Results 31 to 40 of about 17,417 (215)

Quantitative and Qualitative Analysis of Humoral Immunity Reveals Continued and Personalized Evolution in Chronic Viral Infection

Cell Reports, 2020
Summary: Control of established chronic lymphocytic choriomeningitis virus (LCMV) infection requires the production of neutralizing antibodies, but it remains unknown how the ensemble of antibodies evolves during ongoing infection.
Nike Julia Kräutler, Alexander Yermanos, Alessandro Pedrioli, Suzanne P.M. Welten, Dominique Lorgé, Ute Greczmiel, Ilka Bartsch, Jörg Scheuermann, Jonathan D. Kiefer, Klaus Eyer, Ulrike Menzel, Victor Greiff, Dario Neri, Tanja Stadler, Sai T. Reddy, Annette Oxenius   +15 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Lymphocytic Choriomeningitis Virus–associated Meningitis, Southern Spain

Emerging Infectious Diseases, 2012
Lymphocytic choriomeningitis virus (LCMV) was detected in 2 patients with acute meningitis in southern Spain within a 3-year period. Although the prevalence of LCMV infection was low (2 [1.3%] of 159 meningitis patients), it represents 2.9% of all ...
Mercedes Pérez-Ruiz, José-María Navarro-Marí, María-Paz Sánchez-Seco, María-Isabel Gegúndez, Gustavo Palacios, Nazir Savji, W. Ian Lipkin, Giovanni Fedele, Fernando de Ory-Manchón   +8 more
doaj   +1 more source

Immunometabolic and Spatiotemporal Control of Tissue‐Resident Memory T Cell Biology

Barrier Immunity, EarlyView.
Tissue‐resident memory T (TRM) cells in barrier tissues provide a frontline defense against invading pathogens. Immune (Signals 1–3) and nutrient (Signal 4) cues play an integral role in directing TRM formation and heterogeneity. The spatial and temporal organization of these signals establishes durable TRM cells across tissues, enabling diverse ...
Jana L. Raynor, Hongbo Chi
wiley   +1 more source

Tradeoffs between brain and digestive tissues across elevations in Typhlomys daloushanensis: evidence for sexual dimorphism

Wildlife Biology, EarlyView.
To cope with highly stochastic and/or heterogeneous environmental conditions, animals must balance energy resource allocation across physiological processes. The digestive tract and brain exhibit structural variations under strong developmental and selective pressures that vary across environmental gradients both between and within species.
Yimei Yan, Bangqing Chen, Jifa Cui, Chris Newman, Boyu Lei, Nan Wu, Jinwei Wu, Jin Zhao, Christina D. Buesching, Youbing Zhou   +9 more
wiley   +1 more source

CEACAM1 promotes CD8+ T cell responses and improves control of a chronic viral infection

Nature Communications, 2018
Chronic viral infections are frequently associated with the dysfunction of CD8+ T cells which includes loss of function and results in CD8+ T cell exhaustion.
Vishal Khairnar, Vikas Duhan, Ashwini M. Patil, Fan Zhou, Hilal Bhat, Christine Thoens, Piyush Sharma, Tom Adomati, Sarah-Kim Friendrich, Judith Bezgovsek, Janine D. Dreesen, Gunther Wennemuth, Astrid M. Westendorf, Gennadiy Zelinskyy, Ulf Dittmer, Cornelia Hardt, Jörg Timm, Joachim R. Göthert, Philipp A. Lang, Bernhard B. Singer, Karl S. Lang   +20 more
doaj   +1 more source

Independent Lineage of Lymphocytic Choriomeningitis Virus in Wood Mice (Apodemus sylvaticus), Spain

Emerging Infectious Diseases, 2009
To clarify the presence of lymphocytic choriomeningitis virus (LCMV) in Spain, we examined blood and tissue specimens from 866 small mammals. LCMV RNA was detected in 3 of 694 wood mice (Apodemus sylvaticus).
Juan Ledesma, Cesare Giovanni Fedele, Francisco Carro, Lourdes Lledó, María Paz Sánchez-Seco, Antonio Tenorio, Ramón Casimiro Soriguer, José Vicente Saz, Gerardo Domínguez, María Flora Rosas, Jesús Félix Barandika, María Isabel Gegúndez   +11 more
doaj   +1 more source

Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses

Cell Reports, 2020
Summary: Persistent viral infections subvert key elements of adaptive immunity. To compare germinal center (GC) B cell responses in chronic and acute lymphocytic choriomeningitis virus infection, we exploit activation-induced deaminase (AID) fate ...
Bénédict Fallet, Yi Hao, Marianna Florova, Karen Cornille, Alba Verge de los Aires, Giulia Girelli Zubani, Yusuf I. Ertuna, Victor Greiff, Ulrike Menzel, Karim Hammad, Doron Merkler, Sai T. Reddy, Jean-Claude Weill, Claude-Agnès Reynaud, Daniel D. Pinschewer   +14 more
doaj   +1 more source

Infection control in the brain and the eye

Acta Ophthalmologica, EarlyView.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

Lymphocytic Choriomeningitis—Emerging Trends of a Neglected Virus: A Narrative Review

Tropical Medicine and Infectious Disease, 2021
Lymphocytic choriomeningitis virus (LCMV) is a neglected rodent-borne zoonotic virus distributed worldwide. Since serologic assays are limited to several laboratories, the disease has been underreported, often making it difficult to determine incidence ...
Tatjana Vilibic-Cavlek, Vladimir Savic, Thomas Ferenc, Anna Mrzljak, Ljubo Barbic, Maja Bogdanic, Vladimir Stevanovic, Irena Tabain, Ivana Ferencak, Snjezana Zidovec-Lepej   +9 more
doaj   +1 more source