Results 81 to 90 of about 119,118 (204)

Delactylation of the tumor suppressor ARHGDIB drives metastasis and chemoresistance in bladder cancer

Cell Reports
Summary: Emerging evidence has highlighted lactylation as a critical link between metabolism and tumor progression. Through integrative lactylome and proteome profiling, we delineate the global landscape of protein lysine lactylation in bladder cancer ...
Guanghui Xu, Yuqin Li, Shan Peng, Wei Zhao, Tianlei Xie, Minghao Zheng, Zhigang Wu, Yongming Deng, Yao Fu, Zhongqing Zhang, Xuyu Zhang, Yijing Chen, Jingyan Shi, Wei Chen, Meng Ding, Yihua Zhou, Wenli Diao, Hongqian Guo, Junlong Zhuang   +18 more
doaj   +1 more source

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source

Global profiling of protein lactylome in porcine granulosa cells

Journal of Ovarian Research
Background In mammals, granulosa cells (GCs) use glycolysis as the main energy source for oocyte development. Lactate, the end product of glycolysis, covalently binds lysine.
Shuhao Fan, Ren Zhou, Haoyu Wen, Haibo Ye, Shuya Ma, Yu Bu, Peihuan Wang, Xianrui Zheng, Yueyun Ding, Zongjun Yin, Xiaodong Zhang   +10 more
doaj   +1 more source

HADHA K406 Lactylation Regulates Metabolic Reprogramming and Suppresses Immune Responses in Gastric Cancer

Advanced Science, EarlyView.
HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng, Qinlian Jiao, Jiankang Zhu, Yidan Ren, Xiaoyu Teng, Xin Su, Zigan Li, Yuxuan Cai, Xiaoyan Liu, Yunshan Wang, Guangyong Zhang   +10 more
wiley   +1 more source

Lactylation in Tumor Immune Escape and Immunotherapy: Multifaceted Functions and Therapeutic Strategies

Research
Since its initial identification in 2019, lactylation has emerged as a critical posttranslation modification, attracting substantial research interest due to its diverse roles in biological processes.
Qing Li, Runkang Zhao, Yang Shen, Dandan Guo, Lvdan Deng, Rongbing Cai, Zhijun Shen, Zhao Xie, Na Hang, Sentao Fu, Dehuan Zhang, Yihang Xu, Zhao Huang, Bufu Tang, Ling Wang   +14 more
doaj   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Table7_Comprehensive analysis of lysine lactylation in Frankliniella occidentalis.XLSX

, 2022
Western flower thrips (Frankliniella occidentalis) are among the most important pests globally that transmit destructive plant viruses and infest multiple commercial crops.
Lili Shen (554603), Dongyang Liu (2891114), Lianqiang Jiang (13166610), Jinguang Yang (6440177), Fenglong Wang (1317603), Ying Li (38224), Pu Miao (12886949), Yujie Wang (308942), Liyun Song (4961476), Dong An (588806)   +9 more
core   +1 more source

Pyruvate Kinase M2‐Mediated H3K9 Lactylation and XBP1 Signaling Positive Feedback Loop Facilitates CD4+ T Cell Spinal Recruitment and Central Sensitization in Rheumatoid Arthritis

Advanced Science, EarlyView.
In collagen‐induced arthritis (CIA) mice, increased CD4+ T cell accumulation in the spinal dorsal horn induces pain hypersensitivity. Mechanistically, PKM2‐mediated H3K9 lactylation and XBP1 signaling positive feedback loop facilitates CD4+ T cell spinal migration and induces central sensitization‐like behaviors in CIA mice.
Yuepeng Jiang, Xiaoxuan Zhao, Xiao Ma, Mengjia Zheng, Junjun Wen, Yujie Li, Yue Wu, Yun Zhang, Jie Yu, Charles R. Ashby Jr, Chengping Wen   +10 more
wiley   +1 more source

Macrophage TRIM21 lactylation exacerbates infection-induced orchitis through enhancing STAT1-mediated CXCL9 and CXCL10 production

Frontiers in Immunology
IntroductionInfection-induced orchitis, a leading cause of acquired male infertility affecting 8%–12% of couples globally, is driven by unresolved inflammatory responses following bacterial infection.MethodsWe employed uropathogenic Escherichia coli ...
Wenjing Tang, Wenjing Tang, Wenjie Chen, Na Li, Wei Li, Zhigang Lei, Wenhui Sun, Xuan Xie, Yihong Jiang, Ying Chen, Lei Xu, Jifeng Zhu, Yalin Li, Jiahao Sha, Yang Dai, Sha Zhou, Xiaojun Chen, Chuan Su   +17 more
doaj   +1 more source

Table9_Comprehensive analysis of lysine lactylation in Frankliniella occidentalis.XLSX

, 2022
Western flower thrips (Frankliniella occidentalis) are among the most important pests globally that transmit destructive plant viruses and infest multiple commercial crops.
Lili Shen (554603), Dongyang Liu (2891114), Lianqiang Jiang (13166610), Jinguang Yang (6440177), Fenglong Wang (1317603), Ying Li (38224), Pu Miao (12886949), Yujie Wang (308942), Liyun Song (4961476), Dong An (588806)   +9 more
core   +1 more source