Results 171 to 180 of about 119,118 (204)

Global analysis of protein lysine lactylation profiles in the marine bacterium <i>Photobacterium damselae</i> subsp. <i>damselae</i>. [PDF]

Front Microbiol
Yu Y, Liu H, Wang C, Wang Y, Rong X, Liao M, Li B, Yi X, Zhang Z.   +8 more
europepmc   +1 more source

Comprehensive analysis of lysine lactylation and its potential biological significance in clear cell renal cell carcinoma. [PDF]

Eur J Med Res
Wan B, Huang Y, Gong B, Zeng Y, Lv C.
europepmc   +1 more source

HBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription. [PDF]

Nat Commun
Niu Z, Chen C, Wang S, Lu C, Wu Z, Wang A, Mo J, Zhang J, Han Y, Yuan Y, Zhang Y, Zang Y, He C, Bai X, Tian S, Zhai G, Wu X, Zhang K.   +17 more
europepmc   +1 more source

Identification of lysine lactylation (kla)-related lncRNA signatures using XGBoost to predict prognosis and immune microenvironment in breast cancer patients. [PDF]

Sci Rep
Lin F, Li H, Liu H, Shen J, Zheng L, Huang S, Chen Y.   +6 more
europepmc   +1 more source

3.4 The Lysine L-Lactylation Pathway: Biochemistry, Epigenetics and Pathophysiology

Molecular & Cellular Proteomics
openaire   +1 more source

Biochemistry and Regulation of Histone Lysine l-Lactylation

Nature Reviews Molecular Cell Biology
Histone L-lactylation is a newly identified, metabolism-linked short-chain Lys acylation. Mounting evidence indicates that Lys L-lactylation has key roles in transcription regulation and many other cellular processes and is associated with diverse pathophysiological changes.
Philip A Cole, Hening Lin, Xinlei Sheng
exaly   +3 more sources

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Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells

Journal of Proteome Research, 2023
Among the various cell types that constitute the liver, Kupffer cells (KCs) are responsible for the elimination of gut-derived foreign products. Protein lysine acetylation (Kac) and lactylation (Kla) are dynamic and reversible post-translational modifications, and various global acylome studies have been conducted for liver and liver-derived cells ...
Sangkyu Lee, Hyunchae Sim, Jong-Sup Bae
exaly   +3 more sources

Current and Future Perspectives of Lysine Lactylation in Cancer

Trends in Cell Biology
Lactate, a glycolytic intermediate, has a crucial role in cancer metabolism and microenvironment remodeling. Recently, researchers found that lactate mediates lysine lactylation, a novel protein post-translational modification (PTM). Here, we summarize the mechanism and role of lysine lactylation in cancer, and discuss the potential of targeting lysine
Kui Wang, Lixia Dong
exaly   +3 more sources

Lysine Lactylation in the Regulation of Tumor Biology

Trends in Endocrinology and Metabolism
Lysine lactylation (Kla), a newly discovered post-translational modification (PTM) of lysine residues, is progressively revealing its crucial role in tumor biology. A growing body of evidence supports its capacity of transcriptional regulation through histone modification and modulation of non-histone protein function.
Zijian Yang, Qiang Gao, Yingqi Zheng
exaly   +3 more sources

Regulation of Newly Identified Lysine Lactylation in Cancer

Cancer Letters
Metabolic reprogramming is a typical hallmark of cancer. Enhanced glycolysis in tumor cells leads to the accumulation of lactate, which is traditionally considered metabolic waste. With the development of high-resolution liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS), the lactate-derived, lysine lactylation(Kla), has been ...
Zhiyao Fan, Chaoyu Pang
exaly   +3 more sources