Results 121 to 130 of about 996,868 (382)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation. [PDF]

, 2019
Molecular tweezers (MTs) are supramolecular host molecules equipped with two aromatic pincers linked together by a spacer (Gakh, 2018). They are endowed with fascinating properties originating from their ability to hold guests between their aromatic ...
Bitan, Gal, Hadrovic, Inesa, Klärner, Frank-Gerrit, Rebmann, Philipp, Schrader, Thomas   +4 more
core  

Toxin-neutralizing antibodies protect against Clostridium perfringens-induced necrosis in an intestinal loop model for bovine necrohemorrhagic enteritis [PDF]

, 2016
Background: Bovine necrohemorrhagic enteritis is caused by Clostridium perfringens type A. Due to the rapid progress and fatal outcome of the disease, vaccination would be of high value. In this study, C.
Deprez, Piet, Ducatelle, Richard, Goossens, Evy, Haesebrouck, Freddy, Pardon, Bart, Rodrigo, Diego, Schauvliege, Stijn, Timbermont, Leen, Valgaeren, Bonnie, Van Immerseel, Filip, Verherstraeten, Stefanie   +10 more
core   +2 more sources

Fully amino acid-based hydrogel as potential scaffold for cell culturing and drug delivery

Beilstein Journal of Nanotechnology, 2019
Polymer hydrogels are ideal scaffolds for both tissue engineering and drug delivery. A great advantage of poly(amino acid)-based hydrogels is their high similarity to natural proteins. However, their expensive and complicated synthesis often limits their
Dávid Juriga, Evelin Sipos, Orsolya Hegedűs, Gábor Varga, Miklós Zrínyi, Krisztina S. Nagy, Angéla Jedlovszky-Hajdú   +6 more
doaj   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Uncoupled Phosphorylation and Activation in Bacterial Chemotaxis - The 2.3 Å structure of an aspartate to lysine mutant at position 13 of CheY [PDF]

, 1997
An aspartate to lysine mutation at position 13 of the chemotaxis regulatory protein CheY causes a constitutive tumbly phenotype when expressed at high copy number in vivo even though the mutant protein is not phosphorylatable.
Bourret, Robert B., Jiang, Meiying, Sinsheimer, Melvin I., Volz, Karl   +3 more
core  

Sirtuin 1 Inhibiting Thiocyanates (S1th)—A New Class of Isotype Selective Inhibitors of NAD+ Dependent Lysine Deacetylases [PDF]

, 2020
Nathalie Wössner, Zayan Alhalabi, Jessica González, Sören Swyter, Gan Jin, Matthias Schmidt, Lin Zhang, Alejandro Vaquero, Huib Ovaa, Oliver Einsle, Wolfgang Sippl, Manfred Jung   +11 more
openalex   +1 more source

Lysine catabolism reprograms tumour immunity through histone crotonylation

Nature, 2023
Huairui Yuan, Xujia Wu, Qiulian Wu, Adam Chatoff, Emily Megill, Jinjun Gao, Tengfei Huang, Tingting Duan, Kailin Yang, Chunyu Jin, Fanen Yuan, Shuai Wang, Linjie Zhao, P. Zinn, K. Abdullah, Yingming Zhao, N. Snyder, Jeremy N. Rich   +17 more
semanticscholar   +1 more source

Identification of amino acids essential for angulin‐1/3 binding of the tricellular tight junction binder, angubindin‐1

FEBS Open Bio, EarlyView.
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu, Yumi Iwashita, Keisuke Tachibana, Itsuki Nishino, Yuki Niwa, Atsuko Uyeda, Kazuki Matsuo, Masahiro Nagahama, Masuo Kondoh   +8 more
wiley   +1 more source

Detection of DNA and Poly-L-Lysine using CVD Graphene-channel FET Biosensors

, 2015
A graphene channel field-effect biosensor is demonstrated for detecting the binding of double-stranded DNA and poly-l-lysine. Sensors consist of CVD graphene transferred using a clean, etchant-free transfer method.
Abhilash, T. S., Craighead, Harold G, De Alba, Roberto, Kakatkar, Aniket, Parpia, Jeevak M   +4 more
core   +1 more source