Results 91 to 100 of about 119,118 (204)

Histone Lactylation Drives WNK1 Expression to Promote Esophageal Squamous Cell Carcinoma Progression Through Histone H3 Ser10 Phosphorylation

Advanced Science, EarlyView.
In brief. Yan et al. demonstrated that the excess lactate produced by the enhanced glycolysis pathway in esophageal cancer can lactylate H3K23, H3K23la can be enriched in the WNK1 promoter region to promote WNK1 expression, thereby increasing the phosphorylation of the p‐H3 Ser10 site, and p‐H3S10 can be enriched in the AKT1 promoter region to promote ...
Mingyang Yan, Shaobo Fang, Yanming Song, Lei Zhang, Kexin Zhao, Zhenwei Wang, Yang Shao, Meng Liu, Xinyang Jia, Qinxin Guo, Mee‐Hyun Lee, Guoguo Jin, Zigang Dong   +12 more
wiley   +1 more source

Lysine l ‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation
ABSTRACT Lysine L‐lactylation (K L‐la ) is a newly identified metabolite‐derived post‐translational modification that directly bridges cellular metabolic states to chromatin regulation and protein function. Mounting evidence shows that K L‐la
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
openaire   +3 more sources

Lactate and Lactylation in Sepsis: A Comprehensive Review [PDF]

Sijia Liu,1,2,* Ting Yang,1,2,* Qingsong Jiang,1,2 Liang Zhang,1,2 Xinhui Shi,1,2 Xin Liu,3 Xiaoli Li1,2 1Department of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing, People’s Republic of China; 2Key Laboratory for ...
Liu X, Li X, Jiang Q, Liu S, Zhang L, Yang T, Shi X   +6 more
core  

Table4_Comprehensive analysis of lysine lactylation in Frankliniella occidentalis.XLSX

, 2022
Western flower thrips (Frankliniella occidentalis) are among the most important pests globally that transmit destructive plant viruses and infest multiple commercial crops.
Lili Shen (554603), Dongyang Liu (2891114), Lianqiang Jiang (13166610), Jinguang Yang (6440177), Fenglong Wang (1317603), Ying Li (38224), Pu Miao (12886949), Yujie Wang (308942), Liyun Song (4961476), Dong An (588806)   +9 more
core   +1 more source

Tip60‐Mediated USP22 Lactylation Drives Glutamine Metabolic Reprogramming via SLC25A5 in TNBC

Advanced Science, EarlyView.
Tip60‐mediated USP22 K134 lactylation, stabilizing SLC25A5 to enhance glutamine metabolism and α‐KG secretion. The secreted α‐KG drives GPR91‐dependent M2 macrophage polarization, promoting triple‐negative breast cancer progression. Targeting this axis synergizes with CB‐839, offering a promising therapeutic strategy for TNBC.
Fang Zhen, Hongyi Wang, Ningzhi Zhang, Le Wang, Huiyuan Tian, Luxi Kang, Zhanpeng Liu, Jing Hu   +7 more
wiley   +1 more source

Lactylation: A novel metabolic–epigenetic link in pancreatic cancer

Lactylation, a recently discovered post-translational modification, represents a crucial nexus between cellular metabolism and epigenetic regulation.
Dongmei Li, Xinyue Jiang, Linna Wei, Dengwang Chen, Zudi Meng   +4 more
core   +1 more source

Table2_Comprehensive analysis of lysine lactylation in Frankliniella occidentalis.XLSX

, 2022
Western flower thrips (Frankliniella occidentalis) are among the most important pests globally that transmit destructive plant viruses and infest multiple commercial crops.
Lili Shen (554603), Dongyang Liu (2891114), Lianqiang Jiang (13166610), Jinguang Yang (6440177), Fenglong Wang (1317603), Ying Li (38224), Pu Miao (12886949), Yujie Wang (308942), Liyun Song (4961476), Dong An (588806)   +9 more
core   +1 more source

DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs

Advanced Science, EarlyView.
p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Yunpeng Lv, Feng Wu, Xiongjie Liang, Chong Liu, Wenhui Guo, Kejian Zhang, Jiawen Niu, Wenjie Jiang, Hongjian Xu, Anlong Jiang, Yang Zheng, Enming Yu, Xintao Wang, Jinglong Yan, Jingjun Xia, Chengchao Song   +15 more
wiley   +1 more source

Histone H3 lysine 18 lactylation attenuates neuroinflammation and neurological damage by regulating microglial plxnb2 after ischemic stroke

Microglia are major resident immune cells in the central nervous system and are actively involved in the pathogenesis of ischemic stroke. Histone lactylation confers macrophage homeostatic gene expressions and regulates physiological and immune-related ...
Lingling Yu, Minjie Xie, Yao Wang, Zhou Zhu, Yuan Xu, Yongkang Fang, Linyu Feng, Ping Li, Na Jiang, Suiqiang Zhu, Guini Song, Wei Wang, Li Xu   +12 more
core   +1 more source

Lactylation of HSC70 Impairs Chaperone‐Mediated Autophagy to Promote Pyrin Inflammasome‐Dependent PANoptosis in Macrophages During Sepsis

Advanced Science, EarlyView.
In sepsis, lactate accumulation drives HSC70 K561 lactylation, which impairs chaperone‐mediated autophagy and blocks CUX1 degradation. Accumulated CUX1 transcriptionally upregulates Pyrin, triggering PANoptosis in macrophages and exacerbating inflammatory storm and organ injury.
Ying Chen, Yan Zhang, Pei Wang, Jiamin Ma, Xinru Zhao, Yi Li, Zhenghao Deng, Xueqing Meng, Jiali Zhu, Liangfang Yao, Jinbao Li   +10 more
wiley   +1 more source