Fully amino acid-based hydrogel as potential scaffold for cell culturing and drug delivery
Beilstein Journal of Nanotechnology, 2019 Polymer hydrogels are ideal scaffolds for both tissue engineering and drug delivery. A great advantage of poly(amino acid)-based hydrogels is their high similarity to natural proteins. However, their expensive and complicated synthesis often limits their
Dávid Juriga +6 more
doaj +1 more source
The bromodomain-containing protein Ibd1 links multiple chromatin related protein complexes to highly expressed genes in Tetrahymena thermophila [PDF]
Epigenetics & Chromatin (2018) 11:10, 2018 Background: The chromatin remodelers of the SWI/SNF family are critical transcriptional regulators. Recognition of lysine acetylation through a bromodomain (BRD) component is key to SWI/SNF function; in most eukaryotes, this function is attributed to SNF2/Brg1.
arxiv +1 more source
Lysine/RNA-interactions drive and regulate biomolecular condensation
Nature Communications, 2019 Cells form and use biomolecular condensates to execute biochemical reactions. The molecular properties of non-membrane-bound condensates are directly connected to the amino acid content of disordered protein regions.
T. Ukmar-Godec +9 more
semanticscholar +1 more source
Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I [PDF]
, 2007 Glutaric acidemia type I (GA-I) is an inherited disorder of lysine and tryptophan metabolism presenting with striatal lesions anatomically and symptomatically similar to Huntington disease.
Banos +30 more
core +3 more sources
Frontiers in Microbiology, 2022 The effects of fiber, complex carbohydrates, lipids, and small molecules from food matrices on the human gut microbiome have been increasingly studied.
Nate Korth +16 more
doaj +1 more source
Detection of DNA and Poly-L-Lysine using CVD Graphene-channel FET Biosensors
, 2015 A graphene channel field-effect biosensor is demonstrated for detecting the binding of double-stranded DNA and poly-l-lysine. Sensors consist of CVD graphene transferred using a clean, etchant-free transfer method.
Abhilash, T. S. +4 more
core +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Hyaluronan-Arginine Enhanced Interaction Emerges from Distinctive Molecular Signature with Improved Electrostatics and Side-Chain Specificity [PDF]
arXiv, 2023 Hyaluronan, a sugar polymer found outside the plasma membrane, is a critical component of the extracellular matrix (ECM) scaffold. Hyaluronan's length and moderate negative charge aid in ECM entanglement and solubility. This allows it to effectively foster gel-like conditions, which are critical for supporting and protecting cells in various tissues ...
arxiv
Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases [PDF]
Chemical Communications, 2020 Histone lysine methyltransferases (KMTs) exhibit substrate specificity for lysine and its geometrically constrained mimics.
Marcus J M Mulders +8 more
openaire +7 more sources
Single-phase feeding and compensatory growth in growing and finishing pigs (OK-Net Ecofeed Practice Abstract) [PDF]
, 2020 • Limit the supply of essential amino acids during early growth and utilise the pigs’ capacity to fully compensate for the restriction by increased protein retention and faster growth during later growth phases.
Åkerfeldt, Magdalena
core