Results 71 to 80 of about 880 (178)

Hyperspectral Imaging Techniques for Lyophilization: Advances in Data‐Driven Modeling Strategies and Applications

Advanced Science, Volume 12, Issue 33, September 4, 2025.
Lyophilization is a key process used in the production of biotherapeutic products. This article reviews and discusses the application of HSI on lyophilization, and the strategies that use the resulting data to build models. It is intended to provide guidance and insights for non‐specialist researchers and engineers into leveraging HSI and the data ...
Huiwen Yu, Prakitr Srisuma, Cedric Devos, Jie Wang, Allan S. Myerson, Richard D. Braatz   +5 more
wiley   +1 more source

Stability insights into synthetic biology enabled biosensors: A case study with SARS-CoV2 toehold-based colorimetric sensor

Sensing and Bio-Sensing Research
Improving medical and environmental diagnostics has become a pressing need. Synthetic biologists are steering biomolecular engineering efforts toward this objective, promising novel, cost-effective diagnostic solutions.
Swetha Mariam Stanley, Harvinder Khera
doaj   +1 more source

Exploring the chemical space for freeze-drying excipients

, 2019
Commonly, a limited number of generally accepted bulking agents and lyoprotectants are used for freeze-drying; predominantly mannitol, glycine, sucrose and trehalose.
Holm, Tobias Palle, Poso, Antti, Rantanen, Jukka, Jorgensen, Lene, Meng-Lund, Helena, Grohganz, Holger   +5 more
core   +1 more source

Development of a Thermostable Freeze-Dried Live Pseudorabies Vaccine Based on the PRV Bartha-K61 Strain: Formulation Optimization, Stability Evaluation, and Preliminary Immunogenicity in Piglets

Vaccines
Background: Pseudorabies vaccines based on the live attenuated PRV Bartha-K61 strain remain essential for controlling pseudorabies in swine, but poor thermal stability during storage and transport limits field use. Objectives: This study aimed to develop
Yanhong Zhao, Xiaoqing Pan, Fang Lv, Yalu Zhu, Zhen Wang, Yu Lu, Endong Bao   +6 more
doaj   +1 more source

Development of ginkgolide B nanocrystals via miniaturized wet bead milling: A QbD approach

Pakistan Journal of Pharmaceutical Sciences
Background: Ginkgolide B (GB), a potent platelet-activating factor antagonist with multi-faceted pharmacological effects, suffers from extremely low oral bioavailability due to poor aqueous solubility and permeability.
Yun Liu, Hengyu Xu, Meili Lu
doaj   +1 more source

Annealing Properties of Lyoprotectant Solution [PDF]

Acta Physico-Chimica Sinica, 2005
ZUO Jian-guo, HUA Ze-zhao, LIU Baolin, ZHOU Guoyan, XU Yi   +4 more
openaire   +1 more source

Unexpectedly enhanced stereoselectivity of peroxidase-catalyzed sulfoxidation in branched alcohols

, 2002
Lyophilized horseradish peroxidase (HRP) exhibits poor stereoselectivity in the sulfoxidation of thioanisole when the enzyme is either redissolved in water or suspended in organic solvents.
Das, Prasanta Kumar, Xie, Yuchun, Caaveiro, Jose M. M., Klibanov, Alexander M.   +3 more
core   +1 more source

Effect of Protectants on the Survival Rate of Freeze-dried Lactic Acid Bacteria

Effect of lyoprotectants on the survival rate of freeze-dried lactic acid bacteria was investigated.Freeze-drying and preservation of the bacteria with disaccharides (sucrose and trehalose) andbovine serum albumin (BSA) achieved much higher survival ...
川井, 清司, 三ヶ尻, 脩人, 黄川田, 隆洋, 鈴木, 大, 萩原, 知明, 鈴木, 徹, 滕, 達, Hagiwara, Tomoaki, ハギワラ, トモアキ, スズキ, トオル, Suzuki, Toru, 羽倉, 義雄   +11 more
core   +1 more source

The effect of lyophilization and cryoprotection on survival of Lactiplantibacillus plantarum strains

Пищевые системы
Lyophilization has been recognized for many years as an effective method for storing collection cultures, bacterial starter cultures, and probiotics.
N. P. Sorokina, I. T. Smykov, I. V. Kucherenko, E. V. Kuraeva, A. Yu. Duganova   +4 more
doaj   +1 more source

Rational design of an influenza subunit vaccine powder with sugar glass technology:preventing conformational changes of haemagglutinin during freezing and freeze-drying

, 2007
The development of a stable influenza subunit vaccine in the dry state was investigated. The influence of various carbohydrates, buffer types and freezing rates on the integrity of haemagglutinin after freeze-thawing or freeze-drying was investigated ...
Hinrichs, W L J; id_orcid, Meulenaar, J, Frijlink, H W; id_orcid, Coenen, F, Huckriede, A, Hinrichs, W L J, Frijlink, H W, Amorij, J-P, Stegmann, T   +8 more
core   +1 more source