Results 21 to 30 of about 34,914 (256)
Hereditary Cancer in Clinical Practice, 2019 Background Lynch syndrome, a hereditary cancer syndrome, predisposes women to colorectal, endometrial, and ovarian cancer. Current guidelines recommend that women with Lynch syndrome undergo risk-reducing gynecological surgery to reduce their chances of ...
Kaitlin M. McGarragle +7 more
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Lynch syndrome: An unusal case of familial cancer unearthed
Indian Journal of Pathology and Microbiology, 2022 Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) is a type of inherited cancer syndrome with a genetic predisposition to different types of cancer.
Subhra Dhar +4 more
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BMC Health Services Research, 2022 Background Lynch syndrome is an underdiagnosed hereditary condition carrying an increased lifetime risk for colorectal and endometrial cancer and affecting nearly 1 million people in the United States.
Lauren Passero +6 more
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Endometrial Cancer Diagnosed at an Early Stage during Lynch Syndrome Surveillance: A Case Report
Case Reports in Oncology, 2023 Lynch syndrome is an autosomal dominant inherited disorder caused by a germline pathogenic variant in DNA mismatch repair genes, resulting in multi-organ cancer.
Maki Umemiya +11 more
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Pathological diagnosis experience and literature review of four cases suspected Lynch-like syndrome
Frontiers in OncologyBackgroundAmong CRC patients with mismatch repair protein deficiency or microsatellite instability (MSI), up to 50% of cases lack germline mutations in MMR genes, BRAF mutations, or MLH1 promoter methylation. Such cases are defined as Lynch-like syndrome
Bo Cheng +8 more
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The prevalence of Lynch syndrome in women with endometrial cancer: a systematic review protocol
Systematic Reviews, 2018 Background Lynch syndrome is the most common inherited cancer syndrome, which predisposes individuals to a number of different cancers, principally colorectal and endometrial cancer.
Neil A. J. Ryan +5 more
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Frontiers in Medicine, 2022 BackgroundLynch syndrome is an autosomal dominant disorder associated with a high incidence of various cancer types. Multiple variants of mismatch repair genes have been reported for Lynch syndrome. However, the diagnosis in patients with atypical cancer
Lu Li +7 more
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Integrative omics approaches to uncover liquid-based cancer-predicting biomarkers in Lynch syndrome. [PDF]
Int J CancerWhat's new? Lynch syndrome (LS) significantly increases lifetime cancer risk, necessitating innovative approaches for risk stratification. Current risk assessment methods, however, fail to integrate data from different biological systems, which may be influenced by lifestyle factors.
Kärkkäinen M +9 more
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Differential diagnosis of small bowel occlusions
Clinical Management Issues, 2009 Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a common autosomal dominant syndrome characterized by early age at onset, and microsatellite instability (MSI).
Paolo Ghiringhelli
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Frontiers in Genetics, 2022 Background: Lynch syndrome is a genetic disease resulting from mismatch repair gene mutation. Vaccine therapy can enhance the immunogenicity of Lynch syndrome and improve the therapeutic efficacy of immunotherapy.
Kai Ye +4 more
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