Results 131 to 140 of about 119,118 (204)

BDH1 Attenuates Macrophage Foam Cell Formation and Inflammation in Atherosclerosis Via Modulating Histone H3K9 Acylation Balance and Activating PPAR Signaling

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
In atherosclerotic lesions, BDH1 expression is downregulated in plaque macrophages. In ox‐LDL‐induced RAW264.7 macrophages, BDH1 overexpression maintains H3K9 acylation homeostasis by upregulating H3K9ac and downregulating H3K9bhb, thereby increasing cell viability, reducing lipid accumulation, decreasing TNF‐α, and increasing IL‐10.
Yu Wang, Yi Wang, Qinghong Liu, Mao Tian, Bin Wang, Qiang Lin, Shuiying Huang   +6 more
wiley   +1 more source

Lactylation: a metabolic–epigenetic driver in atherosclerosis pathogenesis and therapeutic targeting

Frontiers in Cardiovascular Medicine
Atherosclerosis (AS), a disease of large and medium-sized arteries, is a common cause of cardiovascular morbidity and mortality. Lactylation is a recently identified post-translational modification involving the addition of lactate-derived lactyl groups ...
Wenbo Lv, Wenbo Lv, Linxi Xie, Linxi Xie, Jintao Tao, Jintao Tao, Qingqi Xu, Qingqi Xu, Wenfeng Hu, Wenfeng Hu, Hao Xie, Hao Xie, Pin Lu, Pin Lu, Ying Xu, Ying Xu, Liang Huang   +16 more
doaj   +1 more source

Lactylation formation, gene regulation, biological functions, and clinical relevance

Lactate, as an end-product of glycolysis, has been considered as a metabolic waste that participates in a few physiological functions. Recently, a novel study by Zhao’s laboratory reported that lactate can serve as an epigenetic modification ...
Ying Li, Yongchao Zhao, Zhimei Qiu, Youyang Huang, Bei Shi, Xiaoyu Wei, Qing Guo   +6 more
core   +1 more source

SIRT7 Mediated‐PTEN Desuccinylation Drives Gastric Tumorigenesis by Activating PI3K/AKT Pathway

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
SIRT7 is upregulated in gastric cancer (GC). SIRT7‐mediated desuccinylation of PTEN at K322/K330 promotes its degradation, thereby activating the PI3K/AKT signaling pathway and ultimately driving GC progression. ABSTRACT SIRT7 is linked to cancer, yet its function in gastric cancer (GC) remains unclear.
Bingling Liao, Sheng Hu, Qilin Zhang, Qihua Xu, Tianning Tian   +4 more
wiley   +1 more source

The lactylation-immunosuppression network in cancer: driving a metabolic-epigenetic axis

Frontiers in Immunology
The accumulation of lactate in the tumor microenvironment (TME), driven by the Warburg effect, is closely associated with immunosuppression. Lactate can contribute to this process through lysine lactylation, a novel post-translational modification.
Jinfeng Ye, Yunliang Lu, Wansu Huang, Shan Huang, Shan Huang, Zhe Zhang, Zhe Zhang, Xiaoying Zhou, Xiaoying Zhou, Xue Xiao, Tingting Huang   +10 more
doaj   +1 more source

KAT2A Promotes the Progression of Renal Cell Carcinoma by Regulating the Succinylation of SERPINE2

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 11, November 2026.
ABSTRACT Epithelial‐mesenchymal transition (EMT) and angiogenesis are critical drivers of renal cell carcinoma (RCC) progression, yet their upstream regulatory mechanisms remain incompletely understood. This study aimed to investigate the role of KAT2A in RCC and elucidate the underlying molecular mechanism by which it promotes tumor progression.
Chang‐Cheng Liu, Xue‐Dong Li
wiley   +1 more source

Lactylation: a promising therapeutic target in ischemia-reperfusion injury management

Cell Death Discovery
Ischemia-reperfusion injury (IRI) is a critical condition that poses a significant threat to patient safety. The production of lactate increases during the process of IRI, and lactate serves as a crucial indicator for assessing the severity of such ...
Fei-xiang Wang, Guo Mu, Zi-hang Yu, Zu-an Shi, Xue-xin Li, Xin Fan, Ye Chen, Jun Zhou   +7 more
doaj   +1 more source

Protein lactylation of citrate synthase promotes the AKI-CKD transition by activating the NLRP3 inflammasome

Cell Reports
Summary: Interstitial renal inflammation contributes to the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). Recently, lactylation modification has emerged as a mechanism for mediating chronic organ damage.
Fang Yu, Yan Meng, Xiaoyue Wang, Jia Chen, Junling He, Xiangling Yi, Yani He, Kehong Chen   +7 more
doaj   +1 more source

Crosstalk between lactylation and other post-translational modifications in health and diseases

The inherent perception of lactate as the byproduct of glycolysis has been transformed by the discovery of lysine lactylation (Kla). Lactylation modification, a reversible and precise acylation, occurs on both histones and non-histone proteins and ...
Jimin Su, Wentao Qi, Bowen Li, Fu Yang, Xiangming He, Qinglin Li   +5 more
core   +1 more source

PRAME Augments K63‐Linked Ubiquitination and Stabilization of METTL3 to Promote Lung Adenocarcinoma Metastasis

MedComm, Volume 7, Issue 11, November 2026.
PRAME promotes lung adenocarcinoma metastasis by inducing K63‐linked ubiquitination of METTL3 at lysine 235, thereby enhancing METTL3 stability and m6A methyltransferase complex assembly. Elevated METTL3 activity increases m6A modification of TGFB2 mRNA, leading to activation of TGF‐β signaling and metastatic progression of lung adenocarcinoma (LUAD ...
Xia Yang, Xuemei Xu, Yaxuan Zhang, Jiamei Guo, Zhiyu Ye, Qiaorui Bai, Xiuqiao Yang, Shujun Liang, Xiang Dong, Xin Zhang, Jiyong Gu, Shuqin Dai, Hongchun Du, Meiwan Chen, Tianyu Tao, Hongyu Guan, Jueheng Wu, Han Tian, Junchao Cai, Mengfeng Li, Xu Li, Yi Yang   +21 more
wiley   +1 more source