Results 51 to 60 of about 34,914 (256)

Treatment and Outcomes for Patients With Inadequate Lymphadenectomy After Resection of Stage II Small Bowel Adenocarcinoma

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Adjuvant chemotherapy (AC) is considered for patients with stage II small bowel adenocarcinoma (SBA) with an inadequate lymphadenectomy; however, the prognostic role of additional high‐risk features (T4 primary, positive resection margin, poorly differentiated tumor, or lymphovascular invasion) is unknown.
Jackson A. Baril, Karl Y. Bilimoria, Eugene P. Ceppa, Michael G. House, Thomas K. Maatman, Alexandra M. Roch, Anthony D. Yang, C. Max Schmidt, Ryan J. Ellis   +8 more
wiley   +1 more source

Compliance of Dermatology Screening Visits Among Patients With Skin Cancer‐Predisposing Pathogenic Variants

JEADV Clinical Practice, EarlyView.
Patients with genetic variants that increase skin cancer risk are recommended to undergo regular dermatology screenings per National Comprehensive Cancer Network guidelines, but compliance is uncertain. In a retrospective study of 230 patients with such variants, compliance with screening visits significantly improved after visiting a Hereditary Cancer
Stephen J. Gadomski, Kevin S. Hughes, Jihad S. Obeid, Courtney Rowley, Graciela De Jesús   +4 more
wiley   +1 more source

Contralateral lymph node metastasis in recurrent ipsilateral breast cancer with Lynch syndrome: a locoregional event [PDF]

, 2022
Tibor A. Zwimpfer, Fabienne D. Schwab, Daniel Steffens, Felix Kaul, Noemi Schmidt, James D. Geiger, Franziska Geissler, Viola Heinzelmann‐Schwarz, William P. Weber, Christian Kurzeder   +9 more
openalex   +1 more source

Dupilumab Treatment in Pemphigus: A Report of Three Cases and Literature Review

JEADV Clinical Practice, EarlyView.
ABSTRACT Pemphigus vulgaris (PV) and foliaceus (PF) are rare autoimmune blistering diseases traditionally treated with systemic corticosteroids, immunosuppressants, intravenous immunoglobulins, and rituximab. Nonetheless, a subset of patients remains refractory or has contraindications to these conventional therapies.
José Javier Mateos Rico, Marta Gutiérrez Pascual, María Dolores Caro Gutiérrez, Cristina Marcos Rodríguez, Javier de Quadros Malagón, Francisco Javier Vicente Martín   +5 more
wiley   +1 more source

Lynch syndrome caused by SINE-VNTR-Alu-F retrotransposon insert in MSH6 confirmed after 20 years of testing: a case report and literature review

Hereditary Cancer in Clinical Practice
Background Lynch syndrome is due to error in DNA mismatch repair (MMR) genes caused by germline pathogenic variants. For some families highly suspicious of Lynch syndrome, the diagnosis may not be confirmed.
Wenche Sjursen, Eva Kathrine Svaasand, Bodil Gilde, Anuradha Ravi, Katinka Madtzog Korseth, Ashish Kumar Singh, Jostein Johansen, Olaug Kristin Rødningen, Sofie Geck Sevatdal, Siv Anita Hegre, Maren Fridtjofsen Olsen, Kristine Misund   +11 more
doaj   +1 more source

Acceleration of the DNA methylation clock among lynch syndrome-associated mutation carriers

BMC Medical Genomics, 2022
Background DNA methylation (DNAm) age metrics have been widely accepted as an epigenetic biomarker for biological aging and disease. The purpose of this study is to assess whether or not individuals carrying Lynch Syndrome-associated mutations are ...
Marta Cuadros, Carlos Cano, Sonia Garcia-Rodriguez, José Luis Martín, Antonio Poyatos-Andujar, Francisco Ruiz-Cabello, Susana Pedrinaci, Gema Durán, Manuel Benavides, María Dolores Bautista-Ojeda, Teresa Pereda, Maria Soledad Benitez-Cantos, Pedro Medina, Armando Blanco, Antonio Gonzalez, Paul Lizardi   +15 more
doaj   +1 more source

Exome Sequencing Identifies Variants in MLH1 and ERBB2 as Potential Cancer‐Predisposing Factors in Familial Early‐Onset Colorectal Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Colorectal cancer (CRC) has raised considerable health concerns worldwide, with increasing incidence rates, specifically among younger populations. Despite remarkable progress in diagnosing and treating various diseases, the genetic basis of CRC remains only partially understood.
Behnaz Bagheri, Neda Mohsen‐Pour, Najmeh Salehi, Pardis Ketabi Moghadam, Adel Zeinalpour, Amir Sadeghi, Samira Kalayinia, Nayeralsadat Fatemi   +7 more
wiley   +1 more source

Unusual presentation of Lynch Syndrome

Hereditary Cancer in Clinical Practice, 2009
Lynch Syndrome/HNPCC is a syndrome of cancer predisposition linked to inherited mutations of genes participating in post-replicative DNA mismatch repair (MMR).
Yu Veronica PCC, Novelli Marco, Payne Stewart J, Fisher Sam, Barnetson Rebecca A, Frayling Ian M, Barrett Ann, Goudie David, Ardern-Jones Audrey, Eeles Ros, Shanley Susan   +10 more
doaj   +1 more source

A common genetic variation in GZMB may associate with cancer risk in patients with Lynch syndrome [PDF]

, 2023
Vince Kornél Grolmusz, Petra Nagy, István Likó, Henriett Butz, Tímea Pócza, Anikó Bozsik, J. Papp, Edith Oláh, Attila Patócs   +8 more
openalex   +1 more source

Long‐term clinical and MRI outcomes of a polyurethane meniscal scaffold implantation for the treatment of partial meniscal deficiency: A minimum 10‐year follow‐up study

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To assess the clinical and magnetic resonance imaging (MRI) results after implantation of a polyurethane scaffold for chronic segmental meniscus deficiency following partial meniscectomy in a long‐term follow‐up. Study Design Level IV, retrospective case series. Methods Thirty‐two knees received arthroscopic implantation of an Actifit®
Vasileios S. Akrivos, George A. Komnos, Bela Ujvari, Artemis Hante, Eleftheria Adaktylidou, Theofilos Karachalios, Michael Hantes   +6 more
wiley   +1 more source