Upregulation of Transglutaminase andε(γ-Glutamyl)-Lysine in the Fisher-Lewis Rat Model of Chronic Allograft Nephropathy [PDF]
, 2014 Background. Tissue transglutaminase (TG2), a cross-linking enzyme, modulates deposition of extracellular matrix protein in renal fibrosis. This study aimed to examine TG2 and its cross-link product ε(γ-glutamyl)-lysine in the Fisher-Lewis rat renal ...
Butt, Imran +7 more
core +3 more sources
Efficient Multiplex Gene Repression by CRISPR-dCpf1 in Corynebacterium glutamicum
Frontiers in Bioengineering and Biotechnology, 2020 Corynebacterium glutamicum is an important workhorse for industrial production of diversiform bioproducts. Multiplex control of metabolic pathway genes is crucial for maximizing biosynthesis of desired products.
Mingyue Li +9 more
doaj +1 more source
Encapsulation of ascorbic acid promotes the reduction of Maillard reaction products in UHT milk [PDF]
, 2016 The presence of amino groups and carbonyls renders fortified milk with ascorbic acid particularly susceptible to the reduction of available lysine and to the formation of Maillard reaction products (MRPs), as Nε-(Carboxyethyl)-L-lysine (CEL), Nε ...
Ahmed +36 more
core +5 more sources
LSD1: more than demethylation of histone lysine residues
Experimental and Molecular Medicine, 2020 Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified nuclear protein with histone demethylase activity. In particular, it plays a special role in the epigenetic regulation of gene expression, as it removes methyl ...
B. Perillo +3 more
semanticscholar +1 more source
Review of Lysine Metabolism with a Focus on Humans.
Journal of NutriLife, 2020 Lysine cannot be synthesized by most higher organisms and, therefore, is an indispensable amino acid (IAA) that must be consumed in adequate amounts to maintain protein synthesis.
D. Matthews
semanticscholar +1 more source
Suppressors of lysine codons may be misacylated lysine tRNAs [PDF]
Journal of Bacteriology, 1983 We describe a novel class of missense suppressors that read the codons for lysine at two positions (211 and 234) in the trpA polypeptide of Escherichia coli. The suppressor mutations are highly linked to lysT, a gene for lysine tRNA. The results suggest that the suppressors are misacylated lysine tRNAs that carry glycine or alanine.
E J Murgola, F T Pagel
openaire +3 more sources
Effect of bet missense mutations on bromodomain function, inhibitor binding and stability [PDF]
, 2016 Lysine acetylation is an important epigenetic mark regulating gene transcription and chromatin structure. Acetylated lysine residues are specifically recognized by bromodomains, small protein interaction modules that read these modification in a ...
Alessandra, Pasquo +7 more
core +2 more sources
Regulation of Cellular Metabolism by Protein Lysine Acetylation
Science, 2010 Metabolic Regulation Through Acetylation Covalent modification of lysine residues in various proteins in the nucleus is a recognized mechanism for control of transcription.
Shimin Zhao +21 more
semanticscholar +1 more source
Lysine/RNA-interactions drive and regulate biomolecular condensation
Nature Communications, 2019 Cells form and use biomolecular condensates to execute biochemical reactions. The molecular properties of non-membrane-bound condensates are directly connected to the amino acid content of disordered protein regions.
T. Ukmar-Godec +9 more
semanticscholar +1 more source
L-methionine supplementation modulates IgM+ B cell responses in rainbow trout
Frontiers in Immunology, 2023 The interest in dietary amino acids (AAs) as potential immunomodulators has been growing the recent years, since specific AAs are known to regulate key metabolic pathways of the immune response or increase the synthesis of some immune-related proteins ...
Diana Martín +12 more
doaj +1 more source