Results 71 to 80 of about 2,589 (171)

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source

Lactylation-stabilized NOL6 promotes colorectal cancer progression via STAMBP-mediated YY1 deubiquitination and c-Myc transcription upregulation

Cell Reports
Summary: Colorectal cancer (CRC) represents a significant menace to human health, but its molecular pathogenesis remains unclear. Herein, we explored the functional role of spindle and nucleolar protein 6 (NOL6) in CRC progression.
Hao Zhang, Ye Han, Jiaqi Wang, Chunlin Wang, Zewen Chang, Jun Xiang, Hanqing Hu, Ziming Yuan, Nana Zhang, Yuliuming Wang, Chenkai Zhang, Yunxiao Liu, Chengwei Wu, Jian Ma, Xianli Zhou, Guiyu Wang   +15 more
doaj   +1 more source

Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang, Lu Shi, Liangliang Lin, Yang Zhang, Miao Zhang, Lili Wu, Yong Xia, Yaqiong Zhang, Peng Han, Likun Zhuang, Liang Shi   +10 more
wiley   +1 more source

Lactylproteome analysis indicates histone H4K12 lactylation as a novel biomarker in triple-negative breast cancer

Frontiers in Endocrinology
ObjectiveThe established link between posttranslational modifications of histone and non-histone lysine (K) residues in cell metabolism, and their role in cancer progression, is well-documented.
Zhaolei Cui, Yanhong Li, Yingying Lin, Chaoqiang Zheng, Lingqing Luo, Dan Hu, Yan Chen, Zhenzhou Xiao, Yang Sun   +8 more
doaj   +1 more source

Post‐Translational Modifications in Animal Circadian Clocks

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Circadian clocks coordinate physiology with daily environmental cycles through conserved transcriptional–translational feedback loops. This review summarizes how post‐translational modifications fine‐tune clock function, highlights the evolutionary convergence of circadian timekeeping in Drosophila and mammals, and emphasizes the central of these ...
Xianhui Liu, Yong Zhang
wiley   +1 more source

MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis

Advanced Science
Lactate plays diverse roles in brain pathophysiology, including ischemic stroke. Here, the role of lysine lactylation, an epigenetic modification of lactate, in cerebral ischemia is investigated.
Min Sun, Yuxin Zhang, Rui Mao, Yan Chen, Pinyi Liu, Lei Ye, Siyi Xu, Junqiu Jia, Shu Shu, Huiya Li, Yanping Yin, Shengnan Xia, Yanting Chen, Yun Xu   +13 more
doaj   +1 more source

Protein lactylation of citrate synthase promotes the AKI-CKD transition by activating the NLRP3 inflammasome

Cell Reports
Summary: Interstitial renal inflammation contributes to the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). Recently, lactylation modification has emerged as a mechanism for mediating chronic organ damage.
Fang Yu, Yan Meng, Xiaoyue Wang, Jia Chen, Junling He, Xiangling Yi, Yani He, Kehong Chen   +7 more
doaj   +1 more source

Engineered Bacteria‐Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity

Advanced Science, Volume 13, Issue 16, 18 March 2026.
We engineered a bacterial‐vesicular dual‐delivery platform that targets LOx to colorectal tumors, enabling lactate clearance, immune microenvironment remodeling, and microbiota modulation. This microbe–metabolism synergistic strategy effectively sensitizes colorectal cancer to radiotherapy, offering a promising approach to overcome radioresistance ...
Fei Peng, Zhe Lei, Zhehao Zhang, Zhiyue Su, Chonghai Zhang, Huan Yang, Shu Liu, Mengyuan Hu, Yuhong Wang, Lingchuan Guo, Lin Hu, Kai Yang   +11 more
wiley   +1 more source

Lactate‐induced metabolic reprogramming of TAMs impairs antigen presentation capacity via C/EBPα–CD74 axis in oral squamous cell carcinoma

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
• CD74hi TAMs correlate with favourable prognosis in OSCC. • Lactate reprograms TAMs metabolism and increases mitochondrial respiration. • C/EBPα acetylation suppresses CD74 and impairs antigen presentation. • Restoring CD74 enhances T‐cell activation and limits OSCC progression.
Mengyao Wang, Mengqi Wang, Zizhen Gong, Fanrui Zeng, Zihui Ni, Rundong Zhai, Weiwen Zhu, Jiayi Zhang, Laikui Liu   +8 more
wiley   +1 more source

Lactylation: a promising therapeutic target in ischemia-reperfusion injury management

Cell Death Discovery
Ischemia-reperfusion injury (IRI) is a critical condition that poses a significant threat to patient safety. The production of lactate increases during the process of IRI, and lactate serves as a crucial indicator for assessing the severity of such ...
Fei-xiang Wang, Guo Mu, Zi-hang Yu, Zu-an Shi, Xue-xin Li, Xin Fan, Ye Chen, Jun Zhou   +7 more
doaj   +1 more source