Results 181 to 190 of about 119,118 (204)
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Expanding the Genetic Code for Site-Specific Lysine Lactylation
Nature Reviews Molecular Cell BiologyZhi Zong
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Emerging roles of lysine lactyltransferases and lactylation
Nature Cell BiologyGiven its various roles in cellular functions, lactate is no longer considered a waste product of metabolism and lactate sensing is a pivotal step in the transduction of lactate signals. Lysine lactylation is a recently identified post-translational modification that serves as an intracellular mechanism of lactate sensing and transfer.
Zhi Zong +4 more
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Subcellular Proteomic Mapping of Lysine Lactylation
Journal of the American Society for Mass SpectrometryProtein lactylation is a novel post-translational modification (PTM) involved in many important physiological processes such as macrophage polarization, immune regulation, and tumor cell growth. However, traditional methodologies for studying lactylation have predominantly relied on peptide enrichment from whole-cell lysates, which tend to favor the ...
Qiuyu Bao +6 more
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Comprehensive Analysis of Lysine Lactylation in Rice (Oryza sativa) Grains
Journal of Agricultural and Food Chemistry, 2021Protein lysine lactylation is a new post-translational modification (PTM) prevalently found in fungi and mammalian cells that directly stimulates gene transcription and regulates the glycolytic flux. However, lysine lactylation sites and regulations remain largely unexplored, especially in cereal crops.
Xiaoxi Meng +3 more
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ACSF2 And Lysine Lactylation Contribute to Renal Tubule Injury in Diabetes
DiabetologiaLactate accumulation is reported to be a biomarker for diabetic nephropathy progression. Lactate drives lysine lactylation, a newly discovered post-translational modification that is involved in the pathogenesis of cancers and metabolic and inflammatory disease.
Dongwei Liu, Zhangsuo Liu, Shaokang Pan
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The growing landscape of lysine lactylation links to immunosuppressive microenvironment
European Journal of PharmacologyLysine lactylation (Kla) has emerged as an epigenetic-metabolic regulatory mechanism linking post-translational modification (PTM) to immunosuppressive TME formation. Evidence supports its complex role in TME by modulating immune state transitions and augmenting tumor malignancy.
Chao, Huang, Wei, Zhu, Li, Sun
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Lysine Lactylation-Based Insight to Understanding the Characterization of Cervical Cancer
Biochimica Et Biophysica Acta - Molecular Basis of DiseaseLysine lactylation (Kla), a recently discovered post-translational modification (PTM), is not only present in histone proteins but also widely distributed among non-histone proteins in tumor cells and immunocytes. However, the precise characterization and functional implications of these non-histone Kla proteins remain to be explored.
Jianji Zhang, Congcong Lu
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Histone Lysine Lactylation Regulates Gene Expression
Cancer Discovery, 2019Abstract A previously unknown histone modification, lysine lactylation, was found in mouse and human cells.
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Lactate and lysine lactylation: Emerging drivers shaping tumor immune evasion
International ImmunopharmacologyAbnormal lactate metabolism and lysine lactylation (Kla) have emerged as critical factors driving tumor immune evasion through dual mechanisms of tumor metabolic reprogramming and epigenetic regulation. Tumor cells produce lactate through multiple metabolic pathways, which is then exported via monocarboxylate transporters to accumulate in the tumor ...
Shiying, Fan +11 more
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