Results 41 to 50 of about 17,417 (215)

Immune Exhaustion in Chronic Infection and Cancer: Signaling Pathways and Therapeutic Interventions

MedComm, Volume 7, Issue 3, March 2026.
Immune exhaustion is a well‐established hallmark of both cancer and chronic infection. This review proposes a novel “infection–exhaustion–tumor axis” framework, wherein chronic pathogens (e.g., oncogenic viruses) evade immune surveillance by hijacking inflammatory signaling to drive immune cell exhaustion, thereby creating immunosuppressive niches ...
Yali Song, Yazhi Mo, Si Chen, Yuemei Chen, Chunying Zhang, Shanying Deng, Juan Liao, Yi He, Wei Wang, Weidong Zheng, Tingting Zeng   +10 more
wiley   +1 more source

Лимфоцитен хориоменингит – клиничен случай

Българска неврология, 2023
Lymphocytic choriomeningitis virus е един от причинителите на неврологични заболявания при хора. Заразяването с вируса се осъществява посредством контакт с миши екскременти.
Sashka Zhelyazkova, A. Taneva, S. Cherninkova, I. Tournev   +3 more
doaj  

Society for Maternal‐Fetal Medicine Consult Series #75: Evaluation and management of non‐immune hydrops fetalis

Pregnancy, Volume 2, Issue 2, March 2026.
Abstract Non‐immune hydrops fetalis (NIHF) can result from a multitude of underlying causes, such as fetal genetic diseases, congenital anomalies, infections, fetal arrhythmias, placental tumors, monochorionic twin complications, and other disorders.
Society for Maternal‐Fetal Medicine (SMFM), Teresa. N. Sparks, Mary. E. Norton, SMFM Publications Committee   +3 more
wiley   +1 more source

Distribution and Infestation of Gamasid Mite Androlaelaps fahrenholzi (Haemolaelaps glasgowi) on Small Mammals Across Five Provincial Regions of Southwest China

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
Androlaelaps fahrenhoizi, a potential vector of zoonotic diseases, is widely distributed in southwest China, predominantly infesting A. agrarius mice. The mite infestation is aggregated, and has environmental heterogeneity and age bias of hosts. Abundant A.
Xue‐Jiao Zhu, Ya‐Nan Li, Xian‐Guo Guo, Tian‐Guang Ren   +3 more
wiley   +1 more source

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, Volume 183, Issue 6, Page 1250-1270, March 2026.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

Identification of potential novel hosts and the risk of infection with lymphocytic choriomeningitis virus in humans in Gabon, Central Africa

International Journal of Infectious Diseases, 2021
Objectives: Lymphocytic choriomeningitis virus (LCMV), a human pathogenic arenavirus, is distributed worldwide. However, no human cases have been reported in Africa.
Yuri Ushijima, Haruka Abe, Takehiro Ozeki, Georgelin N. Ondo, Marien J.V.M. Mbadinga, Rodrigue Bikangui, Chimène Nze-Nkogue, Etienne F. Akomo-Okoue, Ghislain W.E. Ella, Lilian B.M. Koumba, Branly C.B.B. Nso, Rodrigue Mintsa-Nguema, Patrice Makouloutou-Nzassi, Boris K. Makanga, Fred L.M. Nguelet, Vahid R. Zadeh, Shuzo Urata, Armel V.N. Mbouna, Marguerite Massinga-Loembe, Selidji T. Agnandji, Bertrand Lell, Jiro Yasuda   +21 more
doaj   +1 more source

CD27 and ICOS as Targets of PD‐1/PD‐L1 Signaling to Regulate Resident Memory CD8+ T‐Cell‐Mediated Pulmonary Protection and Pathology

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Here it is revealed that the costimulatory receptors CD27 and ICOS are essential for the long‐term maintenance of PD‐1high CD8+ TRM cells following influenza infection. PD‐L1 blockade enhances the proliferation and activation of these cells through Nur77 activation downstream of the CD27/ICOS signaling axis, thereby boosting host immunity against ...
Yuanyuan Chen, Zhenzhen Wang, Liqiang Song, Qianqian Chen, Hang Zhang, Tao Pan, Jianli Pan, Sheng Zhao, Ting Shang, Hong'en Xu, Xing Lv, Jing Li, Fei Kang, Yongzhan Nie, Feng Zhao, Lei Shi, Zheng Wang   +16 more
wiley   +1 more source

Overcoming challenges in CAR‐T therapy for malignancies: Mechanisms and strategies

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
Chimeric antigen receptor T (CAR‐T) cell therapy faces three major challenges: tumour‐intrinsic resistance mechanisms, limitations in CAR‐T cell efficacy and immunosuppressive tumour microenvironment (TME) effects. Emerging strategies address these hurdles through precision targeting enhancement, optimised CAR‐T cell persistence/functionality and TME ...
Yushan Huang, Jun Long, Changpeng Yang, Wang Lu, Husheng Mei, Wenbin Qian, Jing Yang, Aibin Liang   +7 more
wiley   +1 more source

Single‐cell analysis reveals cytotoxic and memory CD8+ T cells associated with prolonged survival in relapsed/refractory leukaemia patients after haplo+cord haematopoietic stem cell transplantation

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
1. Haplo+cord HSCT yields superior survival compared with single cord HSCT in patients with R/R leukaemia. 2. Single‐cell RNA‐seq revealed a functionally critical CD8⁺ T cell population, with cytotoxic and memory phenotypes, which expands after haplo+cord HSCT and tracks with prolonged survival. 3. Multi‐omics profiling at single‐cell resolution showed
Hua Li, Zheyang Zhang, Ming Zhu, Xiaofan Li, Jinxian Dai, Ping Chen, Fei Chen, Xianling Chen, Yiding Yang, Xiaohong Yuan, Ronghan Tang, Zhijuan Zhu, Hongli Lin, Ting Lin, Mengsha Tong, Tao Chen, Yuanzhong Chen, Jialiang Huang, Nainong Li   +18 more
wiley   +1 more source

Solid Organ Transplant–associated Lymphocytic Choriomeningitis, United States, 2011

Emerging Infectious Diseases, 2012
Three clusters of organ transplant–associated lymphocytic choriomeningitis virus (LCMV) transmissions have been identified in the United States; 9 of 10 recipients died. In February 2011, we identified a fourth cluster of organ transplant–associated LCMV
Adam MacNeil, Ute Ströher, Eileen Farnon, Shelley Campbell, Deborah Cannon, Christopher D. Paddock, Clifton P. Drew, Matthew Kuehnert, Barbara Knust, Robert Gruenenfelder, Sherif R. Zaki, Pierre E. Rollin, Stuart T. Nichol   +12 more
doaj   +1 more source