Results 81 to 90 of about 2,589 (171)

The lactylation-immunosuppression network in cancer: driving a metabolic-epigenetic axis

Frontiers in Immunology
The accumulation of lactate in the tumor microenvironment (TME), driven by the Warburg effect, is closely associated with immunosuppression. Lactate can contribute to this process through lysine lactylation, a novel post-translational modification.
Jinfeng Ye, Yunliang Lu, Wansu Huang, Shan Huang, Shan Huang, Zhe Zhang, Zhe Zhang, Xiaoying Zhou, Xiaoying Zhou, Xue Xiao, Tingting Huang   +10 more
doaj   +1 more source

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source

Lactylation omics of rabbit rotator cuff tear reveals differentially modified proteins and metabolic relating therapy targets

Frontiers in Medicine
Proteins exert biological functions not only depending on abundance but also on regulation. Lactylation, a novel post-translational modification, can mediate metabolic reprogramming and epigenetic regulation, playing a crucial role in signal transduction,
Tong Pan, Tong Pan, Tong Pan, Zhenlong Liu, Zhenlong Liu, Zhenlong Liu   +5 more
doaj   +1 more source

The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities

MedComm, Volume 7, Issue 3, March 2026.
Diverse diseases converge on NLRP3. We depict a discovery‐to‐clinic track: high‐throughput/phenotypic screens, structure‐guided design, and modality innovation (allosteric inhibitors, interface blockers, degraders) deliver third‐generation, disease‐tailored NLRP3 control.
Chan Zou, Shilong Jiang, Hui Li, Kai Zhao, Dongshen Cao, Guoping Yang   +5 more
wiley   +1 more source

Histone H3 lysine 18 lactylation attenuates neuroinflammation and neurological damage by regulating microglial plxnb2 after ischemic stroke

Neurobiology of Disease
Microglia are major resident immune cells in the central nervous system and are actively involved in the pathogenesis of ischemic stroke. Histone lactylation confers macrophage homeostatic gene expressions and regulates physiological and immune-related ...
Ping Li, Yao Wang, Yuan Xu, Linyu Feng, Na Jiang, Yongkang Fang, Guini Song, Lingling Yu, Li Xu, Zhou Zhu, Suiqiang Zhu, Wei Wang, Minjie Xie   +12 more
doaj   +1 more source

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, Volume 2, Issue 1, Page 4-21, March 2026.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

Non-histone lactylation: unveiling its functional significance

Frontiers in Cell and Developmental Biology
Lactylation, a newly discovered protein posttranslational modification (PTM) in 2019, primarily occurs on lysine residues. Lactylation of histones was initially identified, and subsequent studies have increasingly demonstrated its widespread presence on ...
Pusong Shi, Yongjie Ma, Yongjie Ma, Yongjie Ma, Yongjie Ma, Yongjie Ma, Shaolu Zhang, Shaolu Zhang, Shaolu Zhang, Shaolu Zhang, Shaolu Zhang   +10 more
doaj   +1 more source

Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice

Aging Cell, Volume 25, Issue 3, March 2026.
The left panel shows cerebral lactate homeostasis in young mice. The middle panel displays accelerated ANLS rates due to FGF21 secretion in aging mice. The right panel demonstrates that lactate uptake and usage inhibition contribute to lactate extracellular accumulation, followed by HCA1‐mediated learning and memory decline in mice.
Keru Ji, Hongde Wei, Ruguang Wang, Yutong Wu, Chen Li, Hongchang Gao, Liangcai Zhao   +6 more
wiley   +1 more source

AARS1 and AARS2: From Protein Synthesis to Lactylation-Driven Oncogenesis

Biomolecules
Aminoacyl-tRNA synthetases (AARSs), traditionally recognized for their essential role in protein synthesis, are now emerging as critical players in cancer pathogenesis through translation-independent functions.
Lingyue Gao, Jihua Guo, Rong Jia
doaj   +1 more source

Histone lactylation bridges metabolic reprogramming and epigenetic rewiring in driving carcinogenesis: Oncometabolite fuels oncogenic transcription

Clinical and Translational Medicine
Heightened lactate production in cancer cells has been linked to various cellular mechanisms such as angiogenesis, hypoxia, macrophage polarisation and T‐cell dysfunction.
Yu Zhang, Hang Song, Meili Li, Peirong Lu   +3 more
doaj   +1 more source