Results 71 to 80 of about 119,118 (204)
Advanced Science, EarlyView.Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong +13 more
wiley +1 more source
Nature Communicationsp53 is crucial for cellular functions and disease mechanisms, yet effective clinical strategies targeting it remain challenging. Lactylation has emerged as a key factor in understanding disease pathology and offering therapeutic options.
Huashan Liu +9 more
doaj +1 more source
, 2021 Lysine lactylation has been recognized as a novel post-translational modification occurring on histones. However, lactylation in non-histone proteins, especially in proteins of early branching organisms, is not well understood.
Tiandong Guan (11561926) +7 more
core +1 more source
CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells
Advanced Science, EarlyView.AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu +6 more
wiley +1 more source
Lactylation in digestive system tumors: from mechanisms to therapeutic target
Frontiers in OncologyLactylation, a recently identified epigenetic modification derived from lactate metabolism, has emerged as a key regulator linking cellular metabolic states to chromatin remodeling and gene transcription.
Jun Wei +5 more
doaj +1 more source
Proanthocyanidins Ameliorate LPS-Inhibited Osteogenesis of PDLSCs by Restoring Lysine Lactylation. [PDF]
Int J Mol SciPeriodontitis is a bacteria-induced inflammatory disease characterized by the progressive destruction of periodontal supporting tissues. Periodontal ligament stem cells (PDLSCs) are capable of differentiating into osteoblasts, which is an important stem cell source for endogenous periodontal tissue regeneration. Lysine lactylation (Kla) is a novel post-
Wu Y +9 more
europepmc +3 more sources
, 2021 Lysine lactylation has been recognized as a novel post-translational modification occurring on histones. However, lactylation in non-histone proteins, especially in proteins of early branching organisms, is not well understood.
Tiandong Guan (11561926) +7 more
core +1 more source
Lactate Signal: Modulator of Cellular Energy Production and Anabolism
Advanced Science, EarlyView.Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley +1 more source
, 2021 Lysine lactylation has been recognized as a novel post-translational modification occurring on histones. However, lactylation in non-histone proteins, especially in proteins of early branching organisms, is not well understood.
Tiandong Guan (11561926) +7 more
core +1 more source
Advanced Science, EarlyView.A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao +10 more
wiley +1 more source