Results 51 to 60 of about 13,416 (164)

Accumulation of Oxidized Low-Density Lipoprotein in Psoriatic Skin and Changes of Plasma Lipid Levels in Psoriatic Patients

Mediators of Inflammation, 2007
Background. Psoriasis is a chronic inflammatory skin disease characterized by an accelerated turnover of epidermal cells and an incomplete differentiation in epidermis with lesion. However, the exact etiology of psoriasis is unknown.
Nilgun Solak Tekin, Ishak Ozel Tekin, Figen Barut, Emine Yilmaz Sipahi   +3 more
doaj   +1 more source

A systematic review of case–control studies of cytokines in blister fluid and skin tissue of patients with Stevens Johnson syndrome and toxic epidermal necrolysis

Australasian Journal of Dermatology, Volume 65, Issue 6, Page 491-504, September 2024.
Abstract Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions characterised by keratinocyte apoptosis, necroptosis and epidermal detachment. Several cytokines and cytotoxic proteins have been shown to be elevated in the blood and skin of SJS/TEN sufferers and biologics such as intravenous immune ...
Thomas Jonathan Stewart, Joshua Farrell, John Walter Frew   +2 more
wiley   +1 more source

Epigenetic modulation of selected immune response genes and altered functions of T lymphocytes and macrophages collectively contribute to autoimmune diabetes protection

BBA Advances, 2021
We have previously demonstrated that weekly treatment of female prediabetic NOD mice with a low dose of the histone deacetylase inhibitor Trichostatin A (TSA) bestowed long-lasting, irreversible protection against autoimmune diabetes. Herein we show that
Arathi Jayaraman, Maria Arianas, Sundararajan Jayaraman   +2 more
doaj  

Natural killer cells in cancer immunotherapy

MedComm, Volume 5, Issue 7, July 2024.
NK cells have cytotoxic functions against tumor cells especially through NKG2D receptor. This article reviews the mechanisms how tumors escape NK‐mediated killing and therapeutic strategies with NK cells and especially MICA/B–NKG2D axis. Finally, the recent innovative CAR‐NK/NKG2D CAR‐T and MICA/B vaccines in tumor were summarized.
DanRu Wang, LingYun Dou, LiHao Sui, Yiquan Xue, Sheng Xu   +4 more
wiley   +1 more source

V-region-related and -unrelated immunosupression accompanying infections

Memorias do Instituto Oswaldo Cruz, 1992
This paper discusses current evidence for the relationship between polyclonal lymphocyte activation, specific immunossupression with decreased resistance, and autoimmune pathology, that are all often found associated with infections by a variety of virus,
Mario Arala-Chaves, M. Regina D'Imperio Lima, Antonio Coutinho, Claudia Penna-Rossi, Paola Minoprio   +4 more
doaj   +1 more source

The effects of inhaled corticosteroids on healthy airways

Allergy, Volume 79, Issue 7, Page 1831-1843, July 2024.
4‐week ICS suppressed a broad spectrum of genes associated with adaptive T and B cell, and innate immunity, likely explaining the association between ICS use and pneumonia. Tonic T2 signalling in healthy airways was exquisitively sensitive to ICS, while an IL‐17‐dependent gene signature and CEACAM family members were not upregulated by 4‐week ICS ...
Emanuele Marchi, Timothy S. C. Hinks, Matthew Richardson, Latifa Khalfaoui, Fiona A. Symon, Poojitha Rajasekar, Rachel Clifford, Beverley Hargadon, Cary D. Austin, Julia L. MacIsaac, Michael S. Kobor, Salman Siddiqui, Jordan S. Mar, Joseph R. Arron, David F. Choy, Peter Bradding   +15 more
wiley   +1 more source

Crosstalk between T lymphocyte and extracellular matrix in tumor microenvironment

Frontiers in Immunology
The extracellular matrix (ECM) is a complex three-dimensional structure composed of proteins, glycans, and proteoglycans, constituting a critical component of the tumor microenvironment.
Die Lv, Yujie Fei, Hongli Chen, Junfeng Wang, Wenwen Han, Bomiao Cui, Yun Feng, Ping Zhang, Jiao Chen   +8 more
doaj   +1 more source

Pré-eclâmpsia: estresse oxidativo, inflamação e disfunção endotelial Preeclampsia: oxidative stress, inflammation and endothelial dysfunction

Revista Brasileira de Ginecologia e Obstetrícia, 2010
Pré-eclâmpsia é uma síndrome sistêmica caracterizada por intenso estado inflamatório e antiangiogênico. A fisiopatologia da pré-clâmpsia envolve alterações no processo de invasão trofoblástica, com consequente inadequado suprimento sanguíneo uterino e ...
Leandro Gustavo de Oliveira, Ananth Karumanchi, Nelson Sass   +2 more
doaj   +1 more source

From supernatants to cytokines: a personal view on the early history of IL-1, IL-1Ra, TNF and its inhibitor in rheumatology

Arthritis Research & Therapy, 2018
Long-term cell cultures developed early in the twentieth century allowed identification in their supernatants of biological mediators subsequently defined as migration factors, interferons, lymphokines, monokines, cytokines and interleukins.
Jean-Michel Dayer
doaj   +1 more source

<i>ICOS</i> gene polymorphisms in B-cell chronic lymphocytic leukemia in the Polish population

Folia Histochemica et Cytobiologica, 2011
There is strong evidence that altered immunological function entails an increased risk of B-cell chronic lymphocytic leukemia (B-CLL). The main mechanism of an anti-tumor response depends on T-cell activation.
Irena Frydecka, Kazimierz Kuliczkowski, Dariusz Woszczyk, Marek Kielbinski, Dariusz Wolowiec, Anna Tomkiewicz, Anna Jedynak, Lidia Karabon   +7 more
doaj   +1 more source