Results 51 to 60 of about 880 (178)

Trehalose Crystallization During Freeze-Drying: Implications On Lyoprotection

, 2015
Lyoprotectants are stabilizers used to prevent denaturation of proteins during freeze-drying and subsequent storage. In order to be effective, lyoprotectants must be retained amorphous.
Raj Suryanarayanan (1246851), Prakash Sundaramurthi (1268358)   +1 more
core   +1 more source

Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization

International Journal of Nanomedicine, 2016
Rebecca L Ball,1 Palak Bajaj,1,2 Kathryn A Whitehead1,2 1Department of Chemical Engineering, 2Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA Abstract: The broadest clinical application of siRNA therapeutics will ...
Ball RL, Bajaj P, Whitehead KA
doaj  

Conservation of Microorganisms of Biotechnological Interest

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Food Science and Technology
Thirty strains of microorganisms from the National Collection of Nonpathogenic Microorganisms (NCNM) were used as study objects (actinobacteria, bacteria, and micromycetes).
Tamara SÎRBU, Cristina MOLDOVAN, Valerian SLANINA, Maxim BÎRSA   +3 more
doaj   +1 more source

Lyoprotectant Constituents Suited for Lyophilization and Reconstitution of Stem-Cell-Derived Extracellular Vesicles. [PDF]

Biomater Res
Stem-cell-derived extracellular vesicles (EVs) are emerging as an alternative approach to stem cell therapy. Successful lyophilization of EVs could enable convenient storage and distribution of EV medicinal products at room temperature for long periods, thus considerably increasing the accessibility of EV therapeutics to patients.
Kang WY, Shin EK, Kim EH, Kang MH, Bang CY, Bang OY, Cha JM.   +6 more
europepmc   +3 more sources

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, Volume 2, Issue 2, April 2026.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source

Excipients for the lyoprotection of MAPKAP kinase 2 inhibitory peptide nano-polyplexes

Journal of Controlled Release, 2018
Herein, excipients are investigated to ameliorate the deleterious effects of lyophilization on peptide-polymer nano-polyplex (NP) morphology, cellular uptake, and bioactivity. The NPs are a previously-described platform technology for intracellular peptide delivery and are formulated from a cationic therapeutic peptide and the anionic, pH-responsive ...
Alvin J, Mukalel, Brian C, Evans, Kameron V, Kilchrist, Eric A, Dailing, Benjamin, Burdette, Joyce, Cheung-Flynn, Colleen M, Brophy, Craig L, Duvall   +7 more
openaire   +3 more sources

Transcatheter Intra‐Arterial Delivery of a Platelet‐Derived Extracellular Vesicle‐Enriched Preparation for Attenuating Skeletal Muscle Ischaemia‐Reperfusion Injury in a Rodent Forelimb Model

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Extracellular vesicles (EVs) are non‐replicating, lipid membrane‐bound nanoparticles released by most eukaryotic cells into the extracellular space. When derived from platelets, a subset of EVs can exhibit remarkable anti‐inflammatory and antioxidant properties, making them attractive candidates to attenuate sterile inflammatory states such as
Omar A. Selim, Aida Sarcon, Atta Behfar, Chunfeng Zhao, Steven L. Moran   +4 more
wiley   +1 more source

Near-Infrared Spectroscopy for In-Line Monitoring of Protein Unfolding and Its Interactions with Lyoprotectants during Freeze-Drying

, 2016
This work presents near-infrared spectroscopy (NIRS) as an in-line process analyzer for monitoring protein unfolding and protein-lyoprotectant hydrogen bond interactions during freeze-drying.
Dorien Boulpaep (2123101), Christophe Tistaert (2068387), Chris Vervaet (429465), Julia Christina Kasper (2123104), Oliwia Waszkiewicz (2123107), Yvan Vander Heyden (2068390), Mohammad Goodarzi (2123098), Jean-Paul Remon (2123113), Thomas De Beer (1427926), Sigrid Pieters (2123110), Wolfgang Friess (1607515)   +10 more
core   +1 more source

The mechanisms of Wickhamomyces anomalus in control of postharvest black spot disease in tomatoes and the preparation of its biocontrol solid products

Agriculture Communications
Postharvest black spot of tomato causes considerable economic losses to the tomato industry. Biological control presents a sustainable and efficient alternative. This study investigated the biocontrol mechanism of Wickhamomyces anomalus and optimized its
Xi Zhang, Marui Zhu, Dhanasekaran Solairaj, Kaili Wang, Qiya Yang, Hongyin Zhang   +5 more
doaj   +1 more source

Extracellular Vesicles and Lyophilization: Getting Functionally Stable Cell-free Biomedical Products [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy
During the last decade, clinical application of extracellular vesicles (EVs) is of growing interest. Despite the progress in exploring the therapeutic potential of EVs, e.g.
Abay Baigenzhin, Elmira Chuvakova, Aigerim Zhakupova, Aizhan Akhayeva, Anastasia Ganina   +4 more
doaj   +1 more source