Results 191 to 200 of about 119,118 (204)

Multifaceted Roles of Histone Lysine Lactylation in Meiotic Gene Dynamics and Recombination

Abstract Male germ cells, which are responsible for producing millions of genetically diverse sperm through meiosis in the testis, rely on lactate as their central energy metabolite. Recent study has revealed that lactate induces epigenetic modification in cells through histone lactylation, a post-translational modification involving ...
Xiaoyu, Zhang, Yan, Liu, Ning, Wang
openaire   +2 more sources

Lysine Lactylation: Dynamic Regulation in the Tumor Microenvironment and Clinical Translational Prospects

BioFactors
ABSTRACT This review systematically explores the dynamic regulatory roles of lysine lactylation (Kla) in the tumor microenvironment (TME) and its clinical translational potential. As an emerging post‐translational modification, Kla modifies histones and non‐histone proteins via lactate generated by the Warburg ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Ruowei Sun, Qian Zhang, Gokhan Zengin, Meng‐Yao Li   +6 more
openaire   +2 more sources

Positive Feedback Regulation of Microglial Glucose Metabolism by Histone H4 Lysine 12 Lactylation in Alzheimer’s Disease

Cell Metabolism, 2022
Zengqiang Yuan, Ju Gao, Lin He
exaly  

AGAE-Layzer: An in-silico tool for predicting lysine lactylation sites

Lysine lactylation (Kla) is a recently discovered post-translational modification with crucial regulatory roles in cellular metabolism, gene expression, and disease. Accurate identification of lactylation sites is essential for understanding their biological functions. While experimental methods are accurate, they are also time-consuming and expensive,
Amr Galal Abdelraheem Ibrahim, Edson Aparecido Adrano   +1 more
openaire   +1 more source

Comprehensive Analysis of Lysine Lactylation in Rice (Oryza sativa) Grains

Journal of Agricultural and Food Chemistry, 2021
Xiaoxi Meng, Tingcai Yan
exaly  

Global Profiling of Protein Lysine Lactylation and Potential Target Modified Protein Analysis in Hepatocellular Carcinoma

Proteomics, 2023
Han Hong
exaly  

REAGENTS AND METHODS FOR DETECTING PROTEIN LYSINE LACTYLATION

2022
ZHAO YINGMING, ZHANG DI, DAI LUNZHI
openaire   +2 more sources

Systematic Analysis of Lysine Lactylation in the Plant Fungal Pathogen Botrytis cinerea

Frontiers in Microbiology, 2020
Wen-Xing Liang, Ning Zhang, Mingming Gao
exaly  

Comprehensive Observation of Histone Lysine Lactylation During Gametogenesis of Drosophila Melanogaster

Developmental Dynamics
Daisuke Saito, Kenji Miyado, Yoshiki Hayashi   +2 more
exaly  

Lysine Lactylation: Regulatory Mechanisms, Role in Health and Disease, and Its Therapeutic Potential

Drug Discovery Today
Xijuan Jiang, Yang Lin, Huayuan Wei
exaly