Results 151 to 160 of about 119,118 (204)

Therapeutic potential of microglial SMEK1 in regulating H3K9 lactylation in cerebral ischemia-reperfusion

Acute ischemic stroke (AIS) triggers immune responses and neuroinflammation, contributing to brain injury. Histone lactylation, a metabolic stress-related histone modification, plays a critical role in various diseases, but its involvement in cerebral ...
Heng Li, Shu-Li Wei, Liang-Kang Li, Chun-Lin Yang, Qi-Ji Liu, Wei-Yue Si, Rui-Sheng Duan, Yang Zhou, Ruo-Nan Duan, Jing Dong, Peng Zhang, Tong Du   +11 more
core   +1 more source

High Sugar Induced RCC2 Lactylation Drives Breast Cancer Tumorigenicity Through Upregulating MAD2L1

Lactylation is a novel post‐translational modification mediated by lactate, widely present in the lysine residues of both histone and non‐histone proteins. However, the specific regulatory mechanisms and downstream target proteins remain unclear. Herein,
Bowen Zheng, Wenfang Zheng, Lin Fang, Xuehui Wang, Seng Zhong, Diya Liu, Danrong Ye, Baian Zhou, Yunhao Pan, Fengyuan Qian, Yuying Wang, Bolin Yu   +11 more
core   +1 more source

Lysine lactylation in glioma: from metabolic stress to epigenetic remodeling and therapeutic resistance. [PDF]

Front Cell Dev Biol
Hu X, Yang L, Hu Y, Cui H.
europepmc   +1 more source

Lysine Lactylation Modifies Cryab-Hspa1b Interactions and Prevents MAPK Signaling to Slow Diabetic Cardiomyopathy Progression. [PDF]

Diabetes
Ma D, Liang X, Jing H, Liu X, Liu P, Cai W, Zhong X, Li X, Dong S, Tian Y, Wei C.   +10 more
europepmc   +1 more source

Global Profiling of Protein Lysine Lactylation in Mouse Cardiac Hypertrophy: A Lactylome Analysis. [PDF]

J Cardiovasc Dev Dis
Zhu W, Guo S, Yang Y, Dong Y, Liu C, Chen C.   +5 more
europepmc   +1 more source

Identification of protein lysine lactylation and potential targets in esophageal squamous cell carcinoma. [PDF]

Transl Cancer Res
Zhang H, Yan X, Xi L, Chen S, Shang Q, Chen LQ, Wang WP.   +6 more
europepmc   +1 more source

Training PBertKla on an Integrated Multi-Source Dataset with a Machine-Learning Layer for Lysine Lactylation Site Prediction. [PDF]

Int J Mol Sci
Jin SB, Park J, Lee SD, Han JH, Myung SH, Park K, Yun J.   +6 more
europepmc   +1 more source

Lysine lactylation-mediated post-translational modification: Molecular mechanisms and therapeutic target exploration in tumour drug resistance. [PDF]

Clin Transl Med
Li J, Shang Y, Wu H, Yang S, Zuo M, Zhao H.   +5 more
europepmc   +1 more source

Beyond metabolic waste: lysine lactylation and its potential roles in cancer progression and cell fate determination. [PDF]

Cell Oncol (Dordr), 2023
Wang JH, Mao L, Wang J, Zhang X, Wu M, Wen Q, Yu SC.   +6 more
europepmc   +1 more source

Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma. [PDF]

Sci Rep, 2023
Wu Q, Li X, Long M, Xie X, Liu Q.
europepmc   +1 more source