Results 61 to 70 of about 4,129,180 (367)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Non-canonical antigens are the largest fraction of peptides presented by MHC class I in mismatch repair deficient murine colorectal cancer

open access: yesGenome Medicine
Background Immunotherapy based on checkpoint inhibitors is highly effective in mismatch repair deficient (MMRd) colorectal cancer (CRC). These tumors carry a high number of mutations, which are predicted to translate into a wide array of neoepitopes ...
Giuseppe Rospo   +10 more
doaj   +1 more source

Early Diagnosis of Pathogen Infection by Cell-Based Activation Immunoassay

open access: yesCells, 2019
Diagnostic identification of pathogens is usually accomplished by isolation of the pathogen or its substances, and should correlate with the time and site of infection.
Erez Bar-Haim   +13 more
doaj   +1 more source

MicroRNA Activity in B Lymphocytes [PDF]

open access: yes, 2010
Gene expression regulation by miRNAs has been reported to control key aspects of B cell differentiation and function (Chen et al., Science 303:83-86, 2004; Xiao et al., Cell 131:146-159, 2007; O'Carroll et al., Genes Dev. 21:1999-2004, 2007; Koralov et al.
Virginia G. de Yébenes   +1 more
openaire   +3 more sources

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

open access: yesFEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung   +6 more
wiley   +1 more source

Imaging-based histological features are predictive of MET alterations in Non-Small Cell Lung Cancer [PDF]

open access: yesarXiv, 2022
MET is a proto-oncogene whose somatic activation in non-small cell lung cancer leads to increased cell growth and tumor progression. The two major classes of MET alterations are gene amplification and exon 14 deletion, both of which are therapeutic targets and detectable using existing molecular assays.
arxiv  

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

TUMOR-SPECIFIC IMMUNE RESPONSE AFTER PHOTODYNAMIC THERAPY

open access: yesМедицинская иммунология, 2016
Increased incidence of malignancies requires a search for new therapeutic approaches. E.g., photodynamic therapy (PDT) is an effective anti-cancer treatment that involves administration of a photosensitizing dye followed by visible light irradiation of ...
Yu. N. Anokhin, E. V. Abakushina
doaj   +1 more source

Gamma-irradiated influenza virus uniquely induces IFN-I mediated lymphocyte activation independent of the TLR7/MyD88 pathway. [PDF]

open access: yesPLoS ONE, 2011
BACKGROUND: We have shown previously in mice, that infection with live viruses, including influenza/A and Semliki Forest virus (SFV), induces systemic partial activation of lymphocytes, characterized by cell surface expression of CD69 and CD86, but not ...
Yoichi Furuya   +8 more
doaj   +1 more source

Macroscopic limit of a kinetic model describing the switch in T cell migration modes via binary interactions [PDF]

open access: yesarXiv, 2020
Experimental results on the immune response to cancer indicate that activation of cytotoxic T lymphocytes (CTLs) through interactions with dendritic cells (DCs) can trigger a change in CTL migration patterns. In particular, while CTLs in the pre-activation state move in a non-local search pattern, the search pattern of activated CTLs is more localised.
arxiv  

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