Results 11 to 20 of about 94,143 (143)

Extensive comparison of protein sequence-based bioinformatics applications for predicting lysine succinylation sites: a comparative review

Biotechnology and Biotechnological Equipment
Lysine succinylation is a post-translational modification that occurs when a succinyl group bonds with a lysine residue and changes the polarity of lysine from positive to negative, causing significant changes in the structure and functioning of proteins.
Hussam Alsharif
exaly   +4 more sources

A Systematic Study of Lysine Succinylation in the Pathogenic Bacterium Vibrio harveyi in Aquatic Animals [PDF]

Molecules
Vibrio harveyi, a pathogenic vibrio, is ubiquitous and the most prevalent disease infecting tropical and subtropical mariculture animals in marine and estuarine environments.
Shuai Yang, Peng Zhou, Weijie Zhang, Yujia Zhang, Haiwei Guo, Yingzhu Wei, Xiaoxin Wen, Jichang Jian, Na Wang, Huanying Pang   +9 more
doaj   +3 more sources

Global Proteomic Analysis Reveals Widespread Lysine Succinylation in Rice Seedlings [PDF]

International Journal of Molecular Sciences, 2019
Lysine succinylation (Ksu) is a dynamic and reversible post-translational modification that plays an important role in many biological processes. Although recent research has analyzed Ksu plant proteomes, little is known about the scope and cellular ...
Kai Zhang, Guo-Liang Wang, Kai Zhang
exaly   +3 more sources

Comprehensive analysis of the lysine acetylome in Aeromonas hydrophila reveals cross-talk between lysine acetylation and succinylation in LuxS

Emerging Microbes and Infections, 2019
Lysine acetylation and succinylation are both prevalent protein post-translational modifications (PTMs) in bacteria species, whereas the effect of the cross-talk between both PTMs on bacterial biological function remains largely unknown.
Lina Sun, Zujie Yao, Zhuang Guo, Lishan Zhang, Yuqian Wang, Ranran Mao, Yuexu Lin, Yuying Fu, Xiangmin Lin   +8 more
doaj   +2 more sources

Systematic identification and comparative analysis of lysine succinylation between the green and white parts of chimeric leaves of Ananas comosus var. bracteatus [PDF]

BMC Genomics, 2020
Background Lysine succinylation, an important protein posttranslational modification (PTM), is widespread and conservative. The regulatory functions of succinylation in leaf color has been reported. The chimeric leaves of Ananas comosus var.
Meiqin Mao, Yanbin Xue, Yehua He, Xuzixing Zhou, Fatima Rafique, Hao Hu, Jiawen Liu, Lijun Feng, Wei Yang, Xi Li, Lingxia Sun, Zhuo Huang, Jun Ma   +12 more
doaj   +2 more sources

DLST Succinylation-Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma. [PDF]

Adv Sci (Weinh)
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Li X, Zhou P, Peng X, Liu Q, Zeng W, Wang R, Shen L, Peng J, Zhou Q, Yang L.   +9 more
europepmc   +2 more sources

A systematic identification of species-specific protein succinylation sites using joint element features information

International Journal of Nanomedicine, 2017
Md Mehedi Hasan,1 Mst Shamima Khatun,2 Md Nurul Haque Mollah,2 Cao Yong,3 Dianjing Guo1 1School of Life Sciences and the State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, New Territory, Hong Kong, People’s ...
Hasan MM, Khatun MS, Mollah MNH, Yong C, Guo D   +4 more
doaj   +1 more source

Succinyl-proteome profiling of Dendrobium officinale, an important traditional Chinese orchid herb, revealed involvement of succinylation in the glycolysis pathway

BMC Genomics, 2017
Background Lysine succinylation is a ubiquitous and important protein post-translational modification in various eukaryotic and prokaryotic cells. However, its functions in Dendrobium officinale, an important traditional Chinese orchid herb with high ...
Shangguo Feng, Kaili Jiao, Hong Guo, Mengyi Jiang, Juan Hao, Huizhong Wang, Chenjia Shen   +6 more
doaj   +2 more sources

The Mystery of Extramitochondrial Proteins Lysine Succinylation. [PDF]

Int J Mol Sci, 2021
Lysine succinylation is a post-translational modification which alters protein function in both physiological and pathological processes. Mindful that it requires succinyl-CoA, a metabolite formed within the mitochondrial matrix that cannot permeate the ...
Chinopoulos C.
europepmc   +2 more sources

SIRT5-Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate-Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis. [PDF]

Adv Sci (Weinh)
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Jiang Q, Dong C, Liu Y, Lou Y, Lin W, Li S, He Z.   +6 more
europepmc   +2 more sources