Results 21 to 30 of about 4,183,330 (355)

Polysaccharide of Atractylodes macrocephala Koidz (PAMK) Alleviates Cyclophosphamide-induced Immunosuppression in Mice by Upregulating CD28/IP3R/PLCγ-1/AP-1/NFAT Signal Pathway

Frontiers in Pharmacology, 2020
The polysaccharide of Atractylodes macrocephala Koidz (PAMK) is recognized as an immune enhancer, with anti-cancer, anti-tumour, lymphocyte-activating and lymphocytes proliferation-inducing effects.
Xuelian Xiang, Nan Cao, Feiyue Chen, Long Qian, Yifei Wang, Yunmao Huang, Yunbo Tian, Danning Xu, Wanyan Li   +8 more
doaj   +1 more source

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

Nature, 2002
Hyung Chun, Lixin Zheng, Jin Wang
exaly   +2 more sources

Increased lymphocyte activation and atherosclerosis in CD47-deficient mice

Scientific Reports, 2019
CD47, also known as integrin-associated protein (IAP), is a transmembrane protein with multiple biological functions including regulation of efferocytosis and leukocyte trafficking.
D. Engelbertsen, Anu Autio, R. Verwilligen, M. Depuydt, G. Newton, S. Rattik, E. Levinsohn, G. Saggu, P. Jarolím, Huan Wang, Francisco E. Velázquez, A. Lichtman, F. Luscinskas   +12 more
semanticscholar   +1 more source

Lymphocyte activation gene 3: a novel therapeutic target in chronic lymphocytic leukemia

Haematologica, 2017
A novel therapeutic approach in cancer, attempting to stimulate host anti-tumor immunity, involves blocking of immune checkpoints. Lymphocyte activation gene 3 (LAG3) is an immune checkpoint receptor expressed on activated/exhausted T cells. When engaged
M. Shapiro, Y. Herishanu, B. Katz, N. Dezorella, Clare Sun, S. Kay, A. Polliack, I. Avivi, A. Wiestner, C. Perry   +9 more
semanticscholar   +1 more source

Intimate Partner Violence is Associated with Increased CD4+ T-Cell Activation Among HIV-Negative High-Risk Women

Pathogens and Immunity, 2016
Background: Biological pathways mediating the link between intimate partner violence (IPV) and increased HIV risk remain unexplored. We hypothesized that IPV-induced stress negatively affects HIV systemic immune defenses and aimed to evaluate whether IPV
Ameeta Shivdas Kalokhe, Chris C. Ibegbu, Surinder P. Kaur, Rama R. Amara, Mary E. Kelley, Carlos del Rio, Rob Stephenson   +6 more
doaj   +1 more source

Human CD6 Down-Modulation following T-Cell Activation Compromises Lymphocyte Survival and Proliferative Responses

Frontiers in Immunology, 2017
Available evidence indicates that the CD6 lymphocyte surface receptor is involved in T-cell developmental and activation processes, by facilitating cell-to-cell adhesive contacts with antigen-presenting cells and likely modulating T-cell receptor (TCR ...
Esther Carrasco, Cristina Escoda-Ferran, Núria Climent, Cristina Miró-Julià, Inês T. Simões, Mario Martínez-Florensa, Adelaida Sarukhan, Esther Carreras, Francisco Lozano, Francisco Lozano, Francisco Lozano   +10 more
doaj   +1 more source

CD122-targeted interleukin-2 and αPD-L1 treat bladder cancer and melanoma via distinct mechanisms, including CD122-driven natural killer cell maturation

OncoImmunology, 2021
Bladder cancer (BC) and melanoma are amenable to immune checkpoint blockade (ICB) therapy, yet most patients with advanced/metastatic disease do not respond. CD122-targeted interleukin (IL)-2 can improve ICB efficacy, but mechanisms are unclear.
Ryan M Reyes, Chenghao Zhang, Yilun Deng, Niannian Ji, Neelam Mukherjee, Alvaro S Padron, Curtis A Clark, Robert S Svatek, Tyler J Curiel   +8 more
doaj   +1 more source

Lymphocyte‐activation gene‐3, an important immune checkpoint in cancer

Cancer Science, 2016
Immunotherapy has recently become widely used in lung cancer. Many oncologists are focused on cytotoxic T lymphocyte antigen‐4 (CTLA‐4), programmed cell death ligand‐1 (PD‐L1) and programmed cell death‐1 (PD‐1).
Yayi He, C. Rivard, L. Rozeboom, Hui Yu, K. Ellison, Ashley A. Kowalewski, Caicun Zhou, F. Hirsch   +7 more
semanticscholar   +1 more source

Regulatory T-lymphocyte subsets in patients with HIV-infection receiving highly active antiretroviral therapy

Бюллетень сибирской медицины, 2019
Background. The reason why HIV-infected patients receiving highly active antiretroviral therapy (HAART) suffer from the increased immune activation remains elusive.
V. A. Chereshnev, E. V. Saidakova, L. B. Korolevskaya, N. G. Shmagel, K. V. Shmagel   +4 more
doaj   +1 more source

Impact of acute exercise on peripheral blood mononuclear cells nutrient sensing and mitochondrial oxidative capacity in healthy young adults

Physiological Reports, 2021
Regular exercise is associated with changes in peripheral blood mononuclear cell (PBMC) proportions that have enhanced effector functions in young and old adults; however, the effects of acute exercise on PBMC nutrient sensors and metabolic function in ...
Bailey Theall, James Stampley, Eunhan Cho, Joshua Granger, Neil M. Johannsen, Brian A. Irving, Guillaume Spielmann   +6 more
doaj   +1 more source