve ICB efficacy, but mechanisms are unclear.
Ryan M Reyes, Chenghao Zhang, Yilun Deng, Niannian Ji, Neelam Mukherjee, Alvaro S Padron, Curtis A Clark, Robert S Svatek, Tyler J Curiel   +8 more
doaj   +1 more source

Effects of combined administration of FK 506 and the purine biosynthesis inhibitors mizoribine or mycophenolic acid on lymphocyte DNA synthesis and T cell activation molecule expression in human mixed lymphocyte cultures [PDF]

, 1993
Our objective was to obtain new information on the in vitro antilymphocytic action of the cytokine synthesis inhibitor FK 506 and the purine biosynthesis inhibitors mycophenolic acid (MPA; the active moiety of RS61443) and mizoribine (MZB) when used ...
A. Zeevi, A.W. Thomson, Amemiya, Armitage, Downward, Eugui, Flanagan, Fung, G.Z. Yao, Gregory, J. Woo, Kiguchi, Kino, Ledbetter, Liu, Morris, Mustelin, O'Shea, Platz, S. Todo, Sawada, Schreiber, Shapiro, Sollinger, Starzl, Suzuki, T.E. Starzl, Thomson, Thomson, Tocci, Turka, Wilson, Woo, Woo, Zeevi   +34 more
core   +1 more source