Results 131 to 140 of about 37,501 (261)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Immunoprofiles of colorectal cancer from Lynch syndrome

, 2019
Colorectal cancers associated with Lynch syndrome are characterized by defective mismatch repair, microsatellite instability, high mutation rates, and a highly immunogenic environment.
Andersen, Ove, Nilbert, Mef, Kallemose, Thomas,, Jönsson, Mats, Andersen, Ove,, Andersen, Mads Hald,, Andersen, Mads Hald, Therkildsen, Christina, Jönsson, Göran, Langkilde, Anne, Jönsson, Göran,, Langkilde, Anne,, Svane, Inge Marie, Svane, Inge Marie,, Therkildsen, Christina,, Lund University., Kallemose, Thomas, Jönsson, Mats,, Walkowska, Joanna, Nilbert, Mef,, Walkowska, Joanna,   +20 more
core   +1 more source

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source

Two decades of resurrection studies: What have we learned about contemporary evolution of plant species?

American Journal of Botany, Volume 113, Issue 6, June 2026.
Abstract Premise Global climate change has altered the eco‐evolutionary trajectories of plant species, leading to observed shifts in phenotypes, such as earlier flowering. However, disentangling the contributions of plasticity and adaptation to trait changes remains challenging.
Lillie K. Pennington, Seema N. Sheth, Steven J. Franks, Jill T. Anderson, Elena Hamann   +4 more
wiley   +1 more source

Misdiagnosed, misunderstood and missing out: Lynch Syndrome, Australia's untold health story

, 2017
Rice, Toni, O'Neill, Sharron ; https://orcid.org/, Morris, Susan, Fairbank, Beth, Raets, Eve   +4 more
core   +1 more source

Multiple Primary Malignancies in Patients With Gastric Cancer: A Retrospective Study in National Cancer Center of China

Cancer Innovation, Volume 5, Issue 3, June 2026.
This study demonstrates multiple primary malignancies (MPMs) occur in 4.01% of gastric cancer patients and most commonly involve the esophagus, colorectum, and lung. Distinct differences are observed between synchronous and metachronous cases. These findings establish a clinical and epidemiological framework to inform future investigations into MPMs in
Guiling Zhu, Yutong Li, Bingzhi Wang, Liyan Xue, Yuchen Jiao, Xiaobing Wang, Chunxia Du   +6 more
wiley   +1 more source

Distinct Germline Mutation Landscape and Clinical Implications in Chinese Colorectal Cancer: A Large‐Scale Genomic Analysis of 1094 Patients

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Objective To investigate the prevalence, characteristics, and clinical implications of germline mutations in a consecutive cohort of Chinese colorectal cancer (CRC) patients, providing insights that may inform population‐specific genetic testing strategies.
Liting Lu, Xinyu Peng, Jiaxin Zhang, Yixin Ding, Junliang Lu, Hengxue Lin, Huanwen Wu, Xicheng Wang, Yi Ba   +8 more
wiley   +1 more source

Expanding diagnostic approaches for Lynch syndrome

Currently, there are ~1,000 families who have attended Family Cancer Clinics across Australia who have the hallmarks of having Lynch syndrome, a hereditary bowel cancer syndrome, but who have no gene defect identified, i.e.

core   +1 more source

Endometrial Cancer of the Uterine Isthmus: A Cohort Study on Clinicopathological Features and Prognosis

Cancer Medicine, Volume 15, Issue 6, June 2026.
The study compared the clinicopathologic characteristics and prognosis of patients with uterine isthmus cancer to those with uterine fundus cancer. The aim was to identify risk variables associated with the prognosis of patients with isthmus cancer. Uterine isthmus cancer demonstrates a higher stage, a stronger tendency for adjuvant therapy, and a more
Hao Wang, Peijie Xiao, Chendi Zhu, Jinxia Zhou, Chunhua Yang, Paulo Moreira, Li Yan   +6 more
wiley   +1 more source

Genomics of Lynch syndrome and Constitutional mismatch repair deficiency syndrome [PDF]

, 2018
Introduction: The mismatch repair system plays an important role in maintaining the genome integrity as it functions to correct mismatches during DNA replication. Heterozygous mutations in one of the mismatch repair (MMR) genes e.g.
Lamola, Lindiwe
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