Results 141 to 150 of about 119,118 (204)

Research progress on protein lactylation in female reproductive disease: molecular mechanisms, functions, and therapeutic implications

Frontiers in Pharmacology
Female reproductive health depends on precisely coordinated metabolic, hormonal, immune, and epigenetic networks. Lactylation is a lactate-derived lysine post-translational modification that provides a direct mechanism by which glycolytic metabolism ...
Xiaoyang Shen, Xiaoyang Shen, Xiaoyang Shen, Yan Chen, Yan Chen, Yan Chen, Hongxia Deng, Hongxia Deng, Nannan Zhang, Nannan Zhang, Liangzhi Xu, Liangzhi Xu, Liangzhi Xu   +12 more
doaj   +1 more source

Lactylation Modification and Esophageal Cancer: Research Progress From Hypoxia‐Induced Metabolic Reprogramming to Immune Escape

Esophageal cancer is a common malignancy of the digestive tract, marked by aggressive invasion, unfavorable prognosis, and limited responsiveness to existing therapeutic strategies.
Weizhuang Sun, Xiaowei Liu, Yang Wang, Changyong Li   +3 more
core   +1 more source

Atherosclerosis: From Pathogenesis to Therapeutic Interventions

MedComm, Volume 7, Issue 11, November 2026.
The diagram outlines the core mechanisms driving atherosclerosis, including endothelial dysfunction, inflammatory responses, phenotypic switching of smooth muscle cells, and the gut–vascular axis. It also presents the corresponding therapeutic approaches now under development, such as gene therapies, immunotherapies, and nanotechnology platforms ...
Enge Zhou, Chenxi Zhan, Yuting Li, Yi Zeng, Renfei Luo, Xin Ouyang, Shixing Liu, Renqiang Yang, Nianlong Yan, Long Jiang   +9 more
wiley   +1 more source

Lactylation omics of rabbit rotator cuff tear reveals differentially modified proteins and metabolic relating therapy targets

Frontiers in Medicine
Proteins exert biological functions not only depending on abundance but also on regulation. Lactylation, a novel post-translational modification, can mediate metabolic reprogramming and epigenetic regulation, playing a crucial role in signal transduction,
Tong Pan, Tong Pan, Tong Pan, Zhenlong Liu, Zhenlong Liu, Zhenlong Liu   +5 more
doaj   +1 more source

Protein Lactylation in Cancer: From Mechanisms to Therapy

MedComm, Volume 7, Issue 11, November 2026.
Increased glycolysis and lactate accumulation promote histone and nonhistone protein lactylation, linking tumor metabolic reprogramming to treatment adaptation. Lactylation enhances DNA repair, suppresses antitumor immunity, strengthens antioxidant defenses, and facilitates cell‐cycle checkpoint escape, collectively promoting resistance to chemotherapy,
Wentian Huang, Ping Hu, Shun Wang, Xide Zhang, Ziran Ye, Shengqiang Chen, Fu Gao, Yuanyuan Chen, Yanyong Yang   +8 more
wiley   +1 more source

Regulatory T Cells in Health and Disease

MedComm, Volume 7, Issue 11, November 2026.
Regulatory T cells (Tregs) arise through distinct developmental pathways and adapt to specialized tissue niches to maintain immune tolerance, barrier integrity, and metabolic homeostasis. In disease, Tregs undergo context‐dependent changes, ranging from functional insufficiency and lineage instability in autoimmune, inflammatory, cardiovascular, and ...
Mingyi Li, Si Zhang, Tangchun Wu, Tingting Tang, Xiang Cheng   +4 more
wiley   +1 more source

Histone Modifications at the Intersection of Aging, Neuroinflammation and Metabolism in Alzheimer's Disease

Aging Cell, Volume 25, Issue 11, November 2026.
This review examines how histone modifications integrate aging, metabolic dysfunction and neuroinflammation to shape persistent, cell‐type‐specific chromatin states in Alzheimer's disease. By distinguishing causal regulation from association through perturbation, persistence and reversibility, it highlights metabolic–epigenetic feedback loops and ...
Junyi Liang, Huawen Cao, Xiumin Ren, Nan Sha, Xueqing Han, Ling Jiang, Bin Liu, Weiming Zhao   +7 more
wiley   +1 more source

H3K18 Lactylation in Degenerated Nucleus Pulposus Cells Suppresses CD248 Through Transcriptional and Post‐Translational Modifications to Promote Apoptosis and Extracellular Matrix Degradation

Aging Cell, Volume 25, Issue 11, November 2026.
The high lactate levels in degenerated intervertebral discs promote lactylation of NP cells. H3K18la inhibits the synthesis of CD248 mRNA by recruiting SMARCA5 and promotes the protein degradation of CD248 through the ubiquitin–proteasome pathway, thereby inducing apoptosis of NP cells and degradation of ECM.
Yiming Ma, Tuo Shao, Qichang Gao, Jiaao Gu, Wenbo Zhan, Shuning Han, Song Li, Zhange Yu   +7 more
wiley   +1 more source

Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation

Summary: Macrophage activation is a hallmark of atherosclerosis, accompanied by a switch in core metabolism from oxidative phosphorylation to glycolysis.
Longbin Zheng, Minghong Chen, Xian He, Fuhao Liu, Yongfeng Shao, Jiao Min, Hong Jiang, Xuesong Li, Yongkang Tan, Hongshan Chen, Xiang Chen, Mengdie Dong, Quanwen Yin, Yunjia Zhang   +13 more
core   +1 more source

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, Volume 59, Issue 11, November 2026.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source