Results 131 to 140 of about 141,580 (256)

Fixed‐Duration Subcutaneous Mosunetuzumab in Relapsed/Refractory Follicular Lymphoma: Pivotal Phase 2 Primary Analysis

American Journal of Hematology, Volume 101, Issue 5, Page 986-997, May 2026.
ABSTRACT Mosunetuzumab is approved as an intravenous (IV) formulation for relapsed/refractory (R/R) follicular lymphoma (FL) after ≥ 2 prior therapies. A subcutaneous (SC) formulation, aiming to improve patient safety and convenience, has been developed.
Nancy L. Bartlett, Laurie H. Sehn, Sarit Assouline, Pratyush Giri, John Kuruvilla, Stephen J. Schuster, Sung‐Soo Yoon, Keith Fay, Georg Hess, Martin Dreyling, Norma C. Gutierrez, Eva Cybulski, Fidelis Sabalvaro, Elicia Penuel, Vanda Teodoro, Samuel Tracy, Denison Kuruvilla, Joseph Chen, Volker Wiebking, Michael C. Wei, L. Elizabeth Budde   +20 more
wiley   +1 more source

Mismatch repair genes in Lynch syndrome: a review

São Paulo Medical Journal
Lynch syndrome represents 1-7% of all cases of colorectal cancer and is an autosomal-dominant inherited cancer predisposition syndrome caused by germline mutations in deoxyribonucleic acid (DNA) mismatch repair genes.
Felipe Cavalcanti Carneiro da Silva, Mev Dominguez Valentin, Fábio de Oliveira Ferreira, Dirce Maria Carraro, Benedito Mauro Rossi   +4 more
doaj   +1 more source

Integrated Molecular Profiling Improves Subtype Classification and Reveals Inherited Susceptibility in Medulloblastoma: Insights From a Real‐World Cohort

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Medulloblastoma (MB) is a heterogeneous pediatric brain tumor characterized by distinct molecular subtypes. Although genomics and transcriptomics have improved subtype classification and informed targeted therapies, the clinical utility of integrated molecular profiling in real‐world settings remains incompletely defined. Methods We
Jiwei Song, Tiantian Han, Siqi Chen, Dongsheng Chen, Ziying Liu   +4 more
wiley   +1 more source

Efficacy of Fertility‐Sparing Treatment With Progestin Is Associated With Different Molecular Classification in Endometrial Carcinoma and Atypical Endometrial Hyperplasia

Cancer Medicine, Volume 15, Issue 5, May 2026.
Molecular profiles and outcomes of CR rate in 74 cases. ABSTRACT Objective To investigate the impact of various molecular characteristics on the outcomes of fertility‐preserving therapy in patients with endometrial cancer (EC) and atypical endometrial hyperplasia (AEH).
Xue‐Qian Qian, Hao‐Hui Fu, Xiao‐Yun Wan, Dong‐Xiao Hu, Yuan‐Ming Shen   +4 more
wiley   +1 more source

NGS Panels applied to Hereditary Cancer Syndromes [PDF]

, 2019
Cancer is among the leading causes of morbidity and mortality worldwide (Okur et al, 2017). Germline pathogenic variants for monogenic, highly penetrant cancer susceptibility genes are observed in 5%–10% of all cancers (Lu et al, 2014).
Gonçalves, João, Rodrigues, Pedro, Silva, Catarina, Theisen, Patrícia, Vieira, Luís   +4 more
core  

A pleiotropic “stretch” phenotype is associated with metaxylem vessel element length, axial hydraulic conductance, root elongation, water utilization, and drought adaptation in maize

Crop Science, Volume 66, Issue 3, May/June 2026.
Abstract We tested the hypothesis that metaxylem phenotypes influence drought adaptation in maize (Zea mays L.) through in silico modeling and empirical studies under water deficit in controlled environments and in the field. Substantial genotypic variation for metaxylem vessel element length (MVEL) was observed. Longer MVEL was correlated with reduced
Christopher F. Strock, Cody L. DePew, Jagdeep S. Sidhu, Tianyu Xu, Jonathan P. Lynch   +4 more
wiley   +1 more source

Neurotransmitter-gated ion channels at fast chemical synapses: from structure to pathology [PDF]

, 2005
Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur.
Bouzat, Cecilia Beatriz
core  

Eurocentric Bias in Dysmorphology and Medical Genetics Education

American Journal of Medical Genetics Part A, Volume 200, Issue 6, June 2026.
D' Arcy B. Prendergast, Emma Sullivan, Michael P. Mackley, Hanna Faghfoury   +3 more
wiley   +1 more source

Secondary Colonic Adenocarcinoma After Continent Cutaneous Urinary Diversion a.m. Lundiana—An Aggressive Disease Entity With High Risk of Locally Advanced Disease and Metastases

IJU Case Reports, Volume 9, Issue 3, May 2026.
ABSTRACT Introduction We herein report two patients developing secondary adenocarcinomas arising in colonic segments used for urinary diversion a.m. Lundiana in a population‐based series 16 and 27 years after cystectomy, respectively. Case Presentation Following initial partial resection of the pouch, both patients experienced local recurrence; one ...
Fredrik Liedberg, Mats Bläckberg, Johannes Bobjer   +2 more
wiley   +1 more source

Long‐term clinical and MRI outcomes of a polyurethane meniscal scaffold implantation for the treatment of partial meniscal deficiency: A minimum 10‐year follow‐up study

Knee Surgery, Sports Traumatology, Arthroscopy, Volume 34, Issue 5, Page 1597-1605, May 2026.
Abstract Purpose To assess the clinical and magnetic resonance imaging (MRI) results after implantation of a polyurethane scaffold for chronic segmental meniscus deficiency following partial meniscectomy in a long‐term follow‐up. Study Design Level IV, retrospective case series. Methods Thirty‐two knees received arthroscopic implantation of an Actifit®
Vasileios S. Akrivos, George A. Komnos, Bela Ujvari, Artemis Hante, Eleftheria Adaktylidou, Theofilos Karachalios, Michael Hantes   +6 more
wiley   +1 more source