Results 41 to 50 of about 311,006 (351)

ASSESSMENT OF STROMAL AND INTRA-EPITHELIAL TUMOR INFILTRATING LYMPHOCYTES IN COLORECTAL CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY

Pakistan Armed Forces Medical Journal, 2021
Objective: To conduct a morphological evaluation quantitatively of two types of tumor-infiltrating lymphocyte populations, including those located in the stroma and intraepithelial cancer structures, in patients with colorectal cancer.
Amna Ameer, Farhan Akhtar, Hafeez Ud Din, Rabia Ahmed   +3 more
doaj   +1 more source

Immunological backbone of uveal melanoma: is there a rationale for immunotherapy? [PDF]

, 2019
No standard treatment has been established for metastatic uveal melanoma (mUM). Immunotherapy is commonly used for this disease even though UM has not been included in phase III clinical trials with checkpoint inhibitors.
Alessandra Cassano, Apte, Bill, Blom, Brigida Anna Maiorano, De Vries, Durie, Emilio Bria, Ericsson, Ernesto Rossi, Giampaolo Tortora, Gianluigi Petrone, Giovanni Schinzari, Guido Rindi, Ilaria Grazia Zizzari, Lagouros, Makitie, Maria Antonietta Blasi, Maria Grazia Sammarco, Marianna Nuti, Monica Maria Pagliara, Shaw, Sohn, Vincenzo Fiorentino, Whelchel   +24 more
core   +1 more source

DIMEimmune: Robust estimation of infiltrating lymphocytes in CNS tumors from DNA methylation profiles

OncoImmunology, 2021
The interaction of CNS tumors with infiltrating lymphocytes plays an important role in their initiation and progression and might be related to therapeutic responses.
Sepehr Safaei, Malte Mohme, Judith Niesen, Ulrich Schüller, Michael Bockmayr   +4 more
doaj   +1 more source

Deep generative selection models of T and B cell receptor repertoires with soNNia [PDF]

, 2020
Subclasses of lymphocytes carry different functional roles to work together to produce an immune response and lasting immunity. Additionally to these functional roles, T and B-cell lymphocytes rely on the diversity of their receptor chains to recognize different pathogens.
arxiv   +1 more source

Frequency over function : raised levels of CD127low/- regulatory T cells in the tumour microenvironment compared with the periphery of head and neck cancer patients [PDF]

, 2014
Objective: Regulatory T cells (Tregs) are known to infiltrate the tumour microenvironment of many cancers, including head and neck malignancies, and are thought to contribute to the host's impaired anti-tumour immune response.
Drennan, Samantha, Green, Victoria L., Greenman, John, Stafford, Nicholas D.   +3 more
core   +1 more source

CTL Attenuation Regulated by PS1 in Cancer-Associated Fibroblast

Frontiers in Immunology, 2020
Objective: Cancer-associated fibroblasts (CAFs) were associated with tumor progression in the tumor microenvironment (TME). However, their immunosuppressive roles in protecting cancer cells from the attack by cytotoxic T lymphocytes (CTLs) are not fully ...
Hongyu Zhang, Rong Jiang, Jinhua Zhou, Juan Wang, Yuejuan Xu, He Zhang, Yanzheng Gu, Yanzheng Gu, Yanzheng Gu, Fengqing Fu, Fengqing Fu, Fengqing Fu, Yu Shen, Yu Shen, Yu Shen, Guangbo Zhang, Guangbo Zhang, Guangbo Zhang, Lanlan Feng, Xueguang Zhang, Xueguang Zhang, Xueguang Zhang, Youguo Chen, Fangrong Shen   +23 more
doaj   +1 more source

Tumor-infiltrating B cells and T cells correlate with postoperative prognosis in triple-negative carcinoma of the breast

BMC Cancer, 2021
Background In this study, we investigated CD20+ TILs in triple-negative breast cancer (TNBC) and their relationship with T lymphocyte subsets (CD4+, CD8+, CD25+, and FOXP3+), including their combined prognostic value using an immunohistochemical staining
Hajime Kuroda, Tsengelmaa Jamiyan, Rin Yamaguchi, Akinari Kakumoto, Akihito Abe, Oi Harada, Atsuko Masunaga   +6 more
doaj   +1 more source

PathRTM: Real-time prediction of KI-67 and tumor-infiltrated lymphocytes [PDF]

arXiv, 2023
In this paper, we introduce PathRTM, a novel deep neural network detector based on RTMDet, for automated KI-67 proliferation and tumor-infiltrated lymphocyte estimation. KI-67 proliferation and tumor-infiltrated lymphocyte estimation play a crucial role in cancer diagnosis and treatment.
arxiv  

Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

npj Breast Cancer, 2020
Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment.
Z. Kos, Elvire Roblin, Rim S. Kim, S. Michiels, B. Gallas, Weijie Chen, K. K. van de Vijver, S. Goel, S. Adams, S. Demaria, G. Viale, T. Nielsen, S. Badve, W. Symmans, C. Sotiriou, D. Rimm, S. Hewitt, C. Denkert, S. Loibl, S. Luen, J. Bartlett, P. Savas, G. Pruneri, D. Dillon, M. Cheang, A. Tutt, Jacqueline A. Hall, M. Kok, H. Horlings, A. Madabhushi, J. A. van der Laak, F. Ciompi, A. Laenkholm, E. Bellolio, T. Gruosso, S. Fox, J. Araya, G. Floris, J. Hudeček, L. Voorwerk, Andrew H. Beck, J. Kerner, D. Larsimont, S. Declercq, G. G. Van den Eynden, L. Pusztai, A. Ehinger, Wentao Yang, K. AbdulJabbar, Yinyin Yuan, Rajendra Singh, C. Hiley, Maise Al Bakir, A. Lazar, S. Naber, S. Wienert, Miluska Castillo, G. Curigliano, M. Dieci, F. André, C. Swanton, J. Reis-Filho, J. Sparano, E. Balslev, I. Chen, E. Stovgaard, K. Pogue-Geile, K. Blenman, F. Penault-Llorca, S. Schnitt, S. Lakhani, A. Vincent-Salomon, F. Rojo, J. Braybrooke, M. Hanna, M. T. Soler-Monsó, D. Bethmann, C. Castañeda, K. Willard-Gallo, Ashish Sharma, H. Lien, S. Fineberg, J. Thagaard, L. Comerma, Paula I. Gonzalez-Ericsson, E. Brogi, S. Loi, J. Saltz, Frederick Klaushen, L. Cooper, M. Amgad, D. Moore, R. Salgado, A. A. I. A. A. A. A. A. A. M. A. Hyytiäinen Hida Thompson Lefevre Gown Lo Sapino Mo, Aini Hyytiäinen, A. Hida, A. Thompson, A. Lefevre, A. Gown, Amy A. Lo, A. Sapino, Andre Moreira, A. Richardson, A. Vingiani, A. Bellizzi, Á. Guerrero, A. Grigoriadis, A. Garrido-Castro, A. Cimino-Mathews, A. Srinivasan, B. Ács, Baljit Singh, B. Calhoun, Benjamin Haibe-Kans, B. Solomon, B. Thapa, B. Nelson, Carmen Ballesteroes-Merino, C. Criscitiello, Carolien Boeckx, C. Colpaert, C. Quinn, C. Chennubhotla, C. Solinas, D. Drubay, D. Sabanathan, D. Peeters, D. Zardavas, D. Höflmayer, Douglas B. Johnson, E. Thompson, E. Perez, E. Elgabry, E. Blackley, Emily S. Reisenbichler, E. Chmielik, F. Gaire, F. Lu, Farid Azmoudeh-Ardalan, F. Peale, F. Hirsch, Gabriela Acosta-Haab, G. Farshid, G. Broeckx, H. Koeppen, H. R. Haynes, H. McArthur, H. Joensuu, H. Olofsson, I. Cree, I. Nederlof, I. Frahm, I. Brčić, Jack Junjie Chan, James Ziai, J. Brock, Jelle Weseling, J. Giltnane, J. Lemonnier, J. Zha, J. Ribeiro, J. Lennerz, J. Carter, J. Hartman, J. Hainfellner, J. Le Quesne, J. Juco, J. G. van den Berg, Joselyn Sanchez, J. Cucherousset, J. Adam, J. Balko, K. Saeger, K. Siziopikou, K. Sikorska, K. Weber, K. Steele, K. Emancipator, K. El Bairi, K. Allison, Konstanty Korski, L. Buisseret, Leming Shi, L. Kooreman, L. Molinero, M. V. Estrada, M. van Seijen, M. Lacroix-Triki, Manu Sebastian, M. Balancin, M. Mathieu, M. J. van de Vijver, M. Rebelatto, M. Piccart, M. Goetz, M. Preusser, M. Khojasteh, M. Sanders, M. Regan, Michael Barnes, M. Christie, M. Misialek, M. Ignatiadis, M. de Maaker, M. V. van Bockstal, N. Harbeck, N. Tung, Nele Laudus, N. Sirtaine, N. Burchardi, N. Ternès, N. Radosevic-Robin, O. Gluz, O. Grimm, P. Nuciforo, P. Jank, Pawan Kirtani, P. Watson, Peter Jelinic, P. Francis, P. Russell, R. Pierce, R. Hills, R. Leon-Ferre, R. De Wind, R. Shui, S. Leung, S. Tabbarah, Sandra C. Souza, S. O'toole, S. Swain, S. Dudgeon, S. Willis, S. Ely, S. Bedri, Sheeba Irshad, Shiwei Liu, S. Hendry, S. Bianchi, S. Bragança, S. Paik, Sua Luz, T. Gevaert, Timothy d’Alfons, T. John, Tomohagu Sugie, U. Kurkure, V. Bossuyt, V. Manem, Vincente Peg Cámaea, W. Tong, W. Tran, Yihong Wang, Y. Allory, Z. Husain, Z. Bago-Horvath   +255 more
semanticscholar   +1 more source

Tumor-infiltrating lymphocytes and breast cancer: Beyond the prognostic and predictive utility

Tumor Biology, 2017
The importance of the immune system as a potent anti-tumor defense has been consolidated in recent times, and novel immune-related therapies are today demonstrating a strong clinical benefit in the setting of several solid neoplasms.
Andrea Ravelli, Giandomenico Roviello, Daniele Cretella, Andrea Cavazzoni, Alessandra Biondi, Maria Rosa Cappelletti, Laura Zanotti, Giuseppina Ferrero, Marco Ungari, Fabrizio Zanconati, Alberto Bottini, Roberta Alfieri, Pier Giorgio Petronini, Daniele Generali   +13 more
doaj   +1 more source