Results 121 to 130 of about 119,118 (204)

Investigating the Role of Lysine Lactylation during Human Cytomegalovirus Infection

Post-translational modifications (PTMs) regulate diverse cellular pathways through modulation of protein function. Previous studies have shown that certain PTMs are derived from crucial cellular metabolites, and dysregulation of these PTMs contributes ...
Merengwa, Victoria
core  

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, Volume 13, Issue 61, 3 November 2026.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Lactylation as a metabolic-epigenetic switch in cancer: dual roles in cell death resistance and therapeutic vulnerability

Cell Death and Disease
Protein lactylation emerges as a pivotal metabolic rheostat, translating microenvironmental lactate flux into stable programs that orchestrate cancer treatment resistance. This review synthesizes recent advances under the framework of “Lactylation Switch
Chengjiao Yang, Ruici Yang, Binbin Zheng, Hongxiao Jiang, Xianteng Wang, Weiren Huang   +5 more
doaj   +1 more source

Lactylation-stabilized NOL6 promotes colorectal cancer progression via STAMBP-mediated YY1 deubiquitination and c-Myc transcription upregulation

Cell Reports
Summary: Colorectal cancer (CRC) represents a significant menace to human health, but its molecular pathogenesis remains unclear. Herein, we explored the functional role of spindle and nucleolar protein 6 (NOL6) in CRC progression.
Hao Zhang, Ye Han, Jiaqi Wang, Chunlin Wang, Zewen Chang, Jun Xiang, Hanqing Hu, Ziming Yuan, Nana Zhang, Yuliuming Wang, Chenkai Zhang, Yunxiao Liu, Chengwei Wu, Jian Ma, Xianli Zhou, Guiyu Wang   +15 more
doaj   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, Volume 13, Issue 61, 3 November 2026.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, Volume 13, Issue 61, 3 November 2026.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Lactylproteome analysis indicates histone H4K12 lactylation as a novel biomarker in triple-negative breast cancer

Frontiers in Endocrinology
ObjectiveThe established link between posttranslational modifications of histone and non-histone lysine (K) residues in cell metabolism, and their role in cancer progression, is well-documented.
Zhaolei Cui, Yanhong Li, Yingying Lin, Chaoqiang Zheng, Lingqing Luo, Dan Hu, Yan Chen, Zhenzhou Xiao, Yang Sun   +8 more
doaj   +1 more source

Histone H3 Lysine 18 Lactylation Promotes Cardiac Hypertrophy Through Activating GATA Binding Protein 4 Signaling

Histone lactylation, particularly histone H3 lysine 18 lactylation (H3K18la), modulates gene expression profile in diverse cellular processes, which has emerged as a critical factor in cardiovascular disease pathogenesis.
Yani Wang, Deyu Fu, Haidong Guo, Zixian Liu, Da Li, Liang Hu, Mingzhu Wang, Yongbo Ma, Yuan Lin   +8 more
core   +1 more source

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, Volume 13, Issue 61, 3 November 2026.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source

Functional impacts of lactylation in Hypoxia‒primed mesenchymal stromal cells [PDF]

Hypoxic culture (1–5% O2) significantly enhances the biological activity and therapeutic potential of mesenchymal stromal cells (MSCs) by activating the HIF-1α signaling pathway.
Qixing Tang, Jie Liu, Fanyi Zhao
core   +1 more source