Comprehensive methylome map of lineage commitment from haematopoietic progenitors. [PDF]
Epigenetic modifications must underlie lineage-specific differentiation as terminally differentiated cells express tissue-specific genes, but their DNA sequence is unchanged.
Aryee, Martin J+17 more
core +5 more sources
In vitro transformation of lymphoid cells by Abelson murine leukemia virus [PDF]
Cell cultures prepared from fetal murine liver were infected by Abelson murine leukemia virus. After about 2 weeks, proliferating cells of lymphoid morphology appeared in some of the cultures.
Baltimore, David+2 more
core +2 more sources
Lymphoid microenvironments and innate lymphoid cells in the gut
Gut-associated lymphoid tissue (GALT) is a sensor region for luminal content and plays an important role in lymphoid maturation, activation and differentiation. It comprises isolated and aggregated lymphoid follicles, cryptopatches (CPs) and tertiary lymphoid tissue. Innate lymphoid cells (ILCs) play a central role within GALT.
Pearson, C, Uhlig, H, Powrie, F
openaire +5 more sources
Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin. [PDF]
Expression of the cell-surface antigen CD10 has long been used to define the lymphoid commitment of human cells. Here we report a unique lymphoid-primed population in human bone marrow that was generated from hematopoietic stem cells (HSCs) before onset ...
Crooks, Gay M+7 more
core +1 more source
Occupation and lymphoid neoplasms [PDF]
The relationship between occupation and exposure to a number of occupational agents and lymphoid neoplasms was investigated in a case-control study of 69 cases of Hodgkin's disease, 153 non-Hodgkin's lymphomas, 110 multiple myelomas and 396 controls admitted for acute diseases to a network of teaching and general hospitals in the greater Milan area ...
C. La Vecchia+3 more
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HiJAKing innate lymphoid cells? [PDF]
The family of innate lymphoid cells (ILCs) consists of a heterogeneous group of cytokine-producing cells that have features in common with adaptive T helper (Th) cells.
Gadina, Massimo+2 more
core +1 more source
Production of recombinant antibodies in lymphoid and non‐lymphoid cells [PDF]
A recombinant tandem of ‘chimeric’ mouse/human immunoglobulin (Ig) genes was constructed and inserted into plasmid pGEM 1 under the control of the T7 bacteriophage RNA polymerase promoter. Lymphoid (Sp2/0) and non‐lymphoid (CHO) cell lines used for transfection contained in their genomes a semisynthetic gene of T7 RNA polymerase and steadily expressed ...
Boris V. Radko+3 more
openaire +3 more sources
Oestrogen, an evolutionary conserved regulator of T cell differentiation and immune tolerance in jawed vertebrates? [PDF]
In teleosts, as in mammals, the immune system is tightly regulated by sexual steroid hormones, such as oestrogens. We investigated the effects of 17β-oestradiol on the expression of several genes related to T cell development and resulting T cell ...
Duflot, Aurélie+5 more
core +2 more sources
Lymphoid Neogenesis and Tertiary Lymphoid Organs in Transplanted Organs [PDF]
The progressive organization of immune effectors into functional ectopic lymphoid structures, named tertiary lymphoid organs (TLO), has been observed in many conditions in which target antigens fail to be eliminated by the immune system. Not surprisingly, TLO have been recurrently identified in chronically rejected allografts.
Alice Koenig+3 more
openaire +3 more sources
A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus [PDF]
A quantitative Abelson murine leukemia virus (A-MuLV) lymphoid cell transformation assay has been developed using a semisolid agarose culture system. Under these conditions lymphoid cell transformation was shown to vary linearly with the dose of A-MuLV ...
Baltimore, David, Rosenberg, Naomi
core +1 more source