Results 111 to 120 of about 119,118 (204)

RHOA lactylation at oncogenic hotspots promotes oncogenic activity and protein stabilization

Molecular Cancer
Background Aberrant RHOA activation drives tumor progression, yet regulatory mechanisms beyond genetic mutations remain poorly defined. Lactylation, a lactate-derived post-translational modification, links metabolic reprogramming to oncogenesis, but its ...
Chenglong Ma, Ruocen Liao, Xingyu Chen, Qianhua Cao, Xinyue Deng, Zhijun Dai, Chenfang Dong   +6 more
doaj   +1 more source

Lactylation Remodels Tumorigenesis, Immune Microenvironment, and Therapeutic Response

Current Issues in Molecular Biology
Lysine lactylation (Kla) is a lactate-driven post-translational modification that covalently links lactyl groups to lysine residues, directly coupling cellular metabolic states to gene expression regulation and protein functional remodeling.
Yufei Liu, Yutong Zhou, Huiwen Xue, Ruiru Xu, Yujiao Liu   +4 more
doaj   +1 more source

Metabolism meets inflammation: lactate and lactylation in inflammatory pathogenesis

Once regarded primarily as a glycolytic by-product, lactate is increasingly recognized as an active signaling metabolite involved in a broad spectrum of diseases.
Wei Qiu, Fuchun Fang, Xin Huang, Yaqiao Zhu, Ruiming Guo   +4 more
core   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Lactate Transferase Function of Alanyl-transfer t-RNA Synthetase and Its Relationship With Exercise

Shengwu huaxue yu shengwu wuli jinzhan
Lactylation (Kla), a protein post-translational modification characterized by the covalent conjugation of lactyl groups to lysine residues in proteins, is widely present in living organisms.
SUN Ying-Ying, XING Zheng, LI Feng-Yi, ZHANG Jing   +3 more
doaj   +1 more source

APP lysine 612 lactylation ameliorates amyloid pathology and memory decline in Alzheimer’s disease

Posttranslational modification (PTM) of the amyloid precursor protein (APP) plays a critical role in Alzheimer’s disease (AD). Recent evidence reveals that lactylation modification, as a novel PTM, is implicated in the occurrence and development of AD ...
Xiuyu Shi, Qiuyun Tian, Jiaojiao Wang, Lei Xia, Junjie Li, Mulan Chen, Bin Wu, Boqing Xu, Xin Tian, Lilin Yi, Yayan Pang, Zhifang Dong, Yehong Du, Na Tian, Weihong Song, Qian Xiao, Yuhan Tao, Wenting He, Yepeng Fan   +18 more
core   +1 more source

Warburg redefined: Metabolites, mitochondria and macrophages in immune regulation

The Journal of Physiology, EarlyView.
Abstract figure legend Following pro‐inflammatory stimulation, macrophages undergo Warburg‐like metabolic rewiring that extends more than increased glycolysis. The non‐canonical functions of glycolytic enzymes and lactate accumulation control macrophage immune responses through multiple signalling pathways (a).
Yukun Min, Órlaith C. Henry, Luke A. J. O'Neill   +2 more
wiley   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science
Cervical cancer remains a major global health burden, yet the molecular mechanisms driving its metabolic reprogramming are incompletely understood. Here, we identify heterogeneous nuclear ribonucleoprotein U (HNRNPU) as a novel non‐histone substrate of ...
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
doaj   +1 more source

Many Routes from Glycolysis to Histone PTMs. Nature “Matters Arising” response to: Zhang et al. Metabolic regulation of gene expression by histone lactylation. (2019) Nature. 574(7779), 575-580.

, 2020
Multiple histone post-translational modifications (PTMs) originate from small molecule metabolites (e.g. acetyl-lysine from acetyl-CoA) 1. As such, we read with interest the recent Nature paper from Zhang et al.
Paul Brookes, Chaitanya A. Kulkarni
core   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, Volume 13, Issue 61, 3 November 2026.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source