Results 111 to 120 of about 996,868 (382)

Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism

open access: yesNature, 2019
Both single and multicellular organisms depend on anti-stress mechanisms that enable them to deal with sudden changes in the environment, including exposure to heat and oxidants.
V. Olin-Sandoval   +13 more
semanticscholar   +1 more source

Effect of dietary lysine on hepatic lysine catabolism in broilers ,

open access: yesPoultry Science, 2013
Lysine is frequently a first- or second-limiting amino acid in poultry diets. Improving the efficiency of lysine use for protein synthesis would effectively lower the lysine requirement and decrease feed costs. Understanding how lysine is degraded and how the degradation is regulated would identify potential molecular targets for interventions to ...
A S, Kiess   +4 more
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Alkyl substituted cucurbit[6]uril assisted competitive fluorescence recognition of lysine and methionine in aqueous solution [PDF]

open access: yes, 2017
The use of competitive ratiometric fluorescence indicator displacement chemosensors derived from two alkyl substituted cucurbit[6]uril-based host-guest complexes is reported.
Bai, Qinghong   +8 more
core   +1 more source

Cellular functions and molecular mechanisms of non-lysine ubiquitination

open access: yesOpen Biology, 2019
Protein ubiquitination is of great cellular importance through its central role in processes such as degradation, DNA repair, endocytosis and inflammation.
A. J. McClellan   +2 more
semanticscholar   +1 more source

Bioavailability of lysine from hydroxymethyl lysine

open access: yesKansas Agricultural Experiment Station Research Reports, 2010
Twelve mature sheep were used as a ruminant model to estimate the bioavailability of lysine in hydroxymethyl lysine (HML) compared with a commercial product of rumen-protected lysine (RPL; LysiPEARL, Kemin Industries, Inc.) with known availability. The sheep were fed a diet with a forage to concentrate ratio similar to that of dairy diets.
E.A. Elwakeel   +3 more
openaire   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Polypeptide gels incorporating the exotic functional aromatic amino acid 4-amino-L-phenylalanine [PDF]

open access: yes, 2018
High-molecular-weight polypeptides with functional aromatic side chains, poly(4-amino-l-phenylalanine), were prepared by the metal-initiated polymerization of the Nα-carboxyanhydride of the corresponding amino acid, which is a microbial derivative of ...
Ali, Mohammad Asif   +4 more
core   +1 more source

Bioavailability of lysine from a liquid lysine source in chicks

open access: yesPoultry Science, 1999
Two experiments were conducted to assess the bioavailability of lysine from a liquid lysine product (LLP; 60% lysine) relative to crystalline L-lysine.HCl. In the first experiment, four groups of five chicks were fed a lysine-deficient basal diet containing corn, soybean meal, and feather meal or the basal diet supplemented with 0.1 or 0.2% lysine from
J L, Emmert   +4 more
openaire   +2 more sources

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