Results 61 to 70 of about 880 (178)

Assessment and determination of lyoprotectant for survival of freeze-dried Lactobacillus rhamnosus

Acta Universitatis Cibiniensis. Series E: Food Technology, 2016
Abstract Currently research of lactic acid bacteria focus primarily on the functional probiotics, which are major beneficial biota in the gastrointestinal tract, have been industrial manufactured. Probiotics confer health benefits on the host need adequate amounts. However, the absence of data makes it difficult to ensure the maintenance
Miao Zongcheng, Zhao Yang, Huo Xiaoping
openaire   +2 more sources

Screening and Identification of Triglyceride‐Lowering Lactic Acid Bacteria and Preparation of Probiotic Agents

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
This study isolated and identified six lactic acid bacteria strains from various fermented foods. Through 16S rRNA sequencing, they were classified as Limosilactobacillus fermentum (PYC02, MHT02, SS01, SC03) and Weissella cibaria (PLHB02, SZ02). Their stress tolerance and safety were evaluated.
Xinglin Ran, Qian Hu, Shengdan Wei, Huizhen Long, Xu Luo, Boyu Dong, Qiuping Yao, Dequan Zhu   +7 more
wiley   +1 more source

Near-infrared spectroscopy for in-line monitoring of protein unfolding and its interactions with lyoprotectants during freeze-drying

, 2011
This work presents near-infrared spectroscopy (NIRS) as an in-line process analyzer for monitoring protein unfolding and protein-lyoprotectant hydrogen bond interactions during freeze-drying.
Remon, Jean Paul, De Beer, Thomas, Vervaet, Chris, Sigrid Pieters, Waszkiewicz, Oliwia, Kasper, Julia, Goodarzi, Mohammad, Tistaert, Christophe, Mohammad Goodarzi, Yvan Vander Heyden, Friess, Wolfgang, Julia Christina Kasper, Chris Vervaet, Thomas De Beer, Jean-Paul Remon, Pieters, Sigrid, Wolfgang Friess, Dorien Boulpaep, Oliwia Waszkiewicz, Christophe Tistaert, Vander Heyden, Yvan, Boulpaep, Dorien   +21 more
core   +1 more source

Stabilized Extracellular Vesicle Formulations for Inhalable Dry Powder Development

Small, Volume 22, Issue 16, 17 March 2026.
Extracellular vesicles (EVs) hold promise for chronic obstructive pulmonary disease (COPD) treatment but face challenges with storage and delivery. This study demonstrates the stabilization of lung fibroblast‐derived EVs using inulin, enabling freeze‐drying and spray‐drying.
Eva M. Jansen, Luke van der Koog, Robin A.B. Elferink, Karim Rafie, Anika Nagelkerke, Reinoud Gosens, Henderik W. Frijlink, Wouter L.J. Hinrichs   +7 more
wiley   +1 more source

Preliminary formulation development of silicone elastomer vaginal rings for sustained release of metronidazole, sucrose and lactobacillus [PDF]

, 2021
Background: Bacterial vaginosis (BV) is a common dysbiosis of the human vagina in which commensal vaginal lactobacilli are displaced by mixed pathogenic bacterial populations.
Kett, Victoria; id_orcid, Wang, Caixuan, Malcolm, Karl; id_orcid, Gilpin, Deirdre   +3 more
core   +2 more sources

Drug Product Development of Lipid Nanoparticle‐Based mRNA Therapeutics and Vaccines

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.
Overview of the development path from an mRNA–lipid nanoparticle (LNP) concept to a licensed drug product, covering LNP design, manufacturing process development, formulation, and analytical characterization. ABSTRACT Lipid nanoparticles (LNP) are currently the most relevant non‐viral delivery systems for mRNA and occasionally for smaller nucleic acids
Gideon Kersten, Eleonora Cerasoli, Bruce Kerwin, Olivia M. Merkel, Andrea Hawe   +4 more
wiley   +1 more source

Excipients activate peroxidases in specific but not in non-specific reactions in organic solvents

, 2001
Co-lyophilization with ligands and lyoprotectants markedly activated horseradish and soybean peroxidases in the oxidation of guaiacol in organic solvents (Dai and Klibanov (1999) Proc. Natl. Acad. Sci. USA96: 9475–9478).
Das, Prasanta Kumar, Yuchun, Xie, Klibanov, Alexander M.   +2 more
core   +1 more source

Freezing the Moment: Monitoring Freezing Processes Under MAS Conditions

Magnetic Resonance in Chemistry, Volume 64, Issue 2, Page 193-206, February 2026.
NMR spectroscopy under magic angle spinning conditions allows studying the freezing of aqueous solutions and gel‐like systems down to subfreezing temperatures. We thoroughly monitored the freezing process of various aqueous systems containing multiple NMR‐active nuclei (1H, 11B, 13C, 23Na, and 79Br). We focus on prerequisites, problems, and limitations
Sebastian Scheidel, Elena Behr, Ann‐Christin Pöppler   +2 more
wiley   +1 more source

Injectable Chitosan‐Platelet‐Rich Plasma Hybrid Biomaterial Improves Skin Wound Healing in Diabetic Rats

Advanced Therapeutics, Volume 9, Issue 1, January 2026.
A biomaterial combining fresh platelet‐rich plasma with freeze‐dried chitosan (CS‐PRP) enhances diabetic skin wound healing in rats. CS‐PRP accelerates closure over the course of a month, improves healing tissue architecture and collagen remodeling, and sustains vascularization.
Laura Ahunon, Anik Chevrier, Léo‐Paul Tricou, Aurélie Huppé, Julie Fradette, Marc Lavertu   +5 more
wiley   +1 more source

Protective Effects Proanthocyanidin Nanoliposome Freeze‐Dried Powder on Oxidative Injury in a p31‐43 Induced Celiac Disease Cell Model

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
Proanthocyanidin nanoliposome freeze‐dried powder (PCNL‐FD) with 4% trehalose maintained excellent stability and encapsulation efficiency, demonstrating enhanced antioxidant activity compared to free proanthocyanidins. In a celiac disease cell model, PCNL‐FD significantly reduced oxidative stress by decreasing ROS and MDA while increasing GSH and ...
Zhou Ning, Chen Linlin, Zhang Xing, He Kunmiao, Xu Tiantian, Wang Hanshuo, Sun Jie, Yu Miao, Ren Hongtao, Wang Na   +9 more
wiley   +1 more source